61791-12-6

Basic information

• Product Name: Cremophor EL
• Synonyms: polyoxyethylene castor oil;POLYOXYETHYLENE(10) CASTOR OIL;POLYETHYLENEGLYCOL CASTOR OIL;Castoroil,ethyleneglycolpolymer;Castoroil,ethyleneoxidereactionproduct;Castoroil,polyethoxylated;castoroilpolyoxyethyleneether;polyethoxylatedcastoroil
• CAS NO: 61791-12-6
• Molecular Formula: NULL
• Molecular Weight: 0
• EINECS: 500-147-5
• Product Categories: Detergents;Detergents A to ZDetergents;Non-Ionic
• Mol File: 61791-12-6.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 232.6℃[at 101 325 Pa]
• Flash Point: 257℃
• Appearance: Clear yellow/Viscous Liquid
• Density: 1.05 g/mL at 20 °C
• Vapor Pressure: 0Pa at 25℃
• Storage Temp.: REFRIGERATOR (+4C)
• PKA: 0[at 20 ℃]
• Water Solubility: 24.11mg/L at 25℃
• Stability: Stable. Incompatible with storng oxidizing agents.
• CAS DataBase Reference: Cremophor EL(CAS DataBase Reference)
• NIST Chemistry Reference: Cremophor EL(61791-12-6)
• EPA Substance Registry System: Cremophor EL(61791-12-6)

Safety Data

• WGK Germany: 1
• RTECS: GO5661000
• Hazardous Substances Data: 61791-12-6(Hazardous Substances Data)

Usage

Description

Cremophor EL, also known as Polyoxyl 35 Castor Oil, is a non-ionic surfactant derived from castor oil. It is a mixture of polyethylene glycol esters with hydrophilic and lipophilic properties, making it an effective solubilizer and emulsifier in various applications.

Uses

Used in Pharmaceutical Industry:
Cremophor EL is used as a solubilizer and emulsifier for improving the solubility of poorly water-soluble drugs and enhancing their transmembrane permeation. It helps in the formulation of liquid dosage forms, such as oral solutions, suspensions, and injectables, and increases the bioavailability of drugs.
Used in Cosmetic Industry:
Cremophor EL is used as an emulsifier and surfactant in the formulation of creams, lotions, and ointments. It helps in stabilizing oil-in-water or water-in-oil emulsions, providing a smooth texture and improving the spreadability of the products on the skin.
Used in Food Industry:
Cremophor EL is used as an emulsifier and stabilizer in the food industry, particularly in the production of ice cream, chocolate, and confectionery products. It helps in maintaining the consistency, texture, and shelf life of these products.
Used in Agrochemical Industry:
Cremophor EL is used as an adjuvant in agrochemical formulations, such as herbicides, insecticides, and fungicides. It enhances the solubility, dispersion, and absorption of active ingredients, improving the efficacy and performance of these products.
Used in Detergent Industry:
Cremophor EL is used as a detergent to improve the solubility of dyes and increase the transmembrane permeation. It helps in the removal of stains and dirt from various surfaces, making it suitable for use in laundry detergents, dishwashing liquids, and cleaning agents.
Used in Drug Delivery Systems:
Cremophor EL is used as a vehicle for drug/stimulant delivery in cells. It helps in the encapsulation and controlled release of drugs, improving their therapeutic efficacy and reducing side effects. It is particularly useful in the development of targeted drug delivery systems, such as liposomes, nanoparticles, and micelles, for various medical applications.

Flammability and Explosibility

Notclassified

Biochem/physiol Actions

Kolliphor? EL is used in lipid-based formulations for drugs and solubilization of cosmetics. Kolliphor EL is suitable for the production of semi-solid and liquid formulations of water-insoluble actives and other hydrophobic compounds. Due to its emulsification functionality, it finds application in biological membrane- based drug transport studies.