63472-21-9

Basic information

• Product Name: Propanoic acid, 3-([1,1'-biphenyl]-4-yloxy)-
• Synonyms: 3-biphenyl-4-yloxy-propionic acid;3-Biphenyl-4-yloxy-propionsaeure;p-Biphenyl-propionsaeure-aether
• CAS NO: 63472-21-9
• Molecular Formula: C15H14O3
• Molecular Weight: 242.274
• Mol File: 63472-21-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Propanoic acid, 3-([1,1'-biphenyl]-4-yloxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanoic acid, 3-([1,1'-biphenyl]-4-yloxy)-(63472-21-9)
• EPA Substance Registry System: Propanoic acid, 3-([1,1'-biphenyl]-4-yloxy)-(63472-21-9)

Safety Data

• Hazardous Substances Data: 63472-21-9(Hazardous Substances Data)

Upstream product

• 92-66-0 4-bromo-1,1'-biphenyl 
• 3284-80-8 3-(2,4-dichlorophenoxy)propionic acid 
• 173025-78-0 3-(4-phenylphenoxy)-1-propanol 
• 92-69-3 4-Phenylphenol 
• 63472-20-8 3-(biphenyl-4-yloxy)-propionitrile 
• 57-57-8 β-Propiolactone 

Downstream Products

• 73316-17-3 6-phenyl-2,3-dihydro-4H-1-benzopyran-4-one 
• 92-69-3 4-Phenylphenol 
• 13333-86-3 4-phenylphenoxyacetic acid 
• 42973-13-7 2-(biphenyl-4-yloxy)acetyl chloride 

Relevant articles and documents

2-AMINO-1,3,4-THIADIAZINE AND 2-AMINO-1,3,4-OXADIAZINE BASED ANTIFUNGAL AGENTS

The invention provides a compound which is a diazine of formula (I) or a tautomer thereof, or a pharmaceutically acceptable salt thereof, for use as an antifungal agent: (I) wherein X, N', C', A and E are as defined herein. The invention also provides a compound of Formula (I) as defined herein.

Discovery of potent nonpeptide inhibitors of stromelysin using SAR by NMR

With the use of an NMR-based method, potent (IC50 25 nM) nonpeptide inhibitors of the matrix metalloproteinase stromelysin (MMP-3) were discovered. The method, called SAR by NMR (for structure-activity relationships by nuclear magnetic resonance), involves the identification, optimization, and linking of compounds that bind to proximal sites on a protein. Using this technique, two ligands that bind weakly to stromelysin (acetohydroxamic acid, K(D) = 17 mM; 3-(cyanomethyl)-4'-hydroxybiphenyl, K(D) = 0.02 mM) were identified. On the basis of NMR-derived structural information, the two fragments were connected to produce a 15 nM inhibitor of this enzyme. This compound was rapidly discovered (less than 6 months) and required only a minimal amount of chemical synthesis. These studies indicate that the SAR by NMR method can be effectively applied to enzymes to yield potent lead inhibitors-an important part of the drug discovery process.

Substituted benzopyran and tetrahydronaphthalene compounds useful for safening herbicides in crops

There is provided a method for safening herbicides in crop plants by using substituted benzopyran or tetrahydronaphthalene compounds of formula I STR1 Further provided are compounds of formula II and compositions comprising a herbicide and an antidotally