63516-03-0

Basic information

• Product Name: p-Aminobenzylbromide
• Synonyms: p-Aminobenzylbromide;4-(bromomethyl)-Benzenamine;Benzenamine,4-(bromomethyl)-
• CAS NO: 63516-03-0
• Molecular Formula: C₇H₈BrN
• Molecular Weight: 186.05
• Mol File: 63516-03-0.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 270.1±15.0 °C(Predicted)
• Appearance: /
• Density: 1.534±0.06 g/cm3(Predicted)
• PKA: 4.24±0.10(Predicted)
• CAS DataBase Reference: p-Aminobenzylbromide(CAS DataBase Reference)
• NIST Chemistry Reference: p-Aminobenzylbromide(63516-03-0)
• EPA Substance Registry System: p-Aminobenzylbromide(63516-03-0)

Safety Data

• Hazardous Substances Data: 63516-03-0(Hazardous Substances Data)

Usage

Description

p-Aminobenzylbromide, also known as 4-(aminomethyl)benzyl bromide, is a chemical compound with the molecular formula C7H8BrN. It is a colorless to pale yellow liquid with a strong, unpleasant odor. This versatile building block in organic chemistry is commonly used as an intermediate in the synthesis of various pharmaceuticals and organic compounds, including drugs and dyes.

Uses

Used in Pharmaceutical Industry:
p-Aminobenzylbromide is used as a synthetic intermediate for the production of various pharmaceuticals, contributing to the development of new drugs and improving existing ones.
Used in Organic Chemistry:
p-Aminobenzylbromide is used as a versatile building block in organic chemistry, facilitating the synthesis of a wide range of organic compounds.
Used in Dye Production:
p-Aminobenzylbromide is used as a key component in the production of dyes, enhancing the color properties and applications of various dyes in different industries.
Safety Precautions:
It is important to handle p-Aminobenzylbromide with care, as it is corrosive and may cause irritation to the skin, eyes, and respiratory tract upon contact. Proper safety precautions, such as wearing protective clothing and working in a well-ventilated area, should be followed when handling this chemical.

Upstream product

• 100-61-8 N-methylaniline 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 623-04-1 4-aminobenzenemethanol 
• 556-18-3 4-aminobenzaldehyde 
• 106-49-0 p-toluidine 

Downstream Products

• 79560-96-6 N-(4-amino-benzyl)-p-toluidine 
• 24007-66-7 N-(4-aminobenzyl)aniline 
• 79560-97-7 C₁₃H₁₃BrN₂ 
• 98818-45-2 5(S)-(Boc-amino)-4(S)-hydroxy-6-phenyl-2(R)-phenylmethylhexanoic acid 
• 98818-51-0 N-(1,1-dimethylethoxycarbonyl)-5(S)-amino-4(S)-(t-butyldimethylsilyloxy)-6-phenyl-2(R)-(phenylmethyl)hexanoic acid 
• 126409-24-3 {(1S)-benzyl-(4R)-[1-((1S)-carbamoyl-2-phenyl-ethylcarbamoyl)-(1S)-3-methyl-butyl-carbamoyl]-(2S)-hydroxy-5-phenyl-pentyl} carbamic acid tert-butyl ester 
• 126410-32-0 {(1S,2S,4R)-1-Benzyl-2-(tert-butyl-dimethyl-silanyloxy)-4-[(S)-1-((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-3-methyl-butylcarbamoyl]-5-phenyl-pentyl}-carbamic acid tert-butyl ester 
• 126456-36-8 L-685434 
• 147912-04-7 [(1S,2S,4R)-1-Benzyl-2-(tert-butyl-dimethyl-silanyloxy)-4-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-carbamic acid tert-butyl ester 
• 1158726-88-5 C₃₆H₆₂N₂O₃Si 
• 238764-65-3 C₁₁H₁₁N₃O 
• 1213234-82-2 3,4,5-tribromobenzyl azide 
• 1346427-28-8 C₁₀H₈Br₃N₅O 

Relevant articles and documents

Selective reduction of nitro group in aryl halides catalyzed by silver nanoparticles modified with β-CD

In this paper, we first report the selective reduction of nitro group in aryl halides catalyzed by silver nanoparticles modified with β-CD. Taking advantage of hydrophobic lumen and donor-acceptor behavior of β-CD, the halogenated alkyl groups on the aromatic ring can be enveloped in the inner cavity that thereby inhibits the reduction of the halogen. For validating the mechanism proposed by us, different silver nanoparticles were applied in parallel experiments. In our experiments, UV-vis spectra and NMR spectra were used to characterize the selectivity. This strategy represents an outstanding improvement on the synthesis of halogenated aromatic amines in comparison with the traditional route, and greatly expands the application of silver nanoparticles in catalytic field.

Ultra-low-loading palladium nanoparticles stabilized on nanocrystalline Polyaniline (Pd@PANI): A efficient, green, and recyclable catalyst for the reduction of nitroarenes

Ultra-low-loading Pd@PANI nanocomposites (0.048 w.t% Pd) were synthesized via a method that combined interfacial polymerization and in situ composite with camphor sulfonic acid ((+)-CSA) as a dopant. Transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectra, and X-ray photoelectron spectroscopy (XPS) were performed to characterize the structures. It can be used as an efficient catalyst for the reduction of nitroarenes in aqueous solution by using a smaller amount of NaBH4 (2.5 equiv.) at room temperature with high activity (TON?=?3.4?×?103), good stability (cycled eight times), as well as wide applicability (27 substrates). The catalyst also showed a marvelous activity in the gram-level reaction (yield?=?92%). UV–Visible spectrophotometry was used to investigate the reaction kinetics for the reduction of 4-nitrophenol to 4-aminophenol, and the results reconfirmed the excellent performance of the catalyst. The unique properties and superior performance of the prepared ultra-low-loading Pd@PANI nanocomposites lead it be an attractive alternative catalyst for conventional organic catalytic applications.

Synthesis and Biological Evaluation of 1,2,3-triazole tethered Pyrazoline and Chalcone Derivatives

A series of pyrazoline derivatives and corresponding chalcone intermediates with substituents same as combretastatin-A4(CA-4) conjugated with triazole nucleus has been synthesized and evaluated for their anticancer potential. Sulphorhodamine B(SRB) assay indicated compound 12c to be the most active compound from the series with GI50 value of 6.7 μm against the human liver carcinoma cell line HepG2. Interestingly, the intermediate 11c exhibited more promising cytotoxicity demonstrating GI50 value of 1.3 μm against the prostate cancer cell line DU145. Compounds 11c and 12c caused accumulation of cells in G2/M phase and inhibited tubulin polymerization. Furthermore, these compounds reduce the mitochondrial membrane potential and activate caspases 3 and 9, thereby indicating their ability to trigger apoptosis.