6375-47-9Relevant articles and documents
Hydrogenation of 3-nitro-4-methoxy-acetylaniline with H2 to 3-amino-4-methoxy-acetylaniline catalyzed by bimetallic copper/nickel nanoparticles
Yang, Chenchen,Xue, Wuping,Yin, Hengbo,Lu, Zhipeng,Wang, Aili,Shen, Lingqin,Jiang, Yunyan
, p. 3358 - 3366 (2017)
Monometallic Cu, monometallic Ni, and bimetallic CuxNiy nanoparticles were prepared by a wet chemical reduction method. A Cu-Ni alloy phase was formed in the bimetallic CuxNiy nanoparticles. The bimetallic CuxNiy nanoparticles exhibited higher catalytic activity for the hydrogenation of 3-nitro-4-methoxy-acetylaniline (NMA) to 3-amino-4-methoxy-acetylaniline (AMA) with H2 than the sole Ni nanoparticles, which was ascribed to the effect of the Cu-Ni alloy phase. When the reaction was catalyzed over the bimetallic Cu0.7Ni0.3 catalyst at 140 °C for 2 h, the AMA selectivity was 99.4% when the NMA conversion was 95.7%. The reaction activation energy for NMA hydrogenation was 19.74 kJ mol-1.
Synthesis process of 2-amidogen-4-acetamido anisole
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Paragraph 0044; 0044-0046; 0048-0049; 0051-0052; 0054, (2020/03/28)
The invention discloses a synthesis process of 2-amidogen-4-acetamido anisole. The synthesis process of the 2-amidogen-4-acetamido anisole comprises the steps of adopting p-methoxyaniline as a raw material, carrying out partial acylation reaction on the p-methoxyaniline and acetic anhydride, and preparing to obtain p-acetamido anisole; then carrying out nitration reaction, carrying out one-pot method'reaction to obtain 2-nitro-4-acetamido anisole, and under the action of a Pd/C catalyst, reducing the 2-nitro-4-acetamido anisole by adopting hydrazine monoformate as a hydrogen source to preparethe 2-amidogen-4-acetamido anisole. The synthesis process provided by the invention is low in energy consumption, low in cost, less in solid wastes and waste liquids, green and environmentally friendly, simple to operate, mild in reaction conditions, and high in industrial safety coefficient, the total yield of the target compound is 85 percent or above (on the basis of an initial reaction raw material), the HPLC (High Performance Liquid Chromatography) purity is 99.0 percent or above, the target compound is high in yield and good in quality, and the synthesis process is more suitable for industrial production.
A 2 - amino - 4 - acetyl amino methyl ether synthesis method (by machine translation)
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, (2018/05/01)
The invention discloses a 2 - amino - 4 - acetyl amino methyl ether synthesis method. The synthetic method comprises the following steps: (1) in the presence of a catalyst A, to nitroanisole with hydrogen by a catalytic hydrogenation reduction reaction to obtain the amino anisole; (2) P a the fuel to the acetylation reaction acetyl amino anisole; (3) to the acetaminophen a fuel for nitration reaction to obtain the 2 - nitro - 4 - acetamido anisole; (4) in the presence of a catalyst B, 2 - nitro - 4 - acetyl amino methyl ether with hydrogen by secondary catalytic hydrogenation reduction reaction. This invention adopts the first acylation, re-nitration, reduction method for synthesis of 2 - amino - 4 - acetyl amino methyl ether, avoids the traditional directional acylate raw material is easy to oxidation in the process, a plurality of side reaction, the product is hard to separate, the problem of low purity, the method of the invention the synthetic product purity can be up to 99.5% -99.8%. (by machine translation)