63744-21-8

Basic information

• Product Name: 3,5-Dibromo-imidazo[1,2-a]pyrazine
• Synonyms: 3,5-Dibromo-imidazo[1,2-a]pyrazine;3,5-DIBROMOIMIDAZOL[1,2-A]PYRAZINE
• CAS NO: 63744-21-8
• Molecular Formula: C₆H₃Br₂N₃
• Molecular Weight: 276.93
• Mol File: 63744-21-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 2.35g/cm³
• Refractive Index: 1.802
• CAS DataBase Reference: 3,5-Dibromo-imidazo[1,2-a]pyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Dibromo-imidazo[1,2-a]pyrazine(63744-21-8)
• EPA Substance Registry System: 3,5-Dibromo-imidazo[1,2-a]pyrazine(63744-21-8)

Safety Data

• Hazardous Substances Data: 63744-21-8(Hazardous Substances Data)

Usage

General Description

3,5-Dibromo-imidazo[1,2-a]pyrazine is a chemical compound with the molecular formula C5H2Br2N2. It is a heterocyclic compound containing both nitrogen and bromine atoms. 3,5-Dibromo-imidazo[1,2-a]pyrazine has potential applications in the field of organic chemistry and drug discovery due to its unique structure and properties. 3,5-Dibromo-imidazo[1,2-a]pyrazine has been investigated for its potential use as a building block in the synthesis of pharmaceutical compounds and as a precursor in the development of new materials. Its chemical properties make it suitable for a variety of synthetic applications, and it is being studied for its potential biological activities as well. Overall, 3,5-Dibromo-imidazo[1,2-a]pyrazine is a compound of interest in the scientific community for its potential in diverse chemical and pharmaceutical applications.

InChI:InChI=1/C6H3Br2N3/c7-4-1-9-3-6-10-2-5(8)11(4)6/h1-3H

Upstream product

• 274-79-3 imidazo[1,2-a]pyrazine 

Downstream Products

• 787590-51-6 (3-bromo-imidazo[1,2-a]pyrazin-8-yl)-(4-methoxy-phenyl)-amine 
• 117718-92-0 8-amino-3-bromoimidazo<1,2-a>pyrazine 
• 1011472-16-4 LG₂-91 
• 1011472-12-0 LG₂-77 
• 1011472-09-5 3-bromo-N-phenylimidazo[1,2-a]pyrazin-8-amine 
• 1011472-03-9 C₁₅H₁₅BrN₄O₃ 
• 1011472-00-6 C₁₈H₁₃BrN₄O 

Relevant articles and documents

Synthesis and Antibronchospastic Activity of 8-Alkoxy- and 8-(Alkylamino)imidazopyrazines

Theophylline still occupies a dominant place in asthma therapy.Unfortunatly its adverse central nervous system (CNS) stimulant effects can dramatically limit its use, and adjustments in the dosage are often needed.We have synthesized a new series of imidazopyrazine derivatives which are much more potent bronchodilators than theophylline in vivo and do not exhibit the CNS stimulatory profile.In vitro studies on isolated rat uterus and guinea pig trachea confirm the high potentialities of these derivatives. 6-Bromo-8-(methylamino)imidazopyrazine-3-carbonitrile (23) is identified as the most potent compound of the series.As i n the case of theophylline, phosphodiesterase inhibition appears unlikely to be the unique mechanism of the action of this series of heterocycles.

Synthesis of imidazo[1,2-a]pyrazine derivatives with uterine-relaxing, antibronchospastic, and cardiac-stimulating properties

A series of imidazo[1,2-a]pyrazine derivatives was synthesized by condensation of α-halogenocarbonyl compounds and aminopyrazines. Various compounds resulted from competitive reactions or reagent isomerization and demonstrated in vitro uterine-relaxing and in vivo antibronchospastic activities. On isolated atria, 5-bromoimidazo[1,2-a]pyrazine showed positive chronotropic and inotropic properties; the latter was associated with an increase in the cyclic AMP tissue concentration. Potentiation of the isoproterenol positive inotropic effect of 5-bromoimidazo[1,2-a]pyrazine and the lack of blockade of the 5-bromoimidazo[1,2-a]pyrazine positive inotropic effect by propranolol suggested phosphodiesterase-inhibiting properties.