6072-49-7

Basic information

• Product Name: 2-(2-THIENYL)BENZOIC ACID
• Synonyms: AKOS BAR-0195;2-THIEN-2-YLBENZOIC ACID;2-THIOPHEN-2-YL-BENZOIC ACID;2-(2-THIENYL)BENZOIC ACID;RARECHEM AL BE 1415;2-(2-Carboxyphenyl)thiophene
• CAS NO: 6072-49-7
• Molecular Formula: C₁₁H₈O₂S
• Molecular Weight: 204.25
• Mol File: 6072-49-7.mol
• Article Data: 14

Chemical Properties

• Melting Point: 92 °C
• Boiling Point: 342.1 °C at 760 mmHg
• Flash Point: 160.7 °C
• Appearance: /
• Density: 1.303 g/cm³
• Vapor Pressure: 2.96E-05mmHg at 25°C
• Refractive Index: 1.635
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(2-THIENYL)BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-THIENYL)BENZOIC ACID(6072-49-7)
• EPA Substance Registry System: 2-(2-THIENYL)BENZOIC ACID(6072-49-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 6072-49-7(Hazardous Substances Data)

Usage

Uses

2-Thien-2-ylbenzoic Acid (cas# 6072-49-7) is a compound useful in organic synthesis.

Synthesis Reference(s)

The Journal of Organic Chemistry, 35, p. 871, 1970 DOI: 10.1021/jo00829a001

InChI:InChI=1/C11H8O2S/c12-11(13)9-5-2-1-4-8(9)10-6-3-7-14-10/h1-7H,(H,12,13)

Upstream product

• 6165-68-0 thiophene boronic acid 
• 88-67-5 2-Iodobenzoic acid 
• 342-54-1 2-(methoxycarbonyl)benzenediazonium tetrafluoroborate 
• 134-20-3 2-carbomethoxyaniline 
• 1620194-08-2 N-(2-(pyridin-2-yl)propan-2-yl)benzamide-2-d₁ 
• 88-65-3 2-bromobenzoic-acid 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 615-36-1 2-bromoaniline 
• 610-94-6 2-bromobenzoic acid methyl ester 
• 17595-84-5 o-(2-thienyl)benzoic acid methyl ester 
• 124-38-9 carbon dioxide 
• 106851-53-0 2-(2’-bromophenyl)thiophene 
• 188290-36-0 thiophene 
• 1488-42-2 Diphenyliodonium-2-carboxylate 

Downstream Products

• 17595-84-5 o-(2-thienyl)benzoic acid methyl ester 
• 5706-08-1 4H-Indeno<1,2-b>thiophen-4-one 
• 194416-92-7 o-(5-formyl-2-thienyl)benzonitrile 
• 125610-77-7 1-cyano-2-(1-thiophenyl)-benzene 
• 1261275-76-6 C₃₄H₂₇N₃O₃S₂ 
• 106183-37-3 methyl 3-<2'-(2''-thienyl)phenyl>3-oxopropanoate 
• 91533-93-6 methyl 3-<2'-(2''-thienyl)phenyl>2-diazo-3-oxopropanoate 
• 154191-76-1 methyl diazo<2-(3,4,5-trichloro-2-thienyl)phenyl>acetate 
• 154191-78-3 methyl <2-(3,4,5,-trichloro-2-thienyl)phenyl>acetate 
• 154191-77-2 methyl <2-(2-thienyl)phenyl>acetate 
• 106183-47-5 α-diazo-2-(2-thienyl)acetophenone 

Relevant articles and documents

Palladium-catalyzed intramolecular aromatic C-H acylation of 2-arylbenzoyl fluorides

The catalytic intramolecular cyclization of acyl fluorides using a Pd(OAc)2/PCy3 system is described. A wide range of 2-arylbenzoyl fluoride derivatives can be used as fluorenone precursors and the reaction proceeds via an intramolecular coupling between aromatic C-H bonds with acyl C-F bonds. The reaction can be applied to the synthesis of indenofluorenedione derivatives and to the construction of other molecules with fivemembered rings.

Heterocyclic Compound

The present invention provide a compound having an orexin receptor antagonistic activity, which is expected to be useful as medicaments such as agents for the prophylaxis or treatment of sleep disorder, depression, anxiety disorder, panic disorder, schizophrenia, drug dependence, Alzheimer's disease and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

Copper-/Silver-Mediated Arylation of C(sp2)-H Bonds with 2-Thiophenecarboxylic Acids

A copper/silver-mediated arylation of (hetero)aryl C-H bonds with 2-thiophenecarboxylic acids has been achieved. The protocol features a broad substrate scope and high functional group tolerance. Preliminary mechanistic studies indicate that a cascade pro