62-55-5 Usage
Description
Thioacetamide (TAA) is a synthetic, colorless or white crystalline compound with a slight mercaptan odor. It is not found in nature and is prepared by heating ammonium acetate and aluminum sulfide. Thioacetamide is a combustible compound with a melting point of 113-114℃ and is soluble in water and ethanol, but only slightly soluble in benzene and ether. Its solution is stable at room temperature or 50-60℃, but it can decompose quickly in the presence of hydrogen ions, generating thiosulfate hydrogen.
Uses
1. Thioacetamide is used as a catalyst, stabilizer, polymerization inhibitor, electroplating additive, photographic chemical, pesticide, dyeing auxiliary, and processing agent in various industries.
2. Thioacetamide is used as a polymer curing agent, crosslinking agent, rubber additive, and pharmaceutical raw material.
3. Thioacetamide is used as a vulcanizing agent and crosslinking agent in the polymer and rubber industries, as well as a pharmaceutical raw material.
4. Thioacetamide is used as an analytical reagent in the field of chemistry.
5. Thioacetamide is used as an intermediate in organic synthesis.
6. Thioacetamide is used for sulfide generation in chemical processes.
7. Thioacetamide serves as a substitute for hydrogen sulfide (H2S) in laboratory qualitative analyses.
8. Thioacetamide has been used in the synthesis of [email?protected] nano-array core-shell structures.
Organic reagents
Thioacetamide is organic reagent, it is colorless or white crystalline flake. It is dissolved in water, ethanol, very slightly soluble in benzene, ether, the aqueous solution at room temperature or 50~60℃ is fairly stable, when placed 2 to 3 weeks, it is not change, but when hydrogen ions is in the presence, it quickly decomposes into hydrogen sulfide , but hydrolysis increases with alkalinity or acidity of the solution and the temperature rises quickly. Hydrolysis equations solution of thioacetamide in acidic and basic is:
Acidic solution: CH3CSNH2 + 2H2O----(NH4 +) + CH3COO-+ H2S
Alkaline solution: CH3CSNH2 + 2OH-----NH3 + CH3COO-+ HS-
Since H2S or HS-can generate for hydrolysis in acidic or alkaline solution, so in analytical chemistry, it is often used in place of toxic and odor H2S, as the metal cation group reagents or precipitation reagents. The property of resulting precipitate is good, easy to separate. In addition, it can also be used for bismuth measurement reagent. Preparation method: It can be prepared by heating the acetamide with aluminum sulfide, hydrogen sulfide reacting with acetonitrile, or acetamide reacting with K3PS4.
Production method
Thioacetamide can be obtained by the reaction of acetonitrile with hydrogen sulfide, or acetamide with phosphorus pentasulfide.
Air & Water Reactions
Slightly water soluble.
Reactivity Profile
Thioacetamide reacts with aqueous acid to generate hydrogen sulfide. Forms addition compounds and sulfides with salts of heavy metals. Hydrolyzed by acids or bases .
Hazard
Toxic by ingestion and inhalation, a possible
carcinogen.
Health Hazard
The toxicity of this compound is moderatein rats; an oral lethal dose is 200 mg/kg.Oral administration of thioacetamide causedliver cancer in rats and mice. It is, however, a weak liver carcinogen. Malvaldi and associates (1988) investigated the mechanism of its carcinogenic activity on rat liver.Whereas the initiating ability of this compound is quite low, its promoting effect isstrong. Thus thioacetamide is a very effectivepromoter of the liver carcinogenesis. A similar promoting activity of liver carcinogenesishas been observed with other thioamide substances, such as thiobenzamide (Malvaldi et al. 1986). Low et al. (2004) have proposed a modelto explain thioacetamide-induced hepatotoxicity and cirrhosis in rat livers. The pathways of thioacetamide-induced liver fibrosiswere found to be initiated by thioacetamideS-oxide derived from the biotransformationof thioacetamide by the microsomal flavinadenine nucleotide containing monooxygenase and cytochrome P450 systems andinvolve oxidative stress and depletion ofsuccinyl-CoA, thus affecting heme and ironmetabolism. Karabay et al. (2005) observedsuch hepatic damage in rats with elevationof total nitrite level in livers and decrease inarginase activity. The authors have reportedthat nitrosative stress was essentially the critical factor in thioacetamide-induced hepaticfailure in rats.Pretreatment of rats with jigrine exhibited hepatoprotective action againstthioacetamide-induced toxicity (Ahmed et al.1999). Thioacetamide decreased the concentration of glutathione in the liver of rats.Jigrine pretreatment, however, restored theglutathione levels to the near normal values.The authors claimed that the effects of jigrinewere comparable to that of silymarin. Thehepatotoxicity in rats was found to potentiatefollowing pretreatment with phenobarbital.Al-Bader et al. (2000) investigated thetoxicity of thioacetamide in the spleen inexperimental animals. The authors foundan intimate association between the levelsof trace metals and spleen pathology, asobserved in studies of other organs.
