5909-26-2

Basic information

• Product Name: 2,4-Bis(methylthio)pyrimidine
• Synonyms: 2,4-Bis(methylthio)pyrimidine
• CAS NO: 5909-26-2
• Molecular Formula: C₆H₈N₂S₂
• Molecular Weight: 172.27
• Mol File: 5909-26-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 139-140 °C(Press: 6 Torr)
• Appearance: /
• Density: 1.26±0.1 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 1.83±0.20(Predicted)
• CAS DataBase Reference: 2,4-Bis(methylthio)pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Bis(methylthio)pyrimidine(5909-26-2)
• EPA Substance Registry System: 2,4-Bis(methylthio)pyrimidine(5909-26-2)

Safety Data

• Hazardous Substances Data: 5909-26-2(Hazardous Substances Data)

Usage

Description

2,4-Bis(methylthio)pyrimidine is a chemical compound that features a pyrimidine ring with two methylthio (-SCH3) groups attached at the 2 and 4 positions. This unique structure endows it with a range of biological properties and makes it a versatile intermediate in the synthesis of various compounds.

Uses

Used in Pharmaceutical Industry:
2,4-Bis(methylthio)pyrimidine is used as a key intermediate in the synthesis of pharmaceuticals for its ability to be incorporated into the molecular structures of potential drugs. Its presence in drug molecules can contribute to desired therapeutic effects and properties.
Used in Agrochemical Industry:
In the agrochemical sector, 2,4-Bis(methylthio)pyrimidine is utilized as an intermediate in the development of herbicides and fungicides. Its chemical properties allow it to be a component in the formulation of effective crop protection products.
Used in Biochemical Research:
2,4-Bis(methylthio)pyrimidine is employed as a research tool in biochemistry and medicinal chemistry due to its inhibitory activity against certain enzymes. This makes it valuable for studying enzyme functions and developing enzyme-targeted therapies.
Used in Medicinal Chemistry:
2,4-Bis(methylthio)pyrimidine serves as a building block in medicinal chemistry, where it can be used to design and synthesize new molecules with potential medicinal applications. Its unique structure allows for the exploration of various chemical modifications to enhance pharmacological properties.

Upstream product

• 2001-93-6 2,4-dithiouracil 
• 77-78-1 dimethyl sulfate 
• 512-56-1 trimethyl phosphite 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 2001-93-6 2,4-dimercaptopyrimidine 
• 49844-90-8 4-Chloro-2-methylthiopyrimidine 
• 3934-20-1 2,6-Dichloropyrimidine 
• 5188-07-8 sodium thiomethoxide 

Downstream Products

• 6308-41-4 4-methyl-2,6-bis-methylsulfanyl-pyrimidine 
• 116137-69-0 2,4-Bis-methylsulfanyl-6-phenyl-pyrimidine 
• 116137-70-3 4-(2-Methoxy-phenyl)-2,6-bis-methylsulfanyl-pyrimidine 
• 112380-45-7 2-methylsulfanyl-6-phenyl-5,6-dihydro-3H-pyrimidin-4-one 
• 1080662-19-6 2,4-bis(methylthio-6-(3-trifluoromethylphenyl))pyrimidine 
• 1080662-18-5 4-(2,6-bis(methylthio)pyrimidin-4-yl)-benzoic acid ethyl ester 

Relevant articles and documents

Regio- and chemoselective magnesiation of protected uracils and thiouracils using TMPMgCl?LiCl and TMP2Mg?2LiCl

Two successive regio- and chemoselective magnesiations using TMPMgCl?LiCl and TMP2Mg?2LiCl enable the full functionalization of protected uracils and thiouracils in good to excellent yields. This journal is

Methylathion of Heterocyclic Compounds Containing NH, SH and/or OH Groups by Means of N,N-Dimethylformamide Dimethyl Acetal

Methylations of heterocyclic systems, such as benzimidazole, naphthimidazole, imidazopyridine, purine, pyridine, pyrimidine, pyridazine and s-triazolopyridazine, which bore SH, NH and/or OH groups, were carried out with dimethylformamide dimethyl acetal to give the corresponding S-, N- and/or O-methyl derivatives in high yields.Selective methylation of some compounds containing both SH and NH groups took place to give first the S-methyl and subsequently the S,N-dimethyl derivatives.No side reactions, such as C-methylation, were observed.