63930-17-6

Basic information

• Product Name: BIS(3-FLUOROPHENYL)DISULFIDE
• Synonyms: 3,3'-DIFLUORO DIPHENYL DISULFIDE;BIS(3-FLUOROPHENYL)DISULFIDE;BIS(3-FLUOROPHENYL)DISULPHIDE;3,3-Difluorodiphenyl disulphide~3-Fluorophenyl disulphide;Bis(3-Fluorphenyl)Disulfide;3-Fluorophenyldisulfide;Bis(3-fluorophenyl)disulphide 97%;Bis(3-fluorophenyl)disulphide97%
• CAS NO: 63930-17-6
• Molecular Formula: C₁₂H₈F₂S₂
• Molecular Weight: 254.32
• Mol File: 63930-17-6.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 308℃
• Flash Point: >110°(230°F)
• Appearance: yellow or colorless liquid
• Density: 1.32
• Vapor Pressure: 0.00106mmHg at 25°C
• Refractive Index: 1.619
• Storage Temp.: 2-8°C
• Sensitive: Stench
• BRN: 2530329
• CAS DataBase Reference: BIS(3-FLUOROPHENYL)DISULFIDE(CAS DataBase Reference)
• NIST Chemistry Reference: BIS(3-FLUOROPHENYL)DISULFIDE(63930-17-6)
• EPA Substance Registry System: BIS(3-FLUOROPHENYL)DISULFIDE(63930-17-6)

Safety Data

• Statements: 22
• Safety Statements: 23-36/37
• PackingGroup: III
• Hazardous Substances Data: 63930-17-6(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
Bis(3-fluorophenyl)disulfide is used as a reagent in chemical synthesis for creating various organic compounds. Its unique structure with fluorine and sulfur atoms allows it to participate in a range of reactions, making it a valuable component in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Research Applications:
In the field of research, bis(3-fluorophenyl)disulfide is employed as a building block for the development of new molecules with potential applications in materials science, medicinal chemistry, and other areas. Its presence in organofluorides and organosulfides makes it an interesting subject for studying the effects of fluorination and sulfuration on molecular properties and reactivity.
Used in Pharmaceutical Industry:
Bis(3-fluorophenyl)disulfide is used as a key intermediate in the synthesis of certain pharmaceutical compounds. Its incorporation into drug molecules can influence their pharmacokinetic and pharmacodynamic properties, such as solubility, stability, and bioavailability, which are crucial for their therapeutic efficacy.
Used in Agrochemical Industry:
In the agrochemical sector, bis(3-fluorophenyl)disulfide is utilized as a precursor in the production of pesticides and other crop protection agents. The introduction of fluorine and sulfur atoms into the molecular structure can enhance the activity and selectivity of these compounds, making them more effective in controlling pests and diseases in agriculture.

InChI:InChI=1/C12H8F2S2/c13-9-3-1-5-11(7-9)15-16-12-6-2-4-10(14)8-12/h1-8H

Upstream product

• 2557-77-9 3-fluorothiophenol 
• 1996-38-9 3-fluorobenzenediazonium tetrafluoroborate 

Downstream Products

• 1314532-84-7 tert-butyl (3aS,4R,6S,6aR)-6-(2-(3-fluorophenylthio)propan-2-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-ylcarbamate 
• 1314532-79-0 S-3-fluorophenyl 4-methylbenzenesulfonothioate 
• 1393673-41-0 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-(3-fluorophenyl)thio-1H-pyrazole-3-carbonitrile 
• 1631146-74-1 2-((3-fluorophenyl)thio)-2-(imidazolidin-2-ylidene)-1-phenylethan-1-one 
• 1631146-90-1 2-((4-fluorophenyl)thio)-1-phenyl-2-(tetrahydropyrimidin-2(1H)-ylidene)ethanone 
• 1631147-11-9 2-(1,3-diazepan-2-ylidene)-2-((4-fluorophenyl)thio)-1-phenylethan-1-one 
• 75220-74-5 m-fluorobenzenesulfenyl chloride 

Relevant articles and documents

Preparation method of symmetric disulfide bond-containing compound

The method comprises the following steps: adding a raw material and an oxidant to a reaction bottle containing a solvent; reacting 23W - 85W under the irradiation of 12 - 24h energy-saving lamps; and purifying the reaction product to obtain symmetrical disulfide bond-containing compounds. The raw material is mercaptan or thiophenol. The oxidizing agent is trichlorobromomethane, and the solvent is tetrahydrofuran. The method has the advantages of simple operation, high yield (70 - 90%), wide applicability, cheap and easily available raw materials, and provides a better way for the synthesis and production of symmetrical disulfide bond-containing compounds.

Forging C?S(Se) Bonds by Nickel-catalyzed Decarbonylation of Carboxylic Acid and Cleavage of Aryl Dichalcogenides

A nickel-catalyzed decarbonylation of carboxylic acids cross-coupling protocol has been developed for the straightforward C?S(Se) bond formation. This reaction is promoted by a commercially-available, user-friendly, inexpensive, air and moisture-stable nickel precatalyst. Various carboxylic acids and a wide range of aryl dichalcogenide substrates were tolerated in this process which afforded products in good to excellent yields. In addition, the present reaction can be conducted on gram scale in good yield.

