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  • 64603-91-4 Structure
  • Basic information

    1. Product Name: THIP HYDROCHLORIDE
    2. Synonyms: THIP HYDROCHLORIDE;4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3(2h)-onehydrate;4-c)pyridin-3(2h)-one,4,5,6,7-tetrahydro-isoxazolo(hydrate;gaboxadol;4,5,6,7-TETRAHYDROISOXAZOLO[5,4-C]PYRIDIN-3-OL;4,5,6,7-TETRAHYDROISOXAZOLO[5,4-C]PYRIDIN-3-OL HYDROCHLORIDE;gaboxadol hydrochloride;4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3(2H)-one
    3. CAS NO:64603-91-4
    4. Molecular Formula: C6H8N2O2
    5. Molecular Weight: 176.6
    6. EINECS: 264-963-0
    7. Product Categories: GABA/Glycine receptor
    8. Mol File: 64603-91-4.mol
    9. Article Data: 3
  • Chemical Properties

    1. Melting Point: 242-244° (dec)
    2. Boiling Point: 340.5 °C at 760 mmHg
    3. Flash Point: 159.7 °C
    4. Appearance: white/solid
    5. Density: 1.36 g/cm3
    6. Vapor Pressure: 0.00113mmHg at 25°C
    7. Refractive Index: N/A
    8. Storage Temp.: Store at RT
    9. Solubility: ethanol: 0.91 mg/mL
    10. PKA: pKa (water, 25°): 4.44 ±0.03; 8.48 ±0.04
    11. Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
    12. CAS DataBase Reference: THIP HYDROCHLORIDE(CAS DataBase Reference)
    13. NIST Chemistry Reference: THIP HYDROCHLORIDE(64603-91-4)
    14. EPA Substance Registry System: THIP HYDROCHLORIDE(64603-91-4)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: 22-24/25
    4. WGK Germany: 3
    5. RTECS: NY3396800
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 64603-91-4(Hazardous Substances Data)

64603-91-4 Usage

Description

THIP HYDROCHLORIDE, also known as Gaboxadol HCl, is a GABA-A receptor agonist with the chemical formula (64603-91-4). It is primarily recognized for its hypnotic properties and is used as a therapeutic agent in the treatment of various conditions.

Uses

Used in Pharmaceutical Industry:
THIP HYDROCHLORIDE is used as a GABAa agonist for its hypnotic properties, helping in the treatment of sleep disorders and other related conditions. Its agonistic action on GABA-A receptors promotes relaxation and sedation, making it a valuable compound in the development of medications for insomnia and other sleep-related issues.
Used in Neurological Research:
In addition to its pharmaceutical applications, THIP HYDROCHLORIDE is also used as a GABAc antagonist in neurological research. This dual functionality allows scientists to study the effects of GABA-A and GABA-c receptors separately, leading to a better understanding of their roles in the central nervous system and the development of targeted therapies for neurological disorders.

Biological Activity

Systemically active GABA A receptor agonist and GABA C receptor antagonist. Displays antinociceptive, anticonvulsant and sedative effects. Hypnotic agent that enhances delta activity within non-REM sleep in rats.

References

1) Meera et al. (2011), Molecular basis for the high THIP/gaboxadol sensitivity of extrasynaptic GABA(A) receptors; J. Neurophysiol., 106 2057

Check Digit Verification of cas no

The CAS Registry Mumber 64603-91-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,4,6,0 and 3 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 64603-91:
(7*6)+(6*4)+(5*6)+(4*0)+(3*3)+(2*9)+(1*1)=124
124 % 10 = 4
So 64603-91-4 is a valid CAS Registry Number.
InChI:InChI=1/C6H8N2O2.ClH/c9-6-4-1-2-7-3-5(4)10-8-6;/h7H,1-3H2,(H,8,9);1H

64603-91-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name THIP hydrochloride,4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-olhydrochloride

1.2 Other means of identification

Product number -
Other names Lu 02-030

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:64603-91-4 SDS

64603-91-4Relevant articles and documents

GABOXADOL FORMS, COMPOSITIONS THEREOF, AND RELATED METHODS

-

Page/Page column 27, (2008/06/13)

The invention provides novel gaboxadol forms. These forms include salts, hydrates, solvates, and polymorphs of gaboxadol. The invention also provides novel compositions comprising these novel soluble forms and a suitable carrier. The invention also provides related methods of treatment. Compositions and methods of the invention of the invention have a number of uses, including the treatment or prevention of sleep disorders.

Heterocyclic compounds

-

, (2008/06/13)

The compound Ia STR1 has been shown to possess GABA-related activity. The invention relates to Ia and derivatives thereof, covered by the formula STR2 in which R" is hydrogen, acetyl or a group of the general formula STR3 in which R5 is C1-8 alkyl; phenyl; phenyl substituted in the 4-position with halogen, lower alkoxy, or lower alkyl; or phenylalkyl in which the phenyl group may be substituted in the 4-position with halogen, lower alkoxy, or lower alkyl; and salts thereof. Novel intermediates for preparing I are STR4 in which Alk is a lower alkyl group and Z is hydrogen or an amino-protecting group; STR5 wherein Z is hydrogen or an amino-protecting group, T is a group convertible, by hydrolysis, into an oxy group, and Q is a leaving group which, on reaction with hydroxylamine, forms a hydroxamic acid group; STR6 wherein Z and T are as defined above; STR7 wherein Z is as defined above, and W is hydrogen or a group removable to yield the free hydroxy group, with the proviso that at least one of Z and W is different from hydrogen.

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