59721-16-3

Basic information

• Product Name: 4-Hydroxy Benzeneacetic Acid 2-(DiMethylaMino)-2-oxoethyl Ester
• Synonyms: 4-Hydroxy Benzeneacetic Acid 2-(DiMethylaMino)-2-oxoethyl Ester;2-(diMethylaMino)-2-oxoethyl (4-hydroxyphenyl)acetate;2-(diMethylaMino)-2-oxoethyl 2-(4-hydroxyphenyl)acetate;4-Hydroxybenzeneacetic acid 2-(dimethylamino)-2-oxoethyl ester (Camostat mesilate)
• CAS NO: 59721-16-3
• Molecular Formula: C₁₂H₁₅NO₄
• Molecular Weight: 237
• Product Categories: Aromatics;Intermediates;Metabolites & Impurities
• Mol File: 59721-16-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 410.4±30.0 °C(Predicted)
• Appearance: /
• Density: 1.219±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 9.79±0.15(Predicted)
• CAS DataBase Reference: 4-Hydroxy Benzeneacetic Acid 2-(DiMethylaMino)-2-oxoethyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hydroxy Benzeneacetic Acid 2-(DiMethylaMino)-2-oxoethyl Ester(59721-16-3)
• EPA Substance Registry System: 4-Hydroxy Benzeneacetic Acid 2-(DiMethylaMino)-2-oxoethyl Ester(59721-16-3)

Safety Data

• Hazardous Substances Data: 59721-16-3(Hazardous Substances Data)

Usage

Uses

Impurity of Camostat (C150300).

Upstream product

• 156-38-7 4-hydroxyphenylacetate 
• 5468-77-9 2-bromo-N,N-dimethylethanamide 
• 2675-89-0 2-chloro-N,N-dimethylacetamide 

Downstream Products

• 59721-28-7 camostat 
• 59721-29-8 camostat mesylate 
• 70884-81-0 7-Nitro-1,2,3,4-tetrahydro-naphthalene-1-carboxylic acid 4-dimethylcarbamoylmethoxycarbonylmethyl-phenyl ester 
• 70884-55-8 5-Nitro-1,2,3,4-tetrahydro-naphthalene-1-carboxylic acid 4-dimethylcarbamoylmethoxycarbonylmethyl-phenyl ester 

Relevant articles and documents

A 2 - (dimethylamino) - 2-oxo-ethyl-2 - (4-hydroxy phenyl) acetic acid methyl ester preparation method

The invention discloses a preparation method of 2-(dimethylamino)-2-oxoethyl-2-(4-hydroxyphenyl) methyl acetate, which comprises the steps of allowing dimethylamine to react with chloroacetyl chloride to generate N,N-dimethyl-2-chloroacetamide, allowing N,N-dimethyl-2-chloroacetamide to react with p-hydoxyphenylactic acid to generate a crude product of 2-(dimethylamino)-2-oxoethyl-2-(4-hydroxyphenyl) methyl acetate, and refining the crude product to form a fine product of 2-(dimethylamino)-2-oxoethyl-2-(4-hydroxyphenyl) methyl acetate. 2-(dimethylamino)-2-oxoethyl-2-(4-hydroxyphenyl) methyl acetate prepared by the method is high in quality and purity, and the preparation method is simple, low in energy consumption and low in cost.

A methanesulfonic acid the card not takes charge of he process for the preparation of intermediates

The invention discloses a preparation method of methanesulfonic acid camostat. The method comprises the following steps: dimethylamine reacts with chloroacetyl chloride to obtain 3-pyrrolidone hydrochloride, a 3-pyrrolidone hydrochloride crude product is added with hydroxyphenylacetic acid and triethylamine to obtain methanesulfonic acid camostat, and a methanesulfonic acid camostat product is prepared from the obtained methanesulfonic acid camostat. The methanesulfonic acid camostat prepared by adopting the method is good in quality, high in yield, less in energy consumption and low in cost, and meanwhile, the preparation method is simple.