Diaryl disulfides and thiosulfonates as combretastatin A-4 analogues: Synthesis, cytotoxicity and antitubulin activity

Diaryl disulfides and diaryl thiosulfonates were synthesized with the two phenyl rings of all compounds bearing identical halide substituents. Because of structural similarity to the potent antimitotic natural product combretastatin A-4 (CA-4), the compounds were examined for inhibition of tubulin polymerization, and the thiosulfonates were more active than the disulfides. The nine thiosulfonates had IC50 values ranging from 1.2 to 9.1 μM, as compared with 1.3 μM obtained with CA-4. The compounds thus ranged from equipotent with CA-4 to 7-fold less active. The nine disulfides had IC50 values ranging from 1.2 to 5.1 μM, as compared with 0.54 μM obtained with CA-4. The compounds thus ranged from less than half as active as CA-4 to over 9-fold less active. The most active members of each group, 2 g and 3c, in the assembly assay were modeled into the colchicine site. Compound 3c had significant hydrophobic interactions with β-tubulin residues CYS 241 and ALA 250, and its thiosulfonate bridge made a hydrogen bond with β-tubulin residue ASN 258. Compound 2 g had hydrophobic interactions with β-tubulin residues ALA 250, CYS 241 and ALA 254, but there was no significant interaction of the disulfide bridge with tubulin.

Synthesis and nano-Pd catalyzed chemoselective oxidation of symmetrical and unsymmetrical sulfides

A highly chemoselective, efficient and nano-Pd catalyzed protocol for the rapid construction of sulfoxides and sulfones via the oxidation of symmetrical and unsymmetrical sulfides using H2O2 as an oxidant has been developed, respectively. The ready availability of starting materials, easy recovery and reutilization of the catalyst, wide substrate scope, and high yields make this protocol an attractive alternative. The process also involves the metal-free and microwave-promoted synthesis of symmetrical diarylsulfides, and FeCl3-mediated preparation of symmetrical diaryldisulfides through the reaction of arenediazonium tetrafluoroborates with Na2S·9H2O as a sulfur source. In addition, unsymmetrical sulfides were generated via the K2CO3-mediated reaction of arenediazonium tetrafluoroborates with symmetrical disulfides.

An Organodiselenide with Dual Mimic Function of Sulfhydryl Oxidases and Glutathione Peroxidases: Aerial Oxidation of Organothiols to Organodisulfides

A novel organodiselenide, which mimics sulfhydryl oxidases and glutathione peroxidase (GPx) enzymes for oxidation of thiols by oxygen and hydrogen peroxide, respectively, into disulfides has been presented. The developed catalyst oxidizes an array of organothiols into respective disulfides in practical yields by using aerial O2 to avoid any reagents/additives, base, and light source. The synthesized diselenide also catalyzes the reduction of hydrogen peroxide into water by following the GPx enzymatic catalytic cycle with a reduction rate of 49.65 ± 3.7 μM·min-1.

Regiocontrolled direct C4 and C2-methyl thiolation of indoles under rhodium-catalyzed mild conditions

A straightforward Rh(iii)-catalyzed general strategy was developed for the site-selective remote C4 (sp2) and C2 (sp3)-methyl thiolation of an indole core, keeping the oxime directing group at the C3 position. The transformation was accomplished under mild conditions with a wide scope and functional group tolerance. The directing group can easily be removed after operation. Methyl substitution at the C2 position of the indole core led to C2 (sp3)-methyl thiolation.

Preparation of difluoromethylthioethers through difluoromethylation of disulfides using TMS-CF2H

We report an operationally simple, metal-free approach for the late-stage introduction of the important lipophilic hydrogen-bond donor motif, SCF2H. This reaction converts diaryl- and dialkyl-disulfides into the corresponding aryl/alkyl-SCF2H through the nucleophilic transfer of a difluoromethyl group with good functional group tolerance. This method is notable for its use of commercially available TMSCF2H, and does not rely on the need for handling of sensitive metal complexes.

Synthesis of β-Hydroxysulfides from Thiophenols and Disulfides with tert-Butyl Hydroperoxide as the Oxidant and Reactant

In this Communication, we developed a new procedure for the synthesis of β-hydroxysulfides from thiophenols or diaryl disulfides with TBHP as the oxidant. In the presence of zinc iodide or potassium iodide, with TBHP as the oxidant and pre-reactant, thiophenols and diaryl disulfides reacted with the methyl group of tBuOH smoothly and selectivity to give the corresponding 2-methyl-1-(arylthio)propan-2-ols as the terminal products in moderate to good yields.

BIPHENYLOXYACETIC ACID DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASE

The invention relates to substituted phenoxyacetic acids as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.

Efficient, high yield oxidation of thiols and selenols to disulphides and diselenides

Thiols and selenols are smoothly oxidised in high yield to disulphides and diselenides by sodium perborate at room temperature.