624729-74-4

Basic information

• Product Name: 8-Amino-3,4-dihydro-1H-naphthalen-2-one
• Synonyms: 8-Amino-3,4-dihydro-1H-naphthalen-2-one;8-aMino-3;8-aMino-1,2,3,4-tetrahydronaphthalen-2-one;8-AMino-3,4-dihydronaphthalen-2(1H)-one
• CAS NO: 624729-74-4
• Molecular Formula: C₁₀H₁₁NO
• Molecular Weight: 161.2
• Product Categories: API intermediates
• Mol File: 624729-74-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 348.3°C at 760 mmHg
• Flash Point: 164.4°C
• Appearance: /
• Density: 1.193g/cm³
• Vapor Pressure: 5.08E-05mmHg at 25°C
• Refractive Index: 1.619
• CAS DataBase Reference: 8-Amino-3,4-dihydro-1H-naphthalen-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Amino-3,4-dihydro-1H-naphthalen-2-one(624729-74-4)
• EPA Substance Registry System: 8-Amino-3,4-dihydro-1H-naphthalen-2-one(624729-74-4)

Safety Data

• Hazardous Substances Data: 624729-74-4(Hazardous Substances Data)

Usage

General Description

8-Amino-3,4-dihydro-1H-naphthalen-2-one, also known as 2-amino-1-tetralone, is a chemical compound with the molecular formula C11H11NO. It is an amino derivative of tetralone, which is a bicyclic compound. This chemical is commonly used as an intermediate in the production of various pharmaceuticals and organic compounds. It can be synthesized through the reduction of 2-nitro-1-tetralone or by the reduction of the corresponding ketone. 8-Amino-3,4-dihydro-1H-naphthalen-2-one is a white to yellow solid with a melting point of around 130-132°C, and it is considered to be a valuable building block in the synthesis of other chemical compounds.

InChI:InChI=1/C10H11NO/c11-10-3-1-2-7-4-5-8(12)6-9(7)10/h1-3H,4-6,11H2

Upstream product

• 1254716-28-3 tert-butyl N-(7-oxo-5,6,7,8-tetrahydronaphthalen-1-yl)carbamate 
• 624729-63-1 (7-ethoxy-naphthalen-1-yl)-carbamic acid t-butyl ester 
• 624729-65-3 (7-ethoxy-5,8-dihydronaphthalen-1-yl)amine 

Downstream Products

• 624729-66-4 8-amino-1,2,3,4-tetrahydronaphthalen-2-ol 
• 851266-44-9 benzyl(7-oxo-5,6,7,8-tetrahydronaphthalen-1-yl)carbamate 
• 851266-40-5 N-benzyl-7-methylene-5,6,7,8-tetrahydro-naphthalen-1-amine 
• 851266-46-1 benzyl [7-(hydroxymethyl)-5,6,7,8-tetrahydronaphthalen-1-yl]carbamate 
• 711016-22-7 N-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-4-iodobenzamide 
• 711016-15-8 3',4'-difluoro-N-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)biphenyl-4-carboxamide 
• 711015-38-2 N-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-N'-(4'-methylbiphenyl-3-yl)urea 
• 711016-20-5 2-biphenyl-3-yl-N-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)acetamide 
• 711016-23-8 2-(3-bromophenyl)-N-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)acetamide 
• 710954-91-9 N-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-N'-[3-piperidin-1-yl-4-(trifluoromethyl)benzyl]urea 
• 851266-45-0 benzyl[(7E)-7-(methoxymethylene)-5,6,7,8-tetrahydronaphthalen-1-yl]carbamate 
• 851266-41-6 N-benzyl-7-methyl-5,6,7,8-tetrahydronaphthalen-1-amine 
• 624729-72-2 (7-hydroxy-5,6,7,8-tetrahydro-naphthalen-1-yl)-carbamic acid phenyl ester 
• 851266-39-2 8-(benzylamino)-3,4-dihydronaphthalen-2(1H)-one 

Relevant articles and documents

Tetrahydro-naphthols as orally available TRPV1 inhibitors

Starting from a naphthol-based lead series with low oral bioavailability, we have identified potent TRPV1 antagonists with oral bioavailability in rats. These compounds emerged from SAR studies aimed at replacing the lead's phenol structure whilst maintai

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HYDROXY-TETRAHYDRO-NAPHTHALENYLUREA DERIVATIVES

This invention relates to hydroxy-tetrahydro-naphthalenylurea derivatives and salts thereof which are useful as active ingredients of pharmaceutical preparations. The hydroxy-tetrahydro-naphthalenylurea derivatives of the present invention have an excelle