59086-11-2

Basic information

• Product Name: 2-(4-methoxyphenyl)-5-phenylthiophene
• Synonyms: 2-(4-methoxyphenyl)-5-phenylthiophene
• CAS NO: 59086-11-2
• Molecular Weight: 266.364
• Mol File: 59086-11-2.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: 2-(4-methoxyphenyl)-5-phenylthiophene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenyl)-5-phenylthiophene(59086-11-2)
• EPA Substance Registry System: 2-(4-methoxyphenyl)-5-phenylthiophene(59086-11-2)

Safety Data

• Hazardous Substances Data: 59086-11-2(Hazardous Substances Data)

Upstream product

• 29488-24-2 2-Bromo-5-phenyl-thiophene 
• 5720-07-0 4-methoxyphenylboronic acid 
• 825-55-8 2-phenylthiophene 
• 623-12-1 4-chloromethoxybenzene 
• 932-87-6 1-Bromo-2-phenylacetylene 
• 768-60-5 4-methoxyphenylacetylen 
• 536-74-3 phenylacetylene 
• 100-66-3 methoxybenzene 
• 696-62-8 para-iodoanisole 
• 16900-79-1 2-methyl-6-phenylhexa-3,5-diyn-2-ol 
• 22145-08-0 (E,E)-1-(4-methoxyphenyl)-4-phenyl-1,3-butadiene 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 42545-43-7 2-(4-methoxyphenyl)thiophene 
• 98-80-6 phenylboronic acid 

Downstream Products

• 860442-72-4 4-(5-phenyl-2-thienyl)phenol 

Relevant articles and documents

Palladium/Copper Dual Catalysis for the Cross-Coupling of Aryl(trialkyl)silanes with Aryl Bromides

Whereas aryl(trialkyl)silanes are considered to be ideal organometallic reagents for cross-coupling reactions owing to their stability, low toxicity, solubility, and easy accessibility, they are generally inert under typical cross-coupling conditions. Disclosed herein is a palladium/copper catalytic system that enables the cross-coupling of trimethyl, triethyl, tert-butyldimethyl, and triisopropyl aryl silanes with aryl bromides. This process is applicable to the sequential C?H and C?Si bond arylation of thiophenes and the synthesis of poly(thiophene–fluorene)s.

One-pot synthesis of unsymmetrical 1,3-butadiyne derivatives and their application in the synthesis of unsymmetrical 2,5-diarylthiophenes

A one-pot protocol was developed for the synthesis of unsymmetrical 1,3-butadiynes. The procedure is based on two sequential reactions: deprotection of R–C≡C–C≡C– C(Me)2OH derivatives in a retro-Favorskii reaction to furnish a terminal 1,3-butadiyne compound, which reacted with aryl iod-ides in a Sonogashira-type cross-coupling reaction catalyzed by Pd(PPh3)4 and CuI, using TBAOH as activator and toluene as solvent under reflux for 10 min. We also studied in situ thiocycli-zation of 1,3-butadiynes, leading to unsymmetrical 2,5-diaryl-thiophenes. The principal features of this method are operational simplicity, good substrate scope, very fast reaction, and high yields.

N-Heterocyclic carbene-Pd(II)-1-methylimidazole complex catalyzed C[sbnd]H bond arylation of (benzo)thiophenes with aryl chlorides

NHC-Pd(II)-Im complex showed efficient catalytic activity toward the direct C[sbnd]H bond arylation of (benzo)thiophenes with the challenging aryl chlorides. Under the suitable conditions, all reactions proceeded smoothly to give the desired C[sbnd]H bond