6321-23-9

Basic information

• Product Name: 4-Methylcyclohexyl amine
• Synonyms: 4-methylcyclohexylamine, mixed isomers;4-METHYLCYCLOHEXYLAMINE, 97%, MIXTURE OF CIS AND TRANS;4-MethylmorpholineN-OxideIn50%Solution;1-Amino-4-methylcyclohexane;4-Methylcyclohexylamine, mixture of cis and trans, 97%;4-METHYLCYCLOHEXAMINE;4-methyl-cyclohexanamine;p-Methylcyclohexylamine
• CAS NO: 6321-23-9
• Molecular Formula: C₇H₁₅N
• Molecular Weight: 113.2
• EINECS: 228-673-8
• Product Categories: Amines;C7;Nitrogen Compounds;Pyridines ,Halogenated Heterocycles
• Mol File: 6321-23-9.mol
• Article Data: 16

Chemical Properties

• Melting Point: -8.5°C (estimate)
• Boiling Point: 151-154 °C(lit.)
• Flash Point: 80 °F
• Appearance: clear colourless liquid
• Density: 0.855 g/mL at 25 °C(lit.)
• Vapor Pressure: 4.049mmHg at 25°C
• Refractive Index: n20/D 1.4531(lit.)
• Storage Temp.: Flammables area
• PKA: 10.58±0.70(Predicted)
• CAS DataBase Reference: 4-Methylcyclohexyl amine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methylcyclohexyl amine(6321-23-9)
• EPA Substance Registry System: 4-Methylcyclohexyl amine(6321-23-9)

Safety Data

• Hazard Codes: C,Xi
• Statements: 10-34
• Safety Statements: 16-26-27-36/37/39-45
• RIDADR: UN 2734 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 6321-23-9(Hazardous Substances Data)

Usage

Chemical Properties

CLEAR COLOURLESS LIQUID

Uses

4-Methylcyclohexylamine is an inhibitor of spermidine synthase

General Description

Trans-4-methylcyclohexylamine is a spermidine synthase inhibitor.

InChI:InChI=1/C7H15N/c1-6-2-4-7(8)5-3-6/h6-7H,2-5,8H2,1H3/t6-,7-

Upstream product

• 7647-01-0 hydrogenchloride 
• 106-49-0 p-toluidine 
• 64-19-7 acetic acid 
• 589-91-3 p-methylcyclohexanol 
• 7664-41-7 ammonia 
• 616-38-6 carbonic acid dimethyl ester 
• 96-49-1 [1,3]-dioxolan-2-one 
• 99-99-0 1-methyl-4-nitrobenzene 
• 101-77-9 4,4'-diamino diphenyl methane 
• 589-92-4 1-methylcyclohexan-4-one 
• 39477-43-5 4-metylcyclohexanone O-methyloxime 
• 92377-01-0 1,2-bis(4-methylcyclohexylidene)hydrazine 
• 86467-47-2 4-methyl-cyclohexanone-hydrazone 
• 4994-13-2 4-methylcyclohexanone oxime 

Downstream Products

• 2523-88-8 trans-N,4-dimethylcyclohexylamine 
• 13908-15-1 1-(4-methylcyclohexyl)-3-(2-chloroethyl)urea 
• 42184-40-7 (4-Methyl-cyclohexyl)-dithiophosphoramidic acid diethyl ester 
• 33021-77-1 N-<2-Fluor-aethyl>-N'-<4-methyl-cyclohexyl>-harnstoff 
• 2539-44-8 C₂₂H₂₇N₃O₄S 
• 17485-50-6 C₁₅H₂₁N₃O₅S 
• 20406-43-3 N-(p-Tolylsulfonyl)-N'-(4-methylcyclohexyl)harnstoff 
• 134274-04-7 6,7-methylenedioxy-9-(N-4-methylcyclohexyliminio)-9H-pyrrolo<1.2-a>indole hydrobromide 
• 140119-49-9 N-(4-methylcyclohexyl)-9H-pyrrolo<1,2-a>indol-9-imine 
• 193805-17-3 C₁₀H₁₇N₃S 

Relevant articles and documents

One-pot synthesis of cyclohexylamine and: N -aryl pyrroles via hydrogenation of nitroarenes over the Pd0.5Ru0.5-PVP catalyst

The direct synthesis of cyclohexylamine via the hydrogenation of nitrobenzene over monometallic (Pd, Ru or Rh) and bimetallic (PdxRu1-x) catalysts was studied. The Pd0.5Ru0.5-PVP catalyst was the most effective catalyst for this reaction. The catalyst can be reused and applied for the synthesis of N-aryl pyrroles and quinoxalines from nitrobenzenes.

Ruthenium-Na2CO3-catalyzed one-pot synthesis of ring-hydrogenated carbamates from aromatic amines and organic carbonates under H2

A facile and efficient one-pot procedure for the synthesis of ring hydrogenated carbamates from aromatic amine and alkylene carbonate under H2 gas pressure has been developed using a heterogeneous catalyst system comprising ruthenium and alkali metal carbonates. The effects of temperature, H2 pressure, catalyst (types of loaded metal and their supports), molar ratio of substrate/catalyst, and solvent were also investigated. Among the alkali metal carbonates, the sodium carbonate was found as best promoter for nucleophilic attack and ring-opening (NARO) reaction and thus increased the yield of ring hydrogenated carbamate up to 88% when using Ru/C as ring hydrogenation (RH) catalyst. This catalyst system could be reused at least five times without signi?cant loss of activity, which makes this process cost-effective and eco-friendly.

2-aminopyridine derivatives and combinatorial libraries thereof

The present invention relates to novel 2-aminopyridine derivative compounds of the following formula: wherein R1to R5have the meanings provided herein. The invention further relates to combinatorial libraries containing two or more such compounds, as well as methods of preparing 2-aminopyridine derivative compounds.