6456-78-6

Basic information

• Product Name: 6-chloroquinoline-8-carboxylic acid
• Synonyms: 6-chloroquinoline-8-carboxylic acid;6-Chloro-8-quinolinecarboxylic Acid;6-chloroquiolie-8-carboxylic acid
• CAS NO: 6456-78-6
• Molecular Formula: C₁₀H₆ClNO₂
• Molecular Weight: 207.615
• Product Categories: Amines;Aromatics;Heterocycles
• Mol File: 6456-78-6.mol

Chemical Properties

• Melting Point: 220-222°C
• Boiling Point: 410.3 °C at 760 mmHg
• Flash Point: 202 °C
• Appearance: /
• Density: 1.469 g/cm³
• Vapor Pressure: 1.81E-07mmHg at 25°C
• Refractive Index: 1.69
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility: Acetonitrile (Slightly), DMSO (Slightly)
• PKA: -2.78±0.10(Predicted)
• CAS DataBase Reference: 6-chloroquinoline-8-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloroquinoline-8-carboxylic acid(6456-78-6)
• EPA Substance Registry System: 6-chloroquinoline-8-carboxylic acid(6456-78-6)

Safety Data

• Hazardous Substances Data: 6456-78-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6-Chloroquinoline-8-carboxylic acid is used as an antimicrobial agent for its ability to inhibit the growth of various microorganisms, including bacteria and fungi. Its antimicrobial properties can be utilized in the development of new drugs to combat resistant strains and treat infections.
Used in Research and Development:
6-Chloroquinoline-8-carboxylic acid is used as a genotoxic agent in research settings to study the effects of genotoxic substances on cells and DNA. This can help in understanding the mechanisms of genotoxicity and developing strategies to mitigate the harmful effects of genotoxic agents.
Used in Chemical Synthesis:
6-Chloroquinoline-8-carboxylic acid can be used as a building block or intermediate in the synthesis of various chemical compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals. Its unique structure and functional groups make it a versatile component in organic synthesis.

InChI:InChI=1/C10H6ClNO2/c11-7-4-6-2-1-3-12-9(6)8(5-7)10(13)14/h1-5H,(H,13,14)

Upstream product

• 56-81-5 glycerol 
• 635-21-2 5-chloroanthranilic acid 

Downstream Products

• 64353-24-8 6-Chloro-N-(2-<4-methylphenyl>-ethyl)-chromane-8-carboxylic acid amide 

Relevant articles and documents

PLANT GROWTH REGULATOR

PROBLEM TO BE SOLVED: To provide a plant growth regulator. SOLUTION: The plant growth regulator comprises a compound represented by general formula 1, or a salt or ester thereof. [In the formula, (A1-A2-A3-A4) is (N=CH-CH=CH) or (NH-CH2-CH2-CH2); R1 and R2 are each independently H, an alkyl group or a halogen atom; and R3 is a hydroxyl group or an alkoxy group.] SELECTED DRAWING: None COPYRIGHT: (C)2018,JPO&INPIT

COMPOUNDS SUITABLE AS MODULATORS OF HDL

Disclosed herein in the embodiments of the present invention are the compounds suitable as modulators of HDL having general formula (1), novel intermediates involved in their synthesis, their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present invention also relates to a process of preparing compounds of general formula (1), their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.

COMPOUNDS SUITABLE AS MODULATORS OF HDL

Disclosed herein in the embodiments of the present invention are the compounds suitable as modulators of HDL having general formula (1), novel intermediates involved in their synthesis, their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present invention also relates to a process of preparing compounds of general formula (1), their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.

Hypoglycemic quinoline 8 carboxamidoalkyl benzenesulfonamide derivatives

The paper reports on acylaminoalkylbenzenesulfonyl ureas, sulfonylsemicarbazides and sulfonylaminopyrimidines, which carry as acylrest the rest of the quinoline 8 carboxylic acid, possibly substituted. Pharmacological tests reveal that the compounds have a strong blood sugar lowering effects.