6299-66-7

Basic information

• Product Name: Hexanoic acid, 4-ethyl-
• Synonyms: Hexanoic acid, 4-ethyl-;NSC 44869
• CAS NO: 6299-66-7
• Molecular Formula: C₈H₁₆O₂
• Molecular Weight: 144.21144
• Mol File: 6299-66-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 228.91°C (estimate)
• Flash Point: 116.6 °C
• Appearance: /
• Density: 0.9173 (rough estimate)
• Vapor Pressure: 0.0182mmHg at 25°C
• Refractive Index: 1.4128 (estimate)
• CAS DataBase Reference: Hexanoic acid, 4-ethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Hexanoic acid, 4-ethyl-(6299-66-7)
• EPA Substance Registry System: Hexanoic acid, 4-ethyl-(6299-66-7)

Safety Data

• Hazardous Substances Data: 6299-66-7(Hazardous Substances Data)

Usage

General Description

Hexanoic acid, 4-ethyl- is a chemical compound with the molecular formula C8H16O2. It is a carboxylic acid with a six-carbon chain and a methyl group attached to the fourth carbon. It is commonly found in foods such as cheese, butter, and milk, and is responsible for their characteristic odor. It is also used in the production of flavoring agents, perfumes, and pharmaceuticals. Hexanoic acid, 4-ethyl- is also known for its antimicrobial properties and is used as a preservative in some skincare and cosmetic products. Additionally, it is used as a precursor in the synthesis of other organic compounds.

InChI:InChI=1/C8H16O2/c1-3-7(4-2)5-6-8(9)10/h7H,3-6H2,1-2H3,(H,9,10)

Upstream product

• 97-96-1 2-Ethylbutyraldehyde 
• 73908-04-0 triethylcarbinyl bromide 
• 124-38-9 carbon dioxide 
• 37549-80-7 ethyl 4-ethyl-2-hexenoate 
• 2979-87-5 methyl 4-ethylhexanoate 
• 584-02-1 2-pentanol 
• 616-20-6 3-chloropentane 
• 1191453-87-8 2-(2-ethyl-butyl)-malonic acid 
• 87986-82-1 tris(2-acetoxyethyl)methane 
• 26456-63-3 3-vinylpenta-1,4-diene 
• 53378-75-9 3-(2-hydroxyethyl)pentane-1,5-diol 
• 96-22-0 pentan-3-one 
• 100340-03-2 C₁₆H₂₂O₃ 
• 55665-80-0 4-Ethyl-hex-3-enoic acid 

Downstream Products

• 88-09-5 2-Ethylbutanoic acid 

Relevant articles and documents

CATALYTIC CARBOXYLATION OF ACTIVATED ALKANES AND/OR OLEFINS

The present invention relates to a method of reacting starting materials with an activating group, namely alkanes carrying a leaving group and/or olefins, with carbon dioxide under transition metal catalysis to give carboxyl group-containing products. It is a special feature of the method of the present invention that the carboxylation predominantly takes place at a preferred position of the molecule irrespective of the position of the activating group. The carboxylation position is either an aliphatic terminus of the molecule or it is a carbon atom adjacent to a carbon carrying an electron withdrawing group. The course of the reaction can be controlled by appropriately choosing the reaction conditions to yield the desired regioisomer.

A facile synthesis of racemic 4-ethyl fatty acids

The synthesis of racemic 4-ethyl fatty acids is reported. A Grignard reagent was first prepared by 3-chloroalkane reacting with magnesium and then 4-ethyl fatty acid methyl esters were synthesised by coupling the Grignard reagent with methyl 3-bromopropionate in the presence of the catalyst Li 2CuCl4. The 4-ethyl fatty acid methyl esters were saponified and then acidified to give the 4-ethyl fatty acids. The syntheses of 4-ethylhexanoic acid, 4-ethylheptanoic acid, 4-ethyloctanoic acid, 4-ethylnonaoic acid and 4-ethyl decanoic acid are described. The structures of the 4-ethyl fatty acid methyl esters and 4-ethyl fatty acids were confirmed by 1H NMR, 13C NMR and HRMS.

PYRIDAZINONE GLUCOKINASE ACTIVATORS

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.