6142-15-0

Basic information

• Product Name: 2-AMINO-4-METHYLTHIAZOLE HYDROCHLORIDE
• Synonyms: TOSLAB 14877;2-AMINO-4-METHYLTHIAZOLE HCL;2-AMINO-4-METHYLTHIAZOLE HYDROCHLORIDE;2-amino-4-methylthiazolemonohydrochloride;2-amino-4-methyl-thiazolmonohydrochloride;4-methyl-2-thiazolaminmonohydrochloride;4-Methyl-2-thiazolamine hydrochloride;Nsc265334
• CAS NO: 6142-15-0
• Molecular Formula: C₄H₆N₂S*ClH
• Molecular Weight: 150.63
• Mol File: 6142-15-0.mol
• Article Data: 1

Chemical Properties

• Melting Point: 173 °C
• Boiling Point: 232.5 °C at 760 mmHg
• Flash Point: 94.4 °C
• Appearance: /
• Vapor Pressure: 0.0588mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• Water Solubility: almost transparency
• CAS DataBase Reference: 2-AMINO-4-METHYLTHIAZOLE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-4-METHYLTHIAZOLE HYDROCHLORIDE(6142-15-0)
• EPA Substance Registry System: 2-AMINO-4-METHYLTHIAZOLE HYDROCHLORIDE(6142-15-0)

Safety Data

• RTECS: XJ2630000
• HazardClass: IRRITANT
• Hazardous Substances Data: 6142-15-0(Hazardous Substances Data)

Usage

General Description

2-Amino-4-methylthiazole hydrochloride is a specialized chemical compound identified by the CAS number 53222-56-5. This substance belongs to the family of thiazoles, which are heterocyclic compounds characterized by a ring structure consisting of four carbon atoms and one nitrogen atom. The specific structure of 2-Amino-4-methylthiazole hydrochloride also includes a chlorine atom, included in its hydrochloride form, and an amino group (-NH2) which contributes to its broad range of potential chemical reactions. It is often used in scientific research, particularly in the synthesis of other complex chemical compounds. Its handling requires safety precautions as direct contact or inhalation can cause irritation to skin, eyes, and respiratory system.

InChI:InChI=1/C4H6N2S.ClH/c1-3-2-7-4(5)6-3;/h2H,1H3,(H2,5,6);1H

Upstream product

• 294886-88-7 2-(4-oxothiazolidine-2-iminyl)thiazol-4-acetic acid ethyl ester 

Downstream Products

• 5316-76-7 5-chloro-4-methylthiazol-2-amine 
• 71119-13-6 N-(4-{[(4-methyl-2-thiazolyl)amino]sulfonyl}phenyl)-acetamide 
• 133692-16-7 5-bromo-4-methyl-thiazol-2-ylamine; hydrochloride 
• 89179-76-0 (4-methyl-thiazol-2-yl)-urea 

Relevant articles and documents

Synthesis and antimicrobial activity of 4-carbethoxymethyl-2-[(α- haloacyl)amino]thiazoles and 5-nonsubstituted/substituted 2-[(4- carbethoxymethylthiazol-2-yl)imino]-4-thiazolidinones

4-Carbethoxymethyl-2-[(chloroacetyl/α-chloropropionyl/α- bromobutyryl/α-chloro-(α-phenylacetyl)amino]thiazoles (I-IV) were synthesized by reacting 4-carbethoxymethyl-2-aminothiazole with chloroacetyl chloride, α-chloropropionyl chloride, α-bromobutyryl bromide and α-chloro- α-phenylacetyl chloride, respectively. Furthermore, I-IV were refluxed with ammonium thiocyanate to give 2-[(4-carbethoxymethylthiazol-2-yl)imino]-4- thiazolidinones (V-VIII). V was refluxed with various aromatic aldehydes to give 5-arylidene-2-[(4-carbethoxymethylthiazol-2-yl)imino]-4-thiazolidinones (IX-XIV). The structures of synthesized compounds were confirmed by elemental analyses, hydrolysis, UV, IR, 1H-NMR and EI mass spectral data. The antimicrobial activities of the compounds were assessed by microbroth dilution technique using Mueller-Hinton broth and Mueller-Hinton Agar. In this study, Staphylococcus aureus ATCC 6538, Staphylococcus epidermidis ATCC 12228, Escherichia coli ATCC 8739, Klebsiella pneumoniae ATCC 4352, Pseudomonas aeruginosa ATCC 1539, Salmonella typhi, Shigella flexneri, Proteus mirabilis and Candida albicans ATCC 10231 were used as test microorganisms. Among the tested compounds, XI and XIV showed activity against S. aureus (MIC: 78 μg/ml, 1.6 μg/ml), whereas compound V had an activity against S. flexneri (MIC: 39 μg/ml) and compound I against C. albicans (MIC: 125 (μg/ml). Compounds I, IV-XIV were also evaluated for antituberculosis activity against Mycobacterium tuberculosis H37Rv using the BACTEC 460 radiometric system and BACTEC 12B medium. Only compounds I and XIV showed 86% and 67% inhibition in the primary screen.