Fire Hazard
Flash point data on Thioacetamide are not available; Thioacetamide is probably combustible.
Safety Profile
Confirmed carcinogen
with experimental carcinogenic,
neoplas tigenic, tumorigenic, and teratogenic
data. Poison by ingestion and intraperitoneal
routes. Moderately toxic by subcutaneous
route. Human mutation data reported. An
experimental teratogen. Experimental
reproductive effects. Exposure has caused
liver damage. When heated to
decomposition it emits very toxic fumes of
NOx and SOx. See also SULFIDES and
MERCAPTANS.
Potential Exposure
Thioacetamide is used as a replacement for hydrogen sulfide in qualitative analyses. Thioacetamide has been used as an organic solvent in the leather, textile, and paper industries; as an accelerator in the vulcanization of buna rubber; and as a stabilizer of motor fuel.
Carcinogenicity
Thioacetamide is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals.
Environmental Fate
TAA’s production and use as a substitute for hydrogen sulfide in
the laboratory may result in its release to the environment
through various waste streams. If released to air, TAA’s estimated
vapor pressure indicates that it will exist solely as a vapor
in the ambient atmosphere. Vapor-phase TAA will be degraded
in the atmosphere by reaction with photochemically produced
hydroxyl radicals; the half-life for this reaction in air is estimated
to be 18 h. TAA was not biodegraded by activated sludge
after 5 days, and therefore may be resistant to biodegradation
in the environment. Hydrolysis is not expected since amides
hydrolyze very slowly under environmental conditions. An
estimated bioconcentration factor for TAA suggests that the
potential for bioconcentration in aquatic organisms is low. TAA
is expected to be highly mobile in soil, and to volatilize into the
atmosphere from moist soil surfaces. In an aquatic environment,
most of the substance will leave via volatilization and is
not expected to adsorb to solids.
Purification Methods
Crystallise the amide from absolute diethyl ether or *benzene. Dry it at 70o in a vacuum and store it over P2O5 at 0o under nitrogen. (It develops an obnoxious odour on storage, and absorption at 269nm decreases, hence it should be freshly recrystallised before use). [Beilstein 2 IV 565.]
Toxicity evaluation
TAA acts as an indirect hepatotoxin and causes parenchymal
cell necrosis. It can be metabolized in vivo to acetamide, which
itself is carcinogenic. Acetamide is then hydrolyzed to acetate.
TAA-induced liver necrosis has been explained by a scheme that
includes the metabolic conversion of TAA to its S-oxide, followed
by the further metabolism of TAA-S-oxide to a reactive
intermediate that can either bind to liver macromolecules or be
further degraded to acetamide and polar products. Examples of
TAA’s biochemical effects in the liver include glucose-6-
phosphate dehydrogenase being induced within days after rats
are treated with TAA, and the level of urea product is decreased
as are the activities of hepatic carbamyl phosphate synthetase,
ornithine transcarbamylase, and arginase. Thus, TAA can
produce marked disturbances in the urea cycle in the liver.
