6018-89-9

Basic information

• Product Name: Nickel(II) acetate tetrahydrate
• Synonyms: aceticacid,nickel(+2)salt,tetrahydrate;diacetatonickeltetrahydrate;nickeldiacetatetetrahydrate;Tetraaquabis(acetato)nickel(II);NICKEL(OUS) ACETATE TETRAHYDRATE;NICKEL(II) ACETATE-4-HYDRATE;NICKEL(II) ACETATE TETRAHYDRATE;NICKEL ACETATE
• CAS NO: 6018-89-9
• Molecular Formula: 2C₂H₃O₂*4H₂O*Ni
• Molecular Weight: 248.84
• EINECS: 206-761-7
• Product Categories: metal acetate salt;Nickel Salts;Catalysis and Inorganic Chemistry;Chemical Synthesis;Materials Science;Metal and Ceramic Science;Nickel;Salts;nickel , acetate;Imidazoles
• Mol File: 6018-89-9.mol
• Article Data: 2

Chemical Properties

• Melting Point: °Cd ec.)
• Boiling Point: 117.1 °C at 760 mmHg
• Flash Point: 40 °C
• Appearance: White to off-white/Solid
• Density: 1.798 g/mL at 25 °C(lit.)
• Storage Temp.: Inert atmosphere,Room Temperature
• Water Solubility: 182 g/L (20 ºC)
• Sensitive: Hygroscopic
• Stability: Stable.
• Merck: 14,6499
• BRN: 3730764
• CAS DataBase Reference: Nickel(II) acetate tetrahydrate(CAS DataBase Reference)
• NIST Chemistry Reference: Nickel(II) acetate tetrahydrate(6018-89-9)
• EPA Substance Registry System: Nickel(II) acetate tetrahydrate(6018-89-9)

Safety Data

• Hazard Codes: T,Xn,N
• Statements: 45-22-43-40-68-50/53-48/23-42/43-20/22-61-49
• Safety Statements: 53-36/37-45-24-22-61-60
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 3
• RTECS: QR6126000
• TSCA: Yes
• HazardClass: 9
• PackingGroup: III
• Hazardous Substances Data: 6018-89-9(Hazardous Substances Data)

Usage

Description

Nickel(II) acetate tetrahydrate is a chemical compound with the formula Ni(CH3COO)2·4H2O. It is a greenish-blue crystalline solid that is soluble in water and slightly soluble in ethanol. Nickel(II) acetate tetrahydrate is a source of nickel ions and is commonly used as a catalyst, a precursor for the synthesis of various nickel-containing materials, and in the preparation of catalysts for the hydrogenation of fats and oils.

Uses

Used in the Synthesis of Polynuclear-Nickel Polyoxotungstate Cluster Compounds:
Nickel(II) acetate tetrahydrate is used as a precursor in the synthesis of polynuclear-nickel polyoxotungstate cluster compounds. These compounds are ideal for the design of molecular magnets, which have potential applications in data storage, quantum computing, and other advanced technologies.
Used in the Synthesis of Metalloprophyrazines:
Nickel(II) acetate tetrahydrate is used as a reactant in the synthesis of metalloprophyrazines, which are active components of membranes for anion-selective electrodes. These electrodes are used in various analytical and sensing applications, including environmental monitoring, medical diagnostics, and industrial process control.
Used in the Preparation of Catalysts for Hydrogenation of Fats and Oils:
Nickel(II) acetate tetrahydrate is used in the preparation of catalysts for the hydrogenation of fats and oils. This process is important in the food industry for the production of margarine and other hydrogenated oils, which have specific melting points and consistencies.

Preparation

Nickel acetate is prepared by reacting nickel hydroxide or nickel carbonate with dilute acetic acid. The tetrahydrate is crystallized from solution. Ni(OH)2 + 2CH3COOH → (CH3COO)2Ni + 2H2O NiCO3 + 2CH3COOH → (CH3COO)2Ni + CO2 + 2H2O On heating, the solution hydrolyzes depositing nickel hydroxide.

