63658-16-2Relevant articles and documents
Catalytic, contra-Thermodynamic Positional Alkene Isomerization
Occhialini, Gino,Palani, Vignesh,Wendlandt, Alison E.
supporting information, p. 145 - 152 (2022/01/19)
The positional isomerization of C═C double bonds is a powerful strategy for the interconversion of alkene regioisomers. However, existing methods provide access to thermodynamically more stable isomers from less stable starting materials. Here, we report
Preclinical Optimization of gp120 Entry Antagonists as anti-HIV-1 Agents with Improved Cytotoxicity and ADME Properties through Rational Design, Synthesis, and Antiviral Evaluation
Curreli, Francesca,Ahmed, Shahad,Benedict Victor, Sofia M.,Iusupov, Ildar R.,Belov, Dmitry S.,Markov, Pavel O.,Kurkin, Alexander V.,Altieri, Andrea,Debnath, Asim K.
, p. 1724 - 1749 (2020/03/10)
We previously reported a milestone in the optimization of NBD-11021, an HIV-1 gp120 antagonist, by developing a new and novel analogue, NBD-14189 (Ref1), which showed antiviral activity against HIV-1HXB2, with a half maximal inhibitory concentr
Npys-Mediated Elimination Reactions of Alcohols and Thiols: A Facile Route to Dehydroalanine and Dehydrobutyrine Building Blocks
Olsen, Frank N.,Tsakos, Michail,Poulsen, Thomas B.
supporting information, p. 2697 - 2701 (2015/11/27)
We report a new and rapid method for side-chain dehydration/dehydrothiolation of serine, threonine, and cysteine building blocks. The method relies on activation with 3-nitro-2-pyridinesulfenyl chloride (Npys-Cl) followed by treatment with base. It is pos