Further, TAA administered to rats leads to functional disturbances
in mitochondria isolated from livers after 24 h, and
the maximum respiratory activity of the mitochondria is
also depressed, mitochondrial Ca2+ content is significantly
increased, and the Ca2+ transport behavior of the hepatic
mitochondria is altered. The results are indicative of structural
alterations of the inner mitochondrial membranes. The
potential role of TAA in the initiation phase of carcinogenesis
may be associated with an increase in nucleoside triphosphate
activity in cell nuclear envelopes with a corresponding increase
in RNA transport activity. Alterations in the transport
phenomenon of nuclear RNA sequences are considered an
early response to carcinogens.
Incompatibilities
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.
Waste Disposal
Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Treatment in an incinerator, boiler or cement kiln.
Check Digit Verification of cas no
The CAS Registry Mumber 62-55-5 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 6 and 2 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 62-55:
(4*6)+(3*2)+(2*5)+(1*5)=45
45 % 10 = 5
So 62-55-5 is a valid CAS Registry Number.
InChI:InChI=1/C2H5NS/c1-2(3)4/h1H3,(H2,3,4)
62-55-5Relevant articles and documents
A convenient synthesis of derivatives of 1,3,2-dioxaphosphocane-2-sulfide with bioacitivity via Lawesson's reagent
Luo, Yanping,He, Liangnian,Ding, Mingwu,Yang, Guangfu,Luo, Aihong,Liu, Xiaopeng,Wu, Tianjie
, p. 37 - 41 (2001)
Lawesson's reagent, 2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disufide, reacted with the substituted 1,5-bisphenol 1to afford derivatives of 1,3,2-dioxaphosphocane-2-sulfide 2, which were found to possess selective herbicidal activity against rape.
Length-Selective Synthesis of Acylglycerol-Phosphates through Energy-Dissipative Cycling
Bonfio, Claudia,Caumes, Cécile,Duffy, Colm D.,Patel, Bhavesh H.,Percivalle, Claudia,Tsanakopoulou, Maria,Sutherland, John D.
supporting information, p. 3934 - 3939 (2019/03/08)
The main aim of origins of life research is to find a plausible sequence of transitions from prebiotic chemistry to nascent biology. In this context, understanding how and when phospholipid membranes appeared on early Earth is critical to elucidating the prebiotic pathways that led to the emergence of primitive cells. Here we show that exposing glycerol-2-phosphate to acylating agents leads to the formation of a library of acylglycerol-phosphates. Medium-chain acylglycerol-phosphates were found to self-assemble into vesicles stable across a wide range of conditions and capable of retaining mono- and oligonucleotides. Starting with a mixture of activated carboxylic acids of different lengths, iterative cycling of acylation and hydrolysis steps allowed for the selection of longer-chain acylglycerol-phosphates. Our results suggest that a selection pathway based on energy-dissipative cycling could have driven the selective synthesis of phospholipids on early Earth.
Synthesis and biological evaluation of 2,4,5-trisubstituted thiazoles as antituberculosis agents effective against drug-resistant tuberculosis
Karale, Uttam B.,Krishna, Vagolu Siva,Krishna, E. Vamshi,Choudhari, Amit S.,Shukla, Manjulika,Gaikwad, Vikas R.,Mahizhaveni,Chopra, Sidharth,Misra, Sunil,Sarkar, Dhiman,Sriram, Dharmarajan,Dusthackeer, V.N. Azger,Rode, Haridas B.
, p. 315 - 328 (2019/06/14)
The dormant and resistant form of Mycobacterium tuberculosis presents a challenge in developing new anti-tubercular drugs. Herein, we report the synthesis and evaluation of trisubstituted thiazoles as antituberculosis agents. The SAR study has identified a requirement of hydrophobic substituent at C2, ester functionality at C4, and various groups with hydrogen bond acceptor character at C5 of thiazole scaffold. This has led to the identification of 13h and 13p as lead compounds. These compounds inhibited the dormant Mycobacterium tuberculosis H37Ra strain and M. tuberculosis H37Rv selectively. Importantly, 13h and 13p were non-toxic to CHO cells. The 13p showed activity against multidrug-resistant tuberculosis isolates.