621-76-1 Usage
Description
Tripropyl orthoformate is an organic compound that is used as a reagent in various chemical reactions. It is a colorless liquid with a characteristic odor and is soluble in water.
Uses
Used in Lipase-Catalyzed Esterification:
Tripropyl orthoformate is used as an alcohol donor in the lipase-catalyzed esterification aimed at the kinetic resolution of racemic acids. It helps to circumvent the adverse effects of the water formed during the reaction, allowing for more efficient and selective esterification.
Used in Esterification of Rac-Fenoprofen:
Tripropyl orthoformate is used as an alcohol donor to investigate the activity and enantioselectivity of Novozym 435 in the esterification of rac-fenoprofen in methylcyclohexane. This allows for the production of enantiomerically pure compounds, which are important in the pharmaceutical industry.
Used in Synthesis of Squaraine Derivatives:
Tripropyl orthoformate may be used as a drying agent during the synthesis of squaraine derivatives. It helps to remove moisture from the reaction mixture, preventing unwanted side reactions and improving the yield of the desired product.
Synthesis Reference(s)
Journal of the American Chemical Society, 77, p. 3801, 1955 DOI: 10.1021/ja01619a036
Check Digit Verification of cas no
The CAS Registry Mumber 621-76-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,2 and 1 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 621-76:
(5*6)+(4*2)+(3*1)+(2*7)+(1*6)=61
61 % 10 = 1
So 621-76-1 is a valid CAS Registry Number.
InChI:InChI=1/C10H22O3/c1-4-7-11-10(12-8-5-2)13-9-6-3/h10H,4-9H2,1-3H3
621-76-1Relevant articles and documents
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Alexander,Busch
, p. 554 (1952)
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Synthesis and Application of α,ω-Bis(dialkylamino)oligooxaalkanes and Their Analogs as Phase-Transfer Catalysts in Heterogeneous Synthesis of Trialkyl Orthoformates
Shtamburg, V. G.,Skobelev, O. L.,Grinev, V. M.,Dmitrienko, A. D.,Pleshkova, A. P.,Pritykin, L. M.
, p. 609 - 612 (2007/10/03)
α,ω-Bis(dialkylamino)oligooxaalkanes, 1,8-bis(alkoxyamino)-3,6-dioxaoctanes, and 1,8-bis(diethylamino)-3,6-dioxaoctane N,N'-dioxide are efficient phase-transfer catalysts, the use of which ensures preparation in high yields of trialkyl orthoformates from chloroform and primary alcohols in the heterogeneous systems CH2Cl2-solid alkali metal hydroxide.
On the Mechanism of Acetalization Reactions with Carboxamide-Dialkyl Sulfate Adducts; a New Method of Preparation of Orthocarboxylic Esters and of Cleavage of Carboxamides.
Kantlehner, Willi,Gutbrod, Heinz-Dieter
, p. 1677 - 1688 (2007/10/02)
It is shown that the efficiency of carboxamide-dialkyl-sulfate adducts in acetalization reactions depends on their alkylation ability.A mechanism of acetal formation using orthoformates as acetalization reagents is proposed.Alcoholysis of carboxamide-dialkyl sulfate adducts 1b, 11, 13 affords orthocarboxylic esters.Carboxamides and carboxmorpholides react with dimethyl sulfate/methanol to give methyl esters.