596103-11-6

Basic information

• Product Name: Adenosine, 2-chloro-N-[(3-iodophenyl)methyl]-2',3'-O-(1-methylethylidene)-4'-thio-, 5'-benzoate
• CAS NO: 596103-11-6
• Molecular Formula: C27H25ClIN5O4S
• Molecular Weight: 677.95
• Mol File: 596103-11-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Adenosine, 2-chloro-N-[(3-iodophenyl)methyl]-2',3'-O-(1-methylethylidene)-4'-thio-, 5'-benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Adenosine, 2-chloro-N-[(3-iodophenyl)methyl]-2',3'-O-(1-methylethylidene)-4'-thio-, 5'-benzoate(596103-11-6)
• EPA Substance Registry System: Adenosine, 2-chloro-N-[(3-iodophenyl)methyl]-2',3'-O-(1-methylethylidene)-4'-thio-, 5'-benzoate(596103-11-6)

Safety Data

• Hazardous Substances Data: 596103-11-6(Hazardous Substances Data)

Upstream product

• 3718-88-5 3-iodobenzylamine hydrochloride 
• 596103-10-5 benzoic acid (3aS,4R,6R,6aR)-6-(2,6-dichloro-purin-9-yl)-2,2-dimethyl-tetrahydro-thieno[3,4-d][1,3]dioxol-4-ylmethyl ester 
• 696-40-2 3-iodobenzylamine 
• 117859-45-7 methanesulfonic acid (S)-((4R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-((4S,5S)-5-methanesulfonyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-methyl ester 
• 6322-07-2 D-gulono-1,4-lactone 
• 596103-09-2 benzoic acid (3aS,4R,6RS,6aR)-6-acetoxy-2,2-dimethyl-tetrahydro-thieno[3,4-d][1,3]dioxol-4-ylmethyl ester 
• 683275-15-2 benzoic acid (3aS,4R,5R,6aR)-(3aS,4R,5S,6aR)-2,2-dimethyl-5-oxotetrahydro-5λ4-thieno[3,4-d][1,3]dioxol-4-yl methyl ester 
• 596103-07-0 benzoic acid (3aS,4R,6aR)-2,2-dimethyl-tetrahydro-thieno[3,4-d][1,3]dioxol-4-ylmethyl ester 
• 596103-04-7 (3aS,4R,6aR)-4-((4R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyltetrahydrothieno[3,4-d][1,3]dioxolane 
• 596103-05-8 (1R)-1-((3aS,4R,6aR)-2,2-dimethyl-tetrahydro-thieno[3,4-d][1,3]dioxol-4-yl)-ethane-1,2-diol 
• 596103-06-9 ((3aS,4R,6aR)-2,2- dimethyltetrahydrothieno[3,4-d][1,3]dioxol-4-yl)methanol 
• 666750-24-9 (3aS,4S,6aR)-2,2-dimethyltetrahydrothieno[3,4- d][1,3]dioxole-4-carbaldehyde 
• 67642-42-6 2,3,5,6-di-O-isopropylidene-D-gulono-1,4-lactone 
• 3969-61-7 2,3:5,6-di-O-isopropylidene-D-gulitol 

Downstream Products

• 666750-34-1 benzoic acid (2R,3S,4R,5R)-5-[2-chloro-6-(3-iodobenzylamino)purin-9-yl]-3,4-dihydroxy-tetrahydro-thiophen-2-yl methyl ester 
• 596103-01-4 (2S,3S,4R,5R)-5-[2-chloro-6-(3-iodobenzylamino)-purin-9-yl]-3,4-dihydroxy-tetrahydro-thiophene-2-carboxylic acid methylamide 
• 596103-14-9 {(2R,3S,4R,5R)-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-[2-chloro-6-(3-iodobenzylamino)-purin-9-yl]-tetrahydro-thiophen-2-yl}-methanol 
• 666830-47-3 (2S,3S,4R,5R)-3,4-bis(tert-butyldimethylsilanyloxy)-5-(2-chloro-6-(3-iodobenzylamino)purin-9-yl)-tetrahydro-thiophene-2-carboxylic acid methylamide 
• 871913-94-9 (2S,3S,4R,5R)-3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-5-[2-chloro-6-(3-iodo-benzylamino)-purin-9-yl]-tetrahydro-thiophene-2-carboxylic acid 

Relevant articles and documents

Structure-activity relationships of 2-chloro-N6-substituted-4′-thioadenosine-5′-N,N-dialkyluronamides as human A3 adenosine receptor antagonists

On the basis of potent and selective A3 adenosine receptor (AR) antagonist, 2-chloro-N6-(3-iodobenzyl)-4′-thioadenosine-5′-N,N-dimethyluronamide, structure-activity relationships were studied for a series of 5′-N,N-dialkyluronamide d

Structure-activity relationships of 2-chloro-N6-substituted- 4′-thioadenosine-5′-uronamides as highly potent and selective agonists at the human A3 adenosine receptor

We have established structure-activity relationships of novel 4′-thionucleoside analogues as the A3 adenosine receptor (AR) agonists. Binding affinity, selectivity toward other AR subtypes, and efficacy in inhibition of adenylate cyclase were studied. Fro

Purine nucleosides

Disclosed are purine nucleoside compounds that are selective to A3 adenosine receptors and are useful for the treatment of cancer and inflammatory diseases. The compounds are shown by the following general formula (I), including isomers thereof: wherein X is sulfur or oxygen; R1 is hydrogen, alkyl, benzyl, halobenzyl, or phenylalkyl; R2 is hydrogen, halogen, alkoxy, alkenyl, alkynyl, alkylthio, or thio; R3 and R3′ are hydrogen, hydroxyalkyl, alkoxycarbonyl, or alkylaminocabonyl, whereas R3 and R3′ do not have identical substituents simultaneously; and R4 is hydrogen or alkyl. Also disclosed are a pharmaceutical composition comprising a compound of formula (I), an isomer, or its pharmacologically acceptable salt as an active ingredient and a method for preventing or treating various diseases, state, or condition, including asthma, inflammation, cerebral ischemia, heart diseases, and cancer.