Safety Profile

Confirmed human carcinogen. Poison by ingestion and intraperitoneal routes. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. See also NICKEL(II) ACETATE and NICKEL COMPOUNDS.

Purification Methods

The acetate crystallises from aqueous AcOH as the green tetrahydrate salt. It is soluble in 6 parts of H2O. It forms lower hydrates and should be kept in a well-sealed container. [Hardt & Pohlmann Z Anorg Allgem Chem 343 92 1966, Beilstein 2 IV 120.]

InChI:InChI=1/C2H4O2.Ni.4H2O/c1-2(3)4;;;;;/h1H3,(H,3,4);;4*1H2/q;+2;;;;/p-1

Synthetic route

nickel(II) carbonate (719261-06-0) + water (7732-18-5) + acetic acid (64-19-7) → nickel(II) acetate tetrahydrate (6018-89-9)

Conditions	Yield
In water recrystalization (D2O);

nickel(II) oxide (1313-99-1) + acetic acid (64-19-7) → nickel(II) acetate tetrahydrate (6018-89-9)

Conditions	Yield
In acetic acid
In acetic acid aq. acetic acid;

acetate (71-50-1) + nickel (7440-02-0) → nickel(II) acetate tetrahydrate (6018-89-9)

Conditions	Yield
In water Electrolysis;
In water Electrolysis;

acetic acid (64-19-7) + nickel(II) hydroxide → nickel(II) acetate tetrahydrate (6018-89-9)

Conditions	Yield
In acetic acid aq. acetic acid;

nickel (7440-02-0) + acetic acid (64-19-7) → nickel(II) acetate tetrahydrate (6018-89-9)

Conditions	Yield
With oxygen In acetic acid heating while passing O2 over a suspension of Ni and NiBr2 in 40% acetic acid at 100°C for more than 3.5 h;;
In acetic acid dissolving in concd. acetic acid, heating;;
With O2; Ni bromide In acetic acid aq. acetic acid; heating while passing O2 over a suspension of Ni and NiBr2 in 40% acetic acid at 100°C for more than 3.5 h;;
In acetic acid aq. acetic acid; dissolving in concd. acetic acid, heating;;
In acetic acid dissolving in concd. acetic acid, heating;;

nickel(III) oxide hydrate + nickel (7440-02-0) + acetic acid (64-19-7) → nickel(II) acetate tetrahydrate (6018-89-9)

Conditions	Yield
In acetic acid in autoclave at 120°C;;
In acetic acid aq. acetic acid; in autoclave at 120°C;;
In acetic acid in autoclave at 120°C;;

nickel(III) oxide + nickel (7440-02-0) + acetic acid (64-19-7) → nickel(II) acetate tetrahydrate (6018-89-9)

Conditions	Yield
In acetic acid in autoclave at 120°C;;
In acetic acid aq. acetic acid; in autoclave at 120°C;;
In acetic acid in autoclave at 120°C;;

nickel(II) sulphate + barium(II) acetate (543-80-6) → nickel(II) acetate tetrahydrate (6018-89-9)

Conditions	Yield
In water
In water

Ni(2+)*2CH3CO2(1-)*2B2O(CH3CO2)4=Ni(CH3CO2)2*2B2O(CH3CO2)4 → boric acid (11113-50-1) + nickel(II) acetate tetrahydrate (6018-89-9) + acetic acid (64-19-7)

Conditions	Yield
With water In water
With H2O In water

5,10,15,20-tetraphenyl-21H,23H-porphine (917-23-7) + nickel(II) acetate tetrahydrate (6018-89-9) → 5,10,15,20-tetraphenylporphinatonickel(II) (14172-92-0)

Conditions	Yield
In pyridine other Radiation; porphyrin, metal salt and pyridine were sealed in a glass tube, microwave power of 300 W, heated from room temp. to 180°C, stirred for 15min, cooled to 50°C; vessel was opened, decanted, TLC (silica gel), UV;	100%
In methanol; chloroform tetraphenylporphyrin (300 mg) and Ni(OAc)2*4H2O (1 g) refluxed (16 h) inCHCl3/MeOH (2:1); cooled; solvent removed (vac.); dissolved in CHCl3; chromd. (silica, CHCl3);	99%

