60510-51-2

Basic information

• Product Name: 2-(3-phenyl-1,2,4-oxadiazol-5-yl)benzoic acid
• Synonyms: 2-(3-phenyl-1,2,4-oxadiazol-5-yl)benzoic acid;2-(3-phenyl-1,2,4-oxadiazol-5-yl)benzoic acid(SALTDATA: FREE)
• CAS NO: 60510-51-2
• Molecular Formula: C₁₅H₁₀N₂O₃
• Molecular Weight: 266.25
• Mol File: 60510-51-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 488.338°C at 760 mmHg
• Flash Point: 249.138°C
• Appearance: /
• Density: 1.32g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.62
• CAS DataBase Reference: 2-(3-phenyl-1,2,4-oxadiazol-5-yl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-phenyl-1,2,4-oxadiazol-5-yl)benzoic acid(60510-51-2)
• EPA Substance Registry System: 2-(3-phenyl-1,2,4-oxadiazol-5-yl)benzoic acid(60510-51-2)

Safety Data

• Hazardous Substances Data: 60510-51-2(Hazardous Substances Data)

Usage

Chemical structure

Contains a 1,2,4-oxadiazole ring and a phenyl group, attached to a benzoic acid molecule

Pharmaceutical properties

Potential anti-inflammatory, antipyretic, and analgesic activities

Applications

Materials science and organic synthesis

Future potential

Discovery of new drug candidates or functional materials with further research and development.

InChI:InChI=1/C15H10N2O3/c18-15(19)12-9-5-4-8-11(12)14-16-13(17-20-14)10-6-2-1-3-7-10/h1-9H,(H,18,19)

Upstream product

• 85-44-9 phthalic anhydride 
• 613-92-3 N-hydroxybenzenecarboximidamide 
• 54494-15-4 5-(2-methylphenyl)-3-phenyl-1,2,4-oxadiazole 
• 933-88-0 ortho-toluoyl chloride 
• 100-47-0 benzonitrile 

Relevant articles and documents

Room-temperature synthesis of pharmaceutically important carboxylic acids bearing the 1,2,4-oxadiazole moiety

An efficient and mild one-pot protocol has been developed for the synthesis of 1,2,4-oxadiazoles via the reaction of amidoximes with dicarboxylic acid anhydrides in a NaOH/DMSO medium. The method allows the synthesis of diversely substituted carboxylic acids bearing the 1,2,4-oxadiazole motif, – a popular building block for pharmaceutical research, in moderate to excellent yields. The reaction scope includes aromatic and heteroaromatic amidoximes as well as five-, six- and seven-membered anhydrides. The advantages of this procedure are proven gram-scalability and the use of inexpensive starting materials, which from a process chemistry point of view are essential for future industrial applications.