6322-49-2

Basic information

• Product Name: 4-CHLORO-2-BUTANONE
• Synonyms: B-CHLOROETHYL METHYL KETONE;TIMTEC-BB SBB007824;4-chlorobutan-2-one;4-Chloro-2-butanone, Pract.;Einecs 228-680-6;2-Butanone, 4-chloro-;2-Chloroethylmethylketone;4-CHLORO-2-BUTANONE
• CAS NO: 6322-49-2
• Molecular Formula: C₄H₇ClO
• Molecular Weight: 106.55
• EINECS: 228-680-6
• Product Categories: Fine Chemical;API Intermediate
• Mol File: 6322-49-2.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 146℃
• Flash Point: 45℃
• Appearance: /
• Density: 1.033
• Vapor Pressure: 4.82mmHg at 25°C
• Refractive Index: 1.4299-1.4334
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: 4-CHLORO-2-BUTANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-2-BUTANONE(6322-49-2)
• EPA Substance Registry System: 4-CHLORO-2-BUTANONE(6322-49-2)

Safety Data

• Hazardous Substances Data: 6322-49-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C4H7ClO/c1-4(6)2-3-5/h2-3H2,1H3

Upstream product

• 2203-34-1 4-chloro-2-butanol 
• 7647-01-0 hydrogenchloride 
• 78-94-4 methyl vinyl ketone 
• 7664-93-9 sulfuric acid 
• 25790-55-0 4-chloro-1,2-butadiene 
• 7446-70-0 aluminium trichloride 
• 74-85-1 ethene 
• 75-36-5 acetyl chloride 
• 110-54-3 hexane 
• 7705-08-0 iron(III) chloride 
• 107-06-2 1,2-dichloro-ethane 
• 927-73-1 3-butenyl chloride 
• 50-00-0 formaldehyd 
• 67-64-1 acetone 

Downstream Products

• 61703-95-5 8-methoxy-4-methylquinoline 
• 57398-28-4 1-chloro-3,3-ethylenedioxybutane 
• 10150-87-5 1-acetoxybutan-3-one 
• 476471-88-2 6-ethoxy-4-methylquinoline 
• 78-94-4 methyl vinyl ketone 
• 1985-88-2 4-chloro-2-methyl-2-butanol 
• 88325-31-9 {PdCl₃(P(C₆H₅)3)}^(1-)*{(P(C₆H₅)3)(CH₂CH₂COCH₃)}⁽¹⁺⁾ = {PdCl₃(P(C₆H₅)3)}{(P(C₆H₅)3)(CH₂CH₂COCH₃)} 
• 88325-31-9 PdCl₃P(C₆H₅)3^(1-)*P(C₆H₅)3(CH₂CH₂COCH₃)⁽¹⁺⁾={PdCl₃P(C₆H₅)3}{P(C₆H₅)3(CH₂CH₂COCH₃)} 
• 10252-46-7 3-methyl-1-phenyl-4,5-dihydropyrazole 
• 491-35-0 C₆H₄NCH₂CHCCH₂ 
• 3299-38-5 4-(diethylamino)butan-2-one 
• 41037-29-0 6-chloro-4-methylquinoline 
• 5063-03-6 2-acetyl-5-norbornene 
• 2550-26-7 4-Phenyl-2-butanone 

Relevant articles and documents

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Synthesis method of 4-chloro-2-butanone

The invention provides a synthesis method of 4-chloro-2-butanone. The synthesis method comprises main steps as follows: (1) cooling an organic solution of butyl ketone to 0-30 DEG C; (2) adding hydrogen chloride, and then, conducting a thermal insulation reaction at room temperature for 1-5 h; (3) washing a product with a washing liquid to be neutral; and (4) performing reduced pressure distillation to obtain a finished product of 4-chloro-2-butanone. The synthesis method of 4-chloro-2-butanone directly conducts an anti-Markovnikov addition reaction with butyl ketone and hydrogen chloride gasto produce the product synthesis method of 4-chloro-2-butanone, and the process produces little sewage and is suitable for industrial production.

Photolysis of Tp′Rh(CNneopentyl)(PhNCNneopentyl) in the presence of ketones and esters: Kinetic and thermodynamic selectivity for activation of different aliphatic C-H bonds

The active fragment [Tp′Rh(CNneopentyl)], generated from the precursor Tp′Rh(CNneopentyl)(PhNCNneopentyl), underwent oxidative addition of substituted ketones and esters resulting in Tp′Rh(CNneopentyl)(R)(H) complexes (Tp′ = tris-(3,5-dimethylpyrazolyl)borate). These C-H activated complexes underwent reductive elimination at varying temperatures (24-70 °C) in C6D6 or C6D12. Using previously established kinetic techniques, the relative Rh-C bond strengths were calculated. Analysis of the relative Rh-C bond strengths vs. C-H bond strengths shows a linear correlation with slope RM-C/C-H = 1.22 (12). In general, α-substituents increase the relative Rh-C bond strengths compared to the C-H bond that is broken.

Regio- and stereoselective monoamination of diketones without protecting groups

Hitting the right target: Differentiation between two keto moieties was accomplished by a regio- and enantioselective bioamination employing ω-transaminases. Using 1,5-diketones as substrates gave access to the optically pure 2,6-disubstituted piperidine scaffold. The approach allowed the shortest synthesis of the alkaloid dihydropinidine, as well as its enantiomer, by choosing an appropriate ω-transaminase. Copyright