5959-52-4Relevant articles and documents
Synthesis of self-orienting triptycene adsorbates for STM investigations
Wolpaw, Adam J.,Aizer, Ayal A.,Zimmt, Matthew B.
, p. 7613 - 7615 (2003)
The syntheses of three C2 symmetric triptycenes containing two pendant groups are described. The pendant groups are designed to promote oriented adsorption to graphite or gold electrodes such that the unfunctionalized aryl group extends perpendicular to the surface. Initial STM studies are consistent with oriented adsorption on graphite.
2, 3, 6, 7 -pentycene tetracarboxylic dianhydride compound and synthesis method thereof
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Paragraph 0140-0144; 0209-0213, (2020/06/27)
The invention discloses a 2,3,6,7-pentaptycene tetracarboxylic dianhydride compound and a synthetic method thereof. The method comprises three stages. In the first stage, 2,3,6,7-tetramethyl-9,10-p-(2,3-anthryl)anthracene is synthesized; in the second stage, 2,3,6,7-pentaptycene tetracarboxylic acid is synthesized; and in the third stage, 2,3,6,7-pentaptycene tetracarboxylic dianhydride is synthesized. The method is cheap and available in raw materials and high in yield, the purity of products is high, and pentaptycene dianhydride can be efficiently synthesized at low cost. Compared with a series of new polyimide macromolecular materials polymerized from a diamine monomer in the prior art, the compound has great potential application value in the fields of membrane separation materials, dielectric materials and molecular interlocking functional materials.
A 3 - amino -2 - naphthalene armor acid compound preparation process (by machine translation)
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, (2019/06/27)
The invention discloses a 3 - amino - 2 - naphthalene armor acid compound preparation process, characterized in that in the phthaldialdehyde in three is made [...] condensed under the action of the 2, 3 - naphthalene carboxylic acid dimethyl ester; the alkaline hydrolysis is under the condition of 2, 3 - naphthalene carboxylic acid mono methyl ester; then through the DPPA reaction will be carboxyl group into amino, to obtain 3 - tert-butoxy-carboxamide yl - 2 - naphthalene carboxylic acid methyl ester; finally ester, and further takes off uncle butoxycarbonyl, to obtain 3 - amino - 2 - naphthoic acid. The method of mild reaction conditions, suitable for different substrate, without the need to use high temperature autoclave equipment, reduce the safety risk in the production process, to reduce the equipment investment, energy consumption can be reduced, which is suitable for large-scale production. (by machine translation)
Synthesizing method of 9,10-o-naphthyl anthracene-2,3,6,7-tetraformic anhydride
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Paragraph 0055; 0056; 0057, (2018/10/19)
The invention discloses a synthesizing method of 9,10-o-naphthyl anthracene-2,3,6,7-tetraformic anhydride. The method specifically includes the following steps of firstly, preparing 2,3,6,7-tetramethyl-9,10-o-naphthyl anthracene; secondly, synthesizing 9,10-o-naphthyl anthracene-2,3,6,7-tetraformic acid through 2,3,6,7-tetramethyl-9,10-o-naphthyl anthracene; thirdly, synthesizing 9,10-o-naphthyl anthracene-2,3,6,7-tetraformic anhydride through 9,10-o-naphthyl anthracene-2,3,6,7-tetraformic acid. High-value 9,10-o-naphthyl anthracene-2,3,6,7-tetraformic acid is obtained through two different methods, loss is small, the yield and purity are both improved, and mass production is easy.
Synthesis and biological evaluation of a novel acronycine/duocarmycin hybrid natural product
Tietze, Lutz F.,Heins, Arne,Reiner, Johannes R.,Duefert, Svenia-C.,Schuberth, Ingrid
, p. 425 - 433 (2013/08/23)
The design of novel natural product hybrids consisting of parts of two or more bioactive compounds may allow an access to new drugs. Here we describe the synthesis of 3, a hybrid of the cytotoxic acronycine (2) and seco-duocarmycin (seco-1), which was prepared Via a selective bromination of 7 followed by the introduction of an alkyne moiety, which was further manipulated to give the epoxide 12. Cyclisation and chlorination of the formed primary hydroxy group yielded 3, which in situ would give the desired hybrid 4. The in-vitro-cytotoxicity test revealed a slightly higher bioactivity of the hybrid 3 compared to acronycine (2).
