624-18-0 Usage
Chemical Description
P-phenylenediamine dihydrochloride is a chemical used in the production of hair dyes and other cosmetic products.
Description
p-Phenylenediamine dihydrochloride, also known as paraphenylenediamine, is an organic compound commonly used as a hair dye component and a contact allergen for the treatment of inflammatory diseases. It is the dihydrochloride salt of 1,4-Phenylenediamine (P319845) and plays a significant role in various applications across different industries.
Uses
Used in Hair Dye Industry:
p-Phenylenediamine dihydrochloride is used as a hair dye component for coloring keratinous materials. It is utilized in combination with at least one self-oxidizing dye or a blue, purple, or green oxidative dye, as well as at least one fluorescent dye, to achieve the desired color and enhance the overall appearance of the hair.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, p-Phenylenediamine dihydrochloride serves as a contact allergen for the treatment of inflammatory diseases. Its allergenic properties make it a valuable component in the development of medications aimed at managing inflammation and related conditions.
Used in Research and Development:
p-Phenylenediamine dihydrochloride is also used in research and development for the study of its chemical properties and potential applications in various fields. Its unique structure and reactivity make it an interesting subject for scientific investigation and the development of new products and technologies.
Air & Water Reactions
Water soluble.
Reactivity Profile
Acidic organic/inorganic salts, such as p-Phenylenediamine dihydrochloride, are generally soluble in water. The resulting solutions contain moderate to high concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions.
Fire Hazard
Flash point data for p-Phenylenediamine dihydrochloride are not available; however, p-Phenylenediamine dihydrochloride is probably combustible.
Check Digit Verification of cas no
The CAS Registry Mumber 624-18-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,2 and 4 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 624-18:
(5*6)+(4*2)+(3*4)+(2*1)+(1*8)=60
60 % 10 = 0
So 624-18-0 is a valid CAS Registry Number.
InChI:InChI=1/C6H8N2.2ClH/c7-5-1-2-6(8)4-3-5;;/h1-4H,7-8H2;2*1H
624-18-0Relevant articles and documents
Cobalt-Catalyzed Deoxygenative Hydroboration of Nitro Compounds and Applications to One-Pot Synthesis of Aldimines and Amides
Gudun, Kristina A.,Hayrapetyan, Davit,Khalimon, Andrey Y.,Segizbayev, Medet,Slamova, Ainur,Zakarina, Raikhan
, (2021/11/30)
The commercially available and bench-stable Co(acac)2 ligated with bis[(2-diphenylphosphino)phenyl] ether (dpephos) was employed for selective room temperature hydroboration of nitro compounds with HBPin (TOF up to 4615 h?1), tolerating halide, hydroxy, amino, ether, ester, lactone, amide and heteroaromatic functionalities. These reactions offered a direct access to a variety of N-borylamines RN(H)BPin, which were in situ treated with aldehydes and carboxylic acids to produce a series of aldimines and secondary carboxamides without the need for dehydrating and/or coupling reagents. Combination of these transformations in a sequential one-pot manner allowed for direct and selective synthesis of aldimines and secondary carboxamides from readily available and inexpensive nitro compounds.
A Modular Phosphorylated Glycoluril-Derived Molecular Tweezer for Potent Binding of Aliphatic Diamines
Heilmann, Michael,Tiefenbacher, Konrad
supporting information, p. 12900 - 12904 (2019/11/05)
A molecular tweezer based on a glycoluril-derived framework bearing four phosphate groups was synthesized and shown to be capable of binding organic amines in aqueous solution. This work reports the Ka values for 30 complexes of this molecular tweezer and amine guests, determined by means of 1H NMR titrations. Both the hydrophobic cavity and the phosphate groups contribute to the binding. Bulkier molecules and molecules bearing negatively charged groups like carboxylates in amino acids bind less tightly due to a steric clash and coulombic repulsion. The narrow cavity and the strong ionic interactions of the phosphate groups with ammonium guests favor binding of aliphatic diamines. These binding properties clearly distinguish this system from structurally related molecular clips and tweezers.
FRICTIONLESS MOLECULAR ROTARY MOTORS
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Page/Page column 33, (2010/02/17)
A rotaxane consisting of a cucurbituril and an uncharged guest molecule, having low or null affinity therebetween is provided as well as processes for providing the same. Various uses as energy converters (“frictionless” molecular motors), biochips and biosensors using the same are also provided.