Mo(CO)5((C6H5)2PNHCH2CH2NCHC6H4OH) (102942-30-3) + nickel(II) acetate tetrahydrate (6018-89-9) → trans-{Mo(CO)5(Ph2PNHCH2CH2N=CHC6H4-o-O)}2Ni

Conditions	Yield
In tetrahydrofuran A mixt. of Ni(OAc)2*4H2O and Mo(CO)5(Ph2PNHCH2CH2NCHC6H4OH) in THF was stirred under Ar at ambient temp. for 42 h.; The mixt. was filtered and then the filtrate evapd. to dryness to yield {Mo(CO)5(Ph2PNHCH2CH2NCHC6H4O)}2Ni.;	100%

ammonium hexafluorophosphate + nickel(II) acetate tetrahydrate (6018-89-9) + 2,6-bis<2'-(4'-methylthio)-6'-(2''-pyridinyl)pyridinyl>pyridine (78570-49-7) → {Ni2((C5H4N)2(C5H2(CH3S)N)2C5H3N)2CH3COO}(3+)*3PF6(1-)*H2O={Ni2((C5H4N)2(C5H2(CH3S)N)2C5H3N)2CH3COO}{PF6}3*H2O

Conditions	Yield
In methanol addn of 4.17E-4 mol quinquepyridine to a soln. of 4.17E-4 mol Ni(OOCCH3)2*4H2O in methanol; stirring for 3 h at room temperature; treating with a satd. methanolic soln. of NH4PF6; filtration;; washing with methanol; recrystallization from nitromethane/diethyl ether; elem. anal.;;	100%

(Z)-5,5'-vinylenebis(2,3,7,8,12,13,17,18-octaethylporphyrin)-platinum(II) + nickel(II) acetate tetrahydrate (6018-89-9) → (Z)-5,5'-vinylenebis(2,3,7,8,12,13,17,18-octaethylporphyrin)-nickel(II)-platinum(II)

Conditions	Yield
In methanol; chloroform mixt. of Pt complex and Ni salt in CHCl3/MeOH (5:3) refluxed for 15 h; poured into H2O, extd. with CHCl3, washed with brine, dried and evapd.,column chromy. on SiO2; recrystn. from CHCl3-MeOH; elem. anal.;	100%

meso-tetraphenyl-2-oxa-3-oxoporphyrin + nickel(II) acetate tetrahydrate (6018-89-9) → meso-tetraphenyl-2-oxa-3-oxoporphyrinatonickel(II) (922142-13-0)

Conditions	Yield
In pyridine other Radiation; 3 equiv of Ni-salt, porphyrin, pyridine were sealed in glass tube, stirred under microwave power of 300 W, hetaed from room temp. to 180°C for 15 min; cooled to 50°C, removed from the microwave cavity, opened, decanted, preparative chromy. (petroleum ether-CH2Cl2);	100%

5-(4'-iodophenyl)-10,15,20-tris(3'',5''-di-tert-butylphenyl)porphin + nickel(II) acetate tetrahydrate (6018-89-9) → [5(4'-iodophenyl)tetrakis-10,15,20-tris(3'',5''-di-tert-butylphenyl)porphyrinato]nickel(II) (281211-15-2)

Conditions	Yield
In N,N-dimethyl-formamide refluxed for 40 min; cooled, ether added, washed (water), dried (Na2SO4), filtered,solvent removed, chromy. (silica, dichloromethane/light petroleum), solvent removed, recrystd. (CH2Cl2/CH3OH); elem. anal.;	100%

nickel(II) acetate tetrahydrate (6018-89-9) + 1,4-bis[3-(4-chlorophenyl)-4,6-dimethoxyindol-7-ylmethyleneamino]benzene (362590-31-6) → (1,4-bis[3-(4-chlorophenyl)-4,6-dimethoxyindol-7-ylmethyleneamino]benzenato(2-))nickel(II) (362590-60-1)

