63024-77-1

Basic information

• Product Name: 3-(Chloromethyl)benzoyl chloride
• Synonyms: 3-(CHLOROMETHYL)BENZOYL CHLORIDE;M-(CHLOROMETHYL)BENZOYL CHLORIDE;3-Chloro-4-MethylBenzoylChloride;Benzoyl chloride, 3-(chloromethyl)- (9CI);3-(CHLOROMETHYL)BENZOYL CHLORIDE 98%;m-Toluoyl chloride, a-chloro-;3-(Chloromethyl)benzoic acid chloride;3-(Chloromethyl)benzoyl chloride,98%
• CAS NO: 63024-77-1
• Molecular Formula: C₈H₆Cl₂O
• Molecular Weight: 189.04
• EINECS: 263-799-7
• Product Categories: ACIDHALIDE;HALOMETYL;Acid Halides;Carbonyl Compounds;Organic Building Blocks;Acid Halides;Building Blocks;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
• Mol File: 63024-77-1.mol
• Article Data: 14

Chemical Properties

• Melting Point: 4 °C
• Boiling Point: 149-150 °C20 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: Clear colorless to light yellow/Liquid
• Density: 1.33 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00785mmHg at 25°C
• Refractive Index: n20/D 1.5748(lit.)
• Sensitive: Moisture Sensitive
• BRN: 2436228
• CAS DataBase Reference: 3-(Chloromethyl)benzoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(Chloromethyl)benzoyl chloride(63024-77-1)
• EPA Substance Registry System: 3-(Chloromethyl)benzoyl chloride(63024-77-1)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45-25
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 63024-77-1(Hazardous Substances Data)

Usage

Chemical Properties

CLEAR COLOURLESS LIQUID

Uses

Different sources of media describe the Uses of 63024-77-1 differently. You can refer to the following data:
1. 3-(Chloromethyl)benzoyl chloride is used to prepare water-soluble, solution-stable, bioactive prodrugs.1
2. 3-(Chloromethyl)benzoyl chloride has been used in the preparation of:new amphiphilic star polymers possessing a hyperbranched core and hydrophilic graft armswater-soluble, solution-stable, bioactive prodrugs

InChI:InChI=1/C8H6Cl2O/c9-5-6-2-1-3-7(4-6)8(10)11/h1-4H,5H2

Upstream product

• 1711-06-4 3-Methylbenzoyl chloride 
• 50-00-0 formaldehyd 
• 98-07-7 Benzotrichlorid 
• 6515-58-8 3-bromomethylbenzoic acid 
• 28286-79-5 3-(Hydroxymethyl)benzoic acid 
• 99-04-7 m-Toluic acid 
• 31719-77-4 3-chloromethylbenzoic acid 

Downstream Products

• 88482-77-3 5-(m-Chloromethylbenzoyl)-10,11-dihydro-5H-dibenzazepine 
• 855249-06-8 (3-chloromethylphenyl)pyrrolidin-1-ylmethanone 
• 1026920-24-0 Azepan-1-yl-(3-chloromethyl-phenyl)-methanone 
• 251295-68-8 (3-chloromethyl)benzoic acid chloromethyl ester 
• 138591-67-0 3-[(Methyl-prop-2-ynyl-amino)-methyl]-benzoic acid methyl ester 
• 138591-68-1 3-[(Methyl-prop-2-ynyl-amino)-methyl]-benzoic acid ethyl ester 
• 138591-69-2 3-[(Methyl-prop-2-ynyl-amino)-methyl]-benzoic acid benzyl ester 
• 847225-08-5 3-(chloromethyl)-N-(3-methoxyphenyl)benzamide 
• 864775-42-8 (S)-(3-(5-chloro-2-methoxyphenyl)-3-fluoro-2-oxo-6-(trifluoromethyl)indolin-1-yl)methyl 3-(chloromethyl)benzoate 
• 865295-25-6 (2S,4R)-4-[(3-Chloromethyl-benzoylamino)-methyl]-2-(thiazolidine-3-carbonyl)-pyrrolidine-1-carboxylic Acid Tert-butyl Ester 

Relevant articles and documents

GLUCOPYRANOSE DERIVATIVES USEFUL AS SGLT2 INHIBITORS

The present invention is directed to glucopyranose derivatives of formula (I), pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by SGLT2 activity. More particularly, the compounds of the present invention are useful in the treatment of for example, Type II diabetes mellitus, Syndrome X, and complications and symptoms associated with said disorders.

Modular Tuning of Electrophilic Reactivity of Iridium Nitrenoids for the Intermolecular Selective α-Amidation of β-Keto Esters

We report herein an Ir-catalyzed intermolecular amino group transfer to β-keto esters (amides) to access α-aminocarbonyl products with excellent chemoselectivity. The key strategy was to engineer electrophilicity of the putative Ir-nitrenoids by tuning electronic property of the κ2-N,O chelating ligands, thus facilitating nucleophilic addition of enol π-bonds of 1,3-dicarbonyl substrates.

MATRIX METALLOPROTEINASE (MMP) INHIBITORS AND METHODS OF USE THEREOF

Hydantoin based compounds useful as inhibitors of matrix metalloproteinases (MMPs), particularly macrophage elastase (MMP-12) are described. Also described are related compositions and methods of using the compounds to inhibit MMP-12 and treat diseases mediated by MMP-12, such as asthma, chronic obstructive pulmonary disease (COPD), emphysema, acute lung injury, idiopathic pulmonary fibrosis (IPF), sarcoidosis, systemic sclerosis, liver fibrosis, nonalcoholic steatohepatitis (NASH), arthritis, cancer, heart disease, inflammatory bowel disease (IBD), acute kidney injury (AKI), chronic kidney disease (CKD), Alport syndrome, and nephritis.