64465-53-8

Basic information

• Product Name: 4-Fluoro-3-methoxyaniline
• Synonyms: BUTTPARK 14\01-65;4-FLUORO-3-METHOXYANILINE;3-METHOXY-4-FLUOROANILINE;4-Fluoro-3-Methoxybenzenamin;4-FLUORO-3-METHOXYBENZENAMINE;4-Fluoro-3-methoxyphenylamine;2-fluoro-5-aminoanisole(4-fluoro-3-methoxyaniline);5-Amino-2-fluoroanisole, 4-Fluoro-m-anisidine
• CAS NO: 64465-53-8
• Molecular Formula: C₇H₈FNO
• Molecular Weight: 141.14
• Product Categories: Amines;blocks;FluoroCompounds;Multisubstituted Benzene;Amines and Anilines;Halides;Anilines, Aromatic Amines and Nitro Compounds
• Mol File: 64465-53-8.mol

Chemical Properties

• Melting Point: 66-68
• Boiling Point: 252.5 °C at 760 mmHg
• Flash Point: 106.5 °C
• Appearance: /
• Density: 1.176 g/cm³
• Storage Temp.: 2-8°C(protect from light)
• PKA: 4.23±0.10(Predicted)
• CAS DataBase Reference: 4-Fluoro-3-methoxyaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluoro-3-methoxyaniline(64465-53-8)
• EPA Substance Registry System: 4-Fluoro-3-methoxyaniline(64465-53-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 20/21/22-36/37/38-52-41-37/38-22
• Safety Statements: 26-36/37/39-39
• HazardClass: IRRITANT
• Hazardous Substances Data: 64465-53-8(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 46, p. 2520, 1981 DOI: 10.1021/jo00325a017

InChI:InChI=1/C8H10FNO/c1-11-8-4-6(5-10)2-3-7(8)9/h2-4H,5,10H2,1H3

Upstream product

• 454-16-0 1-fluoro-2-methoxy-4-nitrobenzene 
• 3863-11-4 3,4-difluoroaniline 
• 536-90-3 m-Anisidine 
• 3866-16-8 3-methoxyphenyl azide 

Downstream Products

• 1188906-71-9 1-(5-tert-butylisoxazol-3-yl)-3-(3-(6_,7-dimethoxyquinazolin-4-yloxy)-4-fluorophenyl)urea 
• 1188906-70-8 1-(5-tert-butylisoxazol-3-yl)-3-(4-fluoro-3-hydroxyphenyl)urea 
• 960121-74-8 1,1-dimethylethyl 4-((4-fluoro-3-(methyloxy)phenyl)amino)-1-piperidinecarboxylate 
• 960121-75-9 N-(4-fluoro-3-(methyloxy)phenyl)-4-piperidinamine 
• 425378-85-4 2-(4-fluoro-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 117902-15-5 4-hydroxy-2-methoxy-fluorobenzene 

Relevant articles and documents

3,5-DISUBSTITUTED PYRAZOLES USEFUL AS CHECKPOINT KINASE 1 (CHK1) INHIBITORS, AND THEIR PREPARATIONS AND APPLICATIONS

Potent inhibitors of Chk1 have the structure formula (I) below. Pharmaceutical compositions comprising the Chk1 inhibitors, uses thereof and their preparation process.

1-(2-ALKYL-2,3-DIHYDRO-BENZOFURAN-4-YL)-PYRROLIDIN-3-YLAMINE ACYL COMPOUNDS

This invention provides new 1-(2-alkyl-2,3-dihydro-benzofuran-4-yl)-pyrrolidin-3- ylamine acyl compounds, their use for the treatment or prevention of melatoninergic disorders and its compositions.

Pyridonecarboxylic acid derivatives or salts thereof and drugs containing the same as the active ingredient

PCT No. PCT/JP97/04326 Sec. 371 Date May 28, 1999 Sec. 102(e) Date May 28, 1999 PCT Filed Nov. 27, 1997 PCT Pub. No. WO98/23592 PCT Pub. Date Jun. 4, 1998The invention relates to pyridonecarboxylic acid derivatives represented by the general formula (1): wherein R1 is -OH, a carboxy-protecting group or (alkyl)amino group, R2 is H, or -NO2, (protected) amino, (protected) hydroxyl, lower alkyl or lower alkoxyl group, R3 is a halogen atom, H, or -NO2, lower alkyl, lower alkoxyl or amino group, R4 is an azido, (substituted) hydrazino, (substituted) amino, lower alkoxyl or hydroxyl group, R5, R6 and R7 are independently H, -NO2, halogen atom or lower alkyl group, R8 is a -NO2, (substituted) amino, -OH or lower alkoxyl group, A is N or C-R12, in which R12 is H, halogen atom, or (substituted) lower alkyl, lower alkenyl, lower alkynyl, lower alkoxyl, lower alkylthio or nitro group, and B is N or C-R13, in which R13 is H or halogen atom, or salts thereof, and medicine comprising such a compound as an active ingredient. The derivatives or the salts thereof exhibit excellent antibacterial action and peroral absorbability, scarcely cause side effects, and are easy of synthesis.

Preparation of fluorinated anilines

Fluorinated anilines, especially p-fluoroaniline and 2,4-difluoroaniline, are prepared by treating aromatic azides with anhydrous hydrogen fluoride. The aromatic azides, in turn, are prepared from the corresponding anilines by treatment with nitrous acid or salt thereof and an alkali metal azide in the presence of a mineral acid, and in an aqueous-nonaqueous, two-phase environment.

Phenyl benzoic acid compounds

The invention relates to substituted 5-(phenyl)benzoic acid esters and non-toxic pharmaceutically accepted salts thereof and processes for their preparation. The substituted 5-(phenyl)benozic acids are useful as anti-inflammatory compounds. Also included are method of treating inflammation claims by administering these particular compounds to patients.