Conditions	Yield
With Et3N In acetonitrile ligand was dissolved at reflux, anhyd. Et3N and the metal salt were added, mixt. was heated at reflux for 8 h; mixt. was filtered warm, ppt. was washed with MeCN followed by anhyd. Et2O, dried in air;	100%

nickel(II) acetate tetrahydrate (6018-89-9) + 2-Amino-3-nitro-5,10,15,20-tetraphenylporphyrin → nickel(II) 2-amino-3-nitro-5,10,15,20-tetraphenylporphyrin

Conditions	Yield
With acetic acid In chloroform	100%

disodium 3-(2-methoxyethoxy)salicylaldehyde-5-sulfonate + nickel(II) acetate tetrahydrate (6018-89-9) + 1,2-diamino-benzene (95-54-5) → C26H24N2NiO12S2(2-)*2Na(1+)

Conditions	Yield
In methanol for 13h; Reflux;	100%

C25H20O5 + nickel(II) acetate tetrahydrate (6018-89-9) → C150H102Ni9O30*2H2O

Conditions	Yield
With sodium hydroxide In ethanol; water at 20 - 110℃; for 72h; pH=7; Autoclave; High pressure;	100%

C88H110N4O12 + nickel(II) acetate tetrahydrate (6018-89-9) → C88H108N4NiO12

Conditions	Yield
In methanol; chloroform at 60℃; for 264h; Inert atmosphere;	100%

C74H68N4 + nickel(II) acetate tetrahydrate (6018-89-9) → C74H66N4Ni

Conditions	Yield
In toluene at 120℃; for 5h; Inert atmosphere;	100%

methyl-2-(N-[2-(2'-hydroxyphenyl)methylidynenitrilo]ethyl)amino-1-cyclopentenedithiocarboxylate + nickel(II) acetate tetrahydrate (6018-89-9) → nickel(II) methyl-2-(N-(2-(2'-phenolate)methylidynenitrilo)ethyl)aminato(1-)-1-cyclopentenedithiocarboxylate

Conditions	Yield
In methanol; chloroform addn. of Ni-salt soln. (in MeOH) to equimolar amt. of ligand soln. (in CHCl3/MeOH=2:1), stirring for 15 min; pptn. on standing (room temp., 24 h), recrystn. (MeCN/MeOH=1:1); elem. anal.;	99.8%
In methanol; chloroform stoichiometric amts., ratio CH3OH:CHCl3 1:1, pptn. in several h; recrystn. (CH3CN); elem. anal.;

N-(2-hydroxyl-3,5-di-tert-butylbenzaldehyde)-1-amino-2-benzeneimine (308086-87-5) + nickel(II) acetate tetrahydrate (6018-89-9) + 2-hydroxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde (620595-36-0) → N-(3,5-di-tert-butylsalicylidene)-N′-(5-(4,4,5,5,-tetramethyl-1,3,2-dioxa-borolan-2-yl)salicylidene)phenylenediaminatonickel(II)

Conditions	Yield
Stage #1: N-(2-hydroxyl-3,5-di-tert-butylbenzaldehyde)-1-amino-2-benzeneimine; nickel(II) acetate tetrahydrate With triethylamine In methanol for 0.0833333h; Stage #2: 2-hydroxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde In tetrahydrofuran	99.8%

2-bromo-5,10,15,20-tetraphenylporphyrin + nickel(II) acetate tetrahydrate (6018-89-9) → (2-bromo-5,10,15,20-tetraphenylporphyrinato)nickel(II) (52588-61-1)

Conditions	Yield
In methanol; chloroform β-tetraphenylporphyrin (240 mg) and Ni(OAc)2*4H2O (800 mg) refluxed(16 h) in CHCl3/MeOH (2:1); cooled; solvent removed (vac.); dissolved in CHCl3; chromd. (silica, CHCl3);	99%

malonaldehydebis(dimethylacetal) (102-52-3) + nickel(II) acetate tetrahydrate (6018-89-9) + 4,5-dimethyl-1,2-phenylenediamine (3171-45-7) → {7,16-dihydro-2,3,11,12-tetramethyldibenzo{b,i}{1,4,8,11}tetraazacyclotetradecinato-N5,N9,N14,N18}nickel(II) (57574-24-0)

