62596-65-0Relevant articles and documents
Synthesis of tubuvaline (Tuv) fragment of tubulysin via diastereoselective dihydroxylation of homoallylamine
Reddy, Ramesh B.,M, Vijay,Krishnan, Mena Asha,Chelvam, Venkatesh
supporting information, p. 797 - 809 (2020/12/13)
Tubulysins are natural anticancer molecules that directly bind and inhibit tubulin polymerization in actively dividing cells leading to apoptosis and cell death. Structurally, tubulysins are linear tetrapeptides, constituted by a natural amino acid (Ile)
Synthesis of the Deacetoxytubuvaline Fragment of Pretubulysin and its Lipophilic Analogues for Enhanced Permeability in Cancer Cell Lines
Reddy, Ramesh B.,Dudhe, Premansh,Chelvam, Venkatesh
supporting information, p. 77 - 81 (2019/01/04)
In the last two decades, tubulysins have emerged as alternatives to microtubule depolymerizing agents such as colchicine and vinblastine, which are well-established anticancer agents. However, the complex structure of tubulysins has always posed a challen
An efficient synthetic approach for N-C bond formation from (S)-amino acids: An easy access to cis-2,5-disubstituted chiral piperazines
Manna, Sudipta Kumar,Panda, Gautam
, p. 18332 - 18338 (2013/10/21)
An efficient synthetic strategy is described for the construction of amino acids derived enantiomerically pure cis-2,5-disubstituted chiral piperazines. Cu-catalyzed spontaneous regioselective ring opening and ring closing of non-activated N-tosyl aziridines as well as Pd-mediated N-C bond formation from N-tosyl halogenated amino-derivatives are the key steps for accessing disubstituted piperazines.