PEPTIDES AND PEPTIDOMIMETIC COMPOUNDS, THE MANUFACTURING THEREOF AS WELL AS THEIR USE FOR PREPARING A THERAPEUTICALLY AND/OR PREVENTIVELY ACTIVE PHARMACEUTICAL COMPOSITION
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, (2010/04/25)
Peptides, peptidomimetics and derivatives thereof of the general formula I: H2N-GHRPX1-β-X4X5X6X7X8X9X10-X11 (I), in which X1-X10 denote one of the 20 genetically coded amino acids, wherein X8, X9 and X10 may also denote a single chemical bond;X11 denotes OR1 in which R1 equals hydrogen or (C1-C10) alkyl NR2R3 with R2 and R3 are equal or different and denote hydrogen, (C1-C10) alkyl, or a residue —W-PEG5-60K, in which the PEG residue is attached via a suitable spacer W to the N-atom, ora residue NH—Y-Z-PEG5-60K, in whichY denotes a chemical bond or a genetically coded amino acids from the group S, C, K or R andZ denotes a spacer, via which a polyethylene glycol (PEG)-residue can be attached, and their physiologically acceptable salts, andβ denotes an amino acid, or a peptidomimetic element, which induces a bend or turn in the peptide backbone.
Composition of matter having bioactive properties
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, (2008/06/13)
Particles of coordinated complex comprising a basic, hydrous polymer and a capacitance adding compound, as well as methods for their production, are described. These complexes exhibit a high degree of bioactivity making them suitable for a broad range of applications through their incorporation into conventional vehicles benefiting from antimicrobial and similar properties.
Synthesis and Properties of Ligands Based on Benzoquinoline
Taffarel, Emmanuelle,Chirayil, Sarah,Thummel, Randolph P.
, p. 823 - 828 (2007/10/02)
The preparation of 3-amino-2-naphthaldehyde is described.Ammonolysis of 3-hydroxy-2-naphthoic acid affords the corresponding amino acid which can be esterified and then reduced with LAH.Protection of the amino group, MnO2 oxidation of the primary alcohol to an aldehyde, and deprotection gave the amino aldehyde which is an excellent Friedlaender synthon for benzoquinolines.Dimethylene-bridged analogues of 2,2'-bipyridine and 2,2';6,2''-terpyridine were prepared as well as orthocyclophanes derived from tetracyclo4,11.05,9>undecane-2,7-dione (TCU-2,7-dione).The absorption and emission spectra of these species are consistent with the parent benzoquinoline where bathochromic shifts result from increased delocalization.The TCU derivative evidences exciplex formation so that its benzoquinoline emission is almost completely quenched and an exciplex emission appears at 525 nm.Electrochemical analysis indicates that both reduction and UV absorption involve the same ?* orbital.
Potential Antitumor Agents. 61. Structure-Activity Relationships for in Vivo Colon 38 Activity among Disubstituted 9-Oxo-9H-xanthene-4-acetic Acids
Rewcastle, Gordon W.,Atwell, Graham J.,Zhuang, Li,Baguley, Bruce C.,Denny, William A.
, p. 217 - 222 (2007/10/02)
Analogues of 9-oxo-9H-xanthene-4-acetic acid (XAA) bearing small, lipophilic 5-substituents are among the most dose-potent compounds yet reported with the capability of causing hemorrhagic necrosis of implanted colon 38 tumors in mice.To further extend structure-activity relationships among this class of compound, a series of XAA derivatives bearing two small lipophilic groups at various positions have been prepared and evaluated.The 5,6-disubstituted compounds in particular show consistently high levels of both dose potency and activity, suggesting this is the optimal configuration among substituted 9-oxo-9H-xanthene-4-acetic acids.The 5,6-dimethyl and 5-methyl-6-methoxy are the most effective analogues, showing in vivo colon 38 activity comparable to that of FAA at 10-15-fold lower doses and superior activity to FAA at the respective optimal doses, and the former has been selected for detailed evaluation.