Conditions	Yield
In water; N,N-dimethyl-formamide reflux for 10 h; filtn., chromy.; elem. anal.;;	99%

2N((CH2)3CH3)4(1+)*Mo2O5(O2C6H2(NCHC6H3(OC2H5)OH)2)2(2-)=[N((CH2)3CH3)4]2[Mo2O5(O2C6H2(NCHC6H3(OC2H5)OH)2)2] + nickel(II) acetate tetrahydrate (6018-89-9) → 2N((CH2)3CH3)4(1+)*Mo2O5(O2C6H2(NCHC6H3(OC2H5)O)2Ni)2(2-)=[N((CH2)3CH3)4]2[Mo2O5(O2C6H2(NCHC6H3(OC2H5)O)2Ni)2]

Conditions	Yield
In methanol; acetone byproducts: H2O; inert atmosphere; dropwise addn. of metal acetate (in MeOH) to 0.5 equiv. Mn-complex (in Me2CO), stirring for 1 h; solvent removal (vac.), dissoln. in THF/CH2Cl2=10:1, pptn. on Et2O addn., standing overnight;	99%

2N((CH2)3CH3)4(1+)*Mo2O5(O2C6H2(NCHC6H2(C(CH3)3)2OH)2)2(2-)=[N((CH2)3CH3)4]2[Mo2O5(O2C6H2(NCHC6H2(C(CH3)3)2OH)2)2] + nickel(II) acetate tetrahydrate (6018-89-9) → 2N((CH2)3CH3)4(1+)*Mo2O5(O2C6H2(NCHC6H2(C4H9)2O)2Ni)2(2-)=[N((CH2)3CH3)4]2[Mo2O5(O2C6H2(NCHC6H2(C4H9)2O)2Ni)2]

Conditions	Yield
In methanol; acetone byproducts: H2O; inert atmosphere; dropwise addn. of metal acetate (in MeOH) to 0.5 equiv. Mn-complex (in Me2CO), stirring for 1 h; solvent removal (vac.), dissoln. in PhMe, pptn. on addn. of hexanes, standing overnight;	99%

4-(trans-2-(5,10,15,20-tetraphenylporphyrin-2-yl)ethen-1-yl)nitrobenzene + nickel(II) acetate tetrahydrate (6018-89-9) → Ni(4-(trans-2-(5,10,15,20-tetraphenylporphinato-2-yl)ethen-1-yl)nitrobenzene)

Conditions	Yield
In methanol; chloroform; water addn. of excess Ni-salt (in MeOH/water=5:1 v/v) to refluxing soln. of porphyrin in CHCl3, refluxing for 16 h; washing (water), drying (MgSO4), solvent removal (reduced pressure), recrystn. (CH2Cl2/MeOH);	99%

1,1'-di(2-picolyl)-3,3'-methylenediimidazolium dibromide + nickel(II) acetate tetrahydrate (6018-89-9) → (1,1'-di(2-picolyl)-3,3'-methylenediimidazolin-2,2'-diylidene)nickel(II) dibromide

Conditions	Yield
In dimethyl sulfoxide (Schlenk, dry N2) a soln. of bromide and Ni-compound in DMSO was heated at 50°C for 3 h, then at 110°C for 2 h; the solvent was removed under vac., the residue was washed with THF, filtered, dried under vac.; elem. anal.;	99%

5,10,15,20-tetrakis(3,5-di-tert-butylphenyl)bisquinoxalino[2,3-b':7,8-b'']porphyrin + nickel(II) acetate tetrahydrate (6018-89-9) → [5,10,15,20-tetrakis(3,5-di-tert-butylphenyl)bisquinoxalino[2,3-b':7,8-b'']porphyrinato]nickel(II) (1009836-28-5)

