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  • 62058-13-3 Structure
  • Basic information

    1. Product Name: Cis-4-Aminoadamantan-1-ol
    2. Synonyms: Cis-4-Aminoadamantan-1-ol;CL226
    3. CAS NO:62058-13-3
    4. Molecular Formula: C10H17NO
    5. Molecular Weight: 167.24808
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 62058-13-3.mol
    9. Article Data: 26
  • Chemical Properties

    1. Melting Point: >250℃ (SUB.)
    2. Boiling Point: 276℃
    3. Flash Point: 120℃
    4. Appearance: /
    5. Density: 1.205
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: Cis-4-Aminoadamantan-1-ol(CAS DataBase Reference)
    10. NIST Chemistry Reference: Cis-4-Aminoadamantan-1-ol(62058-13-3)
    11. EPA Substance Registry System: Cis-4-Aminoadamantan-1-ol(62058-13-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 62058-13-3(Hazardous Substances Data)

62058-13-3 Usage

Description

Cis-4-Aminoadamantan-1-ol, a derivative of adamantane, is a white, crystalline solid with the molecular formula C10H17NO. It is soluble in both water and organic solvents and has potential applications in the pharmaceutical industry, particularly for the development of drugs targeting neurological and psychiatric disorders. Additionally, it is being studied for its potential antiviral and antimalarial properties.

Uses

Used in Pharmaceutical Industry:
Cis-4-Aminoadamantan-1-ol is used as a building block in organic chemistry for the synthesis of pharmaceuticals, particularly for the development of drugs targeting neurological and psychiatric disorders. Its unique structure and properties make it a promising candidate for drug discovery and design.
Used in Medicinal Chemistry:
Cis-4-Aminoadamantan-1-ol is used as a key intermediate in the synthesis of various medicinal compounds. Its versatile chemical properties allow for the development of novel therapeutic agents with potential applications in treating a wide range of diseases and conditions.
Used in Antiviral Research:
Cis-4-Aminoadamantan-1-ol is being studied for its potential antiviral properties. Its unique structure and interactions with biological targets may offer new avenues for the development of antiviral drugs, particularly against challenging viral infections.
Used in Antimalarial Research:
Cis-4-Aminoadamantan-1-ol is also being investigated for its potential antimalarial properties. Its ability to target specific biological pathways involved in malaria parasite replication and survival may lead to the development of new antimalarial drugs, addressing the growing need for effective treatments against drug-resistant strains of the disease.

Check Digit Verification of cas no

The CAS Registry Mumber 62058-13-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,2,0,5 and 8 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 62058-13:
(7*6)+(6*2)+(5*0)+(4*5)+(3*8)+(2*1)+(1*3)=103
103 % 10 = 3
So 62058-13-3 is a valid CAS Registry Number.
InChI:InChI=1S/C10H17NO/c11-9-7-1-6-2-8(9)5-10(12,3-6)4-7/h6-9,12H,1-5,11H2/t6?,7-,8?,9?,10-/m0/s1

62058-13-3Relevant articles and documents

An expeditious preparation of E-2-amino-5-hydroxyadamantane and its Z-isomer

Jaroskova, Libuse,Van der Veken, Louis,de Belser, Paul,Diels, Gaston,de Groot, Alex,Linders, Joannes T.M.

, p. 8063 - 8067 (2006)

Reductive amination of 5-hydroxy-2-adamantanone with S-α-methylbenzylamine using 5% Rh-C as the catalyst in the presence of Al(iOPr)3 gave a 3:1 mixture of the E- and Z-5-hydroxy-adamantane-1-phenethylamines. Choice of catalyst, concentration,

Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor

Hamaguchi, Hisao,Amano, Yasushi,Moritomo, Ayako,Shirakami, Shohei,Nakajima, Yutaka,Nakai, Kazuo,Nomura, Naoko,Ito, Misato,Higashi, Yasuyuki,Inoue, Takayuki

, p. 4971 - 4983 (2018/08/29)

Janus kinases (JAKs) are considered promising targets for the treatment of autoimmune diseases including rheumatoid arthritis (RA) due to their important role in multiple cytokine receptor signaling pathways. Recently, several JAK inhibitors have been developed for the treatment of RA. Here, we describe the identification of the novel orally bioavailable JAK inhibitor 18, peficitinib (also known as ASP015K), which showed moderate selectivity for JAK3 over JAK1, JAK2, and TYK2 in enzyme assays. Chemical modification at the C4-position of lead compound 5 led to a large increase in JAK inhibitory activity and metabolic stability in liver microsomes. Furthermore, we determined the crystal structures of JAK1, JAK2, JAK3, and TYK2 in a complex with peficitinib, and revealed that the 1H-pyrrolo[2,3–b]pyridine-5-carboxamide scaffold of peficitinib forms triple hydrogen bonds with the hinge region. Interestingly, the binding modes of peficitinib in the ATP-binding pockets differed among JAK1, JAK2, JAK3, and TYK2. WaterMap analysis of the crystal structures suggests that unfavorable water molecules are the likely reason for the difference in orientation of the 1H-pyrrolo[2,3-b]pyridine-5-carboxamide scaffold to the hinge region among JAKs.

Adamantyl analogues of paracetamol as potent analgesic drugs via inhibition of TRPA1

Fresno, Nieves,Prez-Fernndez, Ruth,Goicoechea, Carlos,Alkorta, Ibon,Fernndez-Carvajal, Asia,De La Torre-Martnez, Roberto,Quirce, Susana,Ferrer-Montiel, Antonio,Martn, M. Isabel,Goya, Pilar,Elguero, Jos

, (2015/04/16)

Paracetamol also known as acetaminophen, is a widely used analgesic and antipyretic agent. We report the synthesis and biological evaluation of adamantyl analogues of paracetamol with important analgesic properties. The mechanism of nociception of compoun

2, 4 -DIAMINOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS

-

Page/Page column 68-69, (2012/05/20)

The present invention relates to novel pyrimide derivatives of formula (I): that are useful as kinase inhibitors. More particularly, the present invention relates to novel pyrimidine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative disorders.

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