60419-23-0

Basic information

• Product Name: (R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine
• Synonyms: (R)-(-)-1-(2-PYRROLIDINYLMETHYL)PYRROLIDINE;(R)-(-)-1-(2-PYRROLIDINYLMETHYL)PYRROLIDINE 98%;(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine98%;(R)-1-(Pyrrolidin-2-ylMethyl)pyrrolidine;(R)-1-(2-Pyrrolidinylmethyl)pyrrolidine dihydrochloride;Pyrrolidine, 1-[(2R)-2-pyrrolidinylmethyl]-;(2R)-2-(1-Pyrrolidinylmethyl)pyrrolidine;(R)-2-(Pyrrolidin-1-ylmethyl)pyrrolidine 2HCl
• CAS NO: 60419-23-0
• Molecular Formula: C₉H₁₈N₂
• Molecular Weight: 154.25
• Mol File: 60419-23-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 265.8 °C at 760 mmHg
• Flash Point: 87.8 °C
• Appearance: /
• Density: 0.975 g/cm³
• Vapor Pressure: 0.00898mmHg at 25°C
• Refractive Index: 1.4850 to 1.4890
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 10.91±0.10(Predicted)
• CAS DataBase Reference: (R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine(60419-23-0)
• EPA Substance Registry System: (R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine(60419-23-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 60419-23-0(Hazardous Substances Data)

Usage

General Description

"(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine" is a synthetic compound that belongs to the family of Pyrrolidines. Pyrrolidines are organic compounds that contain a pyrrolidine moiety, which is a five-membered saturated ring with four carbon atoms and one nitrogen atom. This specific chemical, also known as Pyrrolidinium, 1-[(R)-1-(pyrrolidin-1-yl)ethyl]-, is used in various fields of research due to its ability to act as a ligand or catalyst. Its R-(-) configuration indicates that the structure of the molecule is chiral, meaning it cannot be superimposed onto its mirror image, which enriches its potential for various applications in biochemistry or medicinal chemistry.

InChI:InChI=1/C9H18N2/c1-2-7-11(6-1)8-9-4-3-5-10-9/h9-10H,1-8H2/p+2/t9-/m1/s1

Upstream product

• 144243-44-7 tert-butyl (S)-2-(pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate 
• 128510-88-3 tert-butyl (R)-2-(4-methylbenzenesulfonyloxymethyl)pyrrolidine-1-carboxylate 
• 59378-81-3 1-(tert-butoxycarbonyl)prolin-2R-ol 
• 68832-13-3 D-prolinol 
• 147-85-3 L-proline 
• 344-25-2 D-Prolin 
• 144243-44-7 (R)-(+)-1-pyrrolidine 
• 37784-17-1 N-(tert-butoxycarbonyl)-D-proline 
• 1192-63-8 1-pyrrolidinecarbonyl chloride 
• 4042-36-8 D-pyrrolidone-5-carboxylic acid 
• 110958-18-4 (R)-5-[(pyrrolidin-1-yl)carbonyl]pyrrolidin-2-one 
• 144243-45-8 (R)-(+)-1-prolinamidopyrrolidine 

Downstream Products

• 144301-82-6 (R)-(+)-1-<2-(3,4-dichlorophenyl)acetyl>-2-(1-pyrrolidinylmethyl)pyrrolidine 
• 914298-88-7 (R)-(5-chloro-2,4-bis(methoxymethoxy)phenyl)(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)methanone 
• 1401301-06-1 (R)-2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-9-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine 
• 1550175-01-3 4-((5-methyl-4-(4-(trifluoromethoxy)phenyl)pyrimidin-2-yl)amino)-N-(2-methyl-5-((2-(1-pyrrolidinylmethyl)-1-pyrrolidinyl)methyl)phenyl)benzamide 
• 1227075-57-1 (R)-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanone 
• 756520-44-2 (R)-(4-(6-amino-5-hydroxypyridin-3-yl)phenyl)(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)methanone 
• 756520-43-1 (R)-(4-(5-benzyloxy-6-aminopyridin-3-yl)phenyl)(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)methanone 

Relevant articles and documents

Enantioselective Synthesis of 6,6-Disubstituted Pentafulvenes Containing a Chiral Pendant Hydroxy Group

Simple enantioselective synthesis of 6,6-disubstituted pentafulvenes bearing chiral pendant hydroxy groups are attained by cascade reactivity using commercially available proline-based organocatalysts. Condensation of cyclopentadiene with the acetyl function of a 1,2-formylacetophenone, followed by cyclization of a resulting fulvene-stabilized carbanion with the formyl group, generates bicyclic chiral alcohols with initial er values up to 94:6. Exceptional enantio-enrichment of the resultant alcohols results upon crystallization—even near racemic samples spontaneously de-racemize. This enables new families of substituted cyclopentadienes that are both enantiomerically and diastereomerically pure to be rapidly attained.

ENANTIOMERICALLY PURE AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS

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AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS

Aminopyridine and aminopyrazine compounds of formula (1), compositions including these compounds, and methods of their use are provided. Preferred compounds of formula 1 have activity as protein kinase inhibitors, including as inhibitors of c-MET.