Conditions	Yield
In acetic acid; toluene porphyrin and metal salt (1:4) dissolved in toluene and glacial acetic acid, refluxed for 1 min; treated with CH2Cl2, org. phase separated, washed (H2O, Na2CO3 soln., H2O), dried (Na2SO4), filtered, evapd., chromy.(silica gel - light petroleun 1:3), collected, evapd., elem. anal.;	99%

dimethyl 2,2'-dihydroxy-1,1'-binaphthalene-3,3'-dicarboxylate (47644-69-9, 69678-00-8, 18531-91-4) + nickel(II) acetate tetrahydrate (6018-89-9) → [Ni2(H2O)4(2,2'-dihydroxy-3,3'-di(carboxymethyl)-1,1'-binaphthyl(-2H))2]*2H2O

Conditions	Yield
With sodium acetate In methanol; pentan-1-ol heating of MeOH soln. of Ni(CH3COO)2*4H2O on water bath; addn. of 2,2'-dihydroxy-2,2'-di(carboxymethyl)-1,1'-binaphthyl in pentanol; adjusting pH to 5.0 by addn. of NaCH3COO; reflux on water bath for 3 h; pptn. upon heating, filtration, washing with EtOH; drying in desiccator over silica gel; elem. anal.;	99%

5,10,15,20-tetrakis(4-methylphenyl)porphyrin + (C5H3N(NCHC6H2(O)(tBu)2)2)Zn (1020152-19-5) + nickel(II) acetate tetrahydrate (6018-89-9) → [(tetra(p-tolyl)porphyrinato)Zn(NC5H3(NCHC6H2(C(CH3)3)2O)2)Ni] (1143464-63-4)

Conditions	Yield
In tetrahydrofuran stirred at room temp. for 18 h; concd. (vac.), triturated with n-hexane;	99%

[Zn2((C6H3(NCHC6H2(O)(OCH3)CH2CHCH2)NCHC6H2(C(CH3)3)2O)2)] (1289376-52-8) + nickel(II) acetate tetrahydrate (6018-89-9) → [Ni2((C6H3(NCHC6H2(O)(OCH3)CH2CHCH2)NCHC6H2(C(CH3)3)2O)2)] (1289376-53-9)

Conditions	Yield
In methanol; dichloromethane a MeOH soln. of Ni salt added to a suspn. of Zn complex in CH2Cl2; concd., the residue suspended in MeOH, filtered off, washed (MeOH), dried in air;	99%

15,15-difluoro-1,4,7,10,13-pentaazacyclohexadecane-14,16-dione (854139-47-2) + nickel(II) acetate tetrahydrate (6018-89-9) → [Ni(OAc)2(15,15-difluoro-1,4,7,10,13-pentaazacyclohexadecane-14,16-dione)] (1356598-32-7)

Conditions	Yield
In ethanol N2; ligand and Co compd. (1:1 molar ratio) refluxed for 3 h; filtered, evapd., elem. anal.;	99%

C102H150N8O6S6 (1443453-72-2) + nickel(II) acetate tetrahydrate (6018-89-9) → C104H152N8NiO6S4

Conditions	Yield
In N,N-dimethyl-formamide at 155℃; for 3h; Inert atmosphere;	99%

5,15-dibromo-10,20-dipentylporphyrin + nickel(II) acetate tetrahydrate (6018-89-9) → Ni [5,15-dipentyl-10,20-dibromoporphyrin]

Conditions	Yield
In N,N-dimethyl-formamide at 140℃; for 5h;	99%

Upstream product

• 71-50-1 acetate 
• 7440-02-0 nickel 
• 64-19-7 acetic acid 
• 543-80-6 barium(II) acetate 
• 1313-99-1 nickel(II) oxide 
• 719261-06-0 nickel(II) carbonate 
• 7732-18-5 water 

Downstream Products

• 1313-99-1 nickel(II) oxide 
• 554-13-2 lithium carbonate 
• 58676-54-3 bis(1,1-diethyl-3-benzoylthioureato) nickel(II) 

Relevant articles and documents

Crystal structure and low-temperature methyl-group dynamics of cobalt and nickel acetates

The crystal structures of cobalt and nickel acetate tetrahydrate have been determined at room-temperature and liquid-helium temperature by neutron powder diffraction of the fully deuterated salts. Molecular mechanics and ab initio methods based on these s