638-95-9 Usage
Description
Alpha-Amyrin, also known as α-Amyrin, is a pentacyclic triterpenoid belonging to the ursane family. It is characterized by the presence of a double bond between positions 12 and 13, and a hydroxy group substitution at the 3beta position. This natural compound is derived from various plant sources and has garnered interest due to its potential applications in various industries.
Uses
Used in Pharmaceutical Industry:
Alpha-Amyrin is used as a precursor for the synthesis of various pharmaceutical compounds, such as steroids, hormones, and other bioactive molecules. Its unique chemical structure allows for the development of new drugs with potential therapeutic applications.
Used in Cosmetic Industry:
In the cosmetic industry, alpha-Amyrin is utilized as an ingredient in skincare and hair care products due to its emollient, moisturizing, and anti-inflammatory properties. It helps improve skin hydration, elasticity, and overall health, making it a valuable addition to cosmetic formulations.
Used in Agrochemical Industry:
Alpha-Amyrin is employed as a component in the development of agrochemicals, such as pesticides and herbicides. Its bioactive properties contribute to the effectiveness of these products in controlling pests and promoting crop growth.
Used in Food Industry:
In the food industry, alpha-Amyrin is used as a natural additive for flavor enhancement and preservation. Its unique chemical properties provide a distinct taste and aroma to various food products, making it a sought-after ingredient in the culinary world.
Used in Nanotechnology:
Alpha-Amyrin has potential applications in nanotechnology, particularly in the development of nanomaterials for drug delivery and targeted therapies. Its biocompatibility and unique structural features make it a promising candidate for the design of novel nanoscale systems.
Purification Methods
Purify it by acetylation to the acetate followed by hydrolysis and recrystallisation from aqueous MeOH or from EtOH. The acetate when crystallised from pet ether, n-heptane or CHC
Check Digit Verification of cas no
The CAS Registry Mumber 638-95-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,3 and 8 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 638-95:
(5*6)+(4*3)+(3*8)+(2*9)+(1*5)=89
89 % 10 = 9
So 638-95-9 is a valid CAS Registry Number.
638-95-9Relevant articles and documents
Laird et al.
, p. 4108 (1960)
Synthesis of novel triterpene and N-allylated/N-alkylated niacin hybrids as α-glucosidase inhibitors
Narender, Tadigoppula,Madhur, Gaurav,Jaiswal, Natasha,Agrawal, Manali,Maurya, Chandan K.,Rahuja, Neha,Srivastava, Arvind K.,Tamrakar, Akhilesh K.
, p. 162 - 169 (2013)
Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia. α-Glucosidase (EC 3.2.1.20) inhibitors interfere with enzymatic action to slow down the liberation of d-glucose from oligosaccharides and disaccharides, resulting in delayed glucose absorption and decreased postprandial plasma glucose levels. In continuation of our drug discovery program on antidiabetic agents, we synthesized novel N-allylated/N-alkylated niacin and α-amyrin (4-9) and lupeol (12-16) hybrids and tested for their α-glucosidase inhibiting activity. Compounds 4-9 showed better activity profile than the marketed α-glucosidase inhibitor i.e. acarbose. Compound 4 possess the highest inhibitory action with IC50 of 5 μM. Kinetic and CD studies revealed that 4 inhibited the α-glucosidase in a noncompetitive manner and caused conformational changes in secondary structure of the enzyme protein.
Kohen,F. et al.
, p. 2710 - 2714 (1964)
An improved scalable synthesis of α- and β-amyrin
Serbian, Immo,Csuk, René
, (2018/07/13)
The synthesis of α- and β-amyrin was accomplished starting from easily accessible starting materials, oleanolic, and ursolic acid. The procedures allow the preparation of β-amyrin in an exceptionally short scalable manner via selective iodation and reduction. For α-amyrin, a different synthetic approach had to be chosen providing access to α-amyrin in medium-to-large scale.
Practical Synthesis of α-Amyrin, β-Amyrin, and Lupeol: The Potential Natural Inhibitors of Human Oxidosqualene Cyclase
Chen, Dongyin,Xu, Fengguo,Zhang, Pu,Deng, Jie,Sun, Hongbin,Wen, Xiaoan,Liu, Jun
, (2017/10/20)
A practical synthesis of α-amyrin (1), β-amyrin (2), and lupeol (3) was accomplished in total yields of 32, 42, and 40% starting from easily available ursolic acid (4), oleanolic acid (5), and betulin (6), respectively. Remarkably, these three natural pentacyclic triterpenes exhibited potential inhibitory activity against human oxidosqualene cyclase.
