F:Flammable;
590-92-1Relevant articles and documents
A aldehyde or mellow directly converted into the carboxylic acid (by machine translation)
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Paragraph 0068-0070, (2018/08/03)
The invention discloses a aldehyde or mellow oxidation can be directly transformed into carboxylic acid, is characterized in that the pure oxygen environment, in N - hydroxy imide compound under the catalysis of the imide compound or N - hydroxy and nitrous acid ester compound common under the catalysis, the CH2 OH and CHO oxidation directly converted into the carboxylic acid compounds. The invention using oxygen as the oxidizing agent, does not add any metal catalyst, environment-friendly, high catalytic efficiency, simple and convenient operation. With the previous metal catalytic system complex and different catalytic system, has some metal catalytic system in the process, the use of transition metal will cause the transition metal of the residual, the invention adopts the non-metallic catalytic system, environmental protection, preventing the metal residue problem, this to the solution of the drug in the synthesis of transition metal residue problem and provides a new method of thinking. (by machine translation)
METHOD OF MAKING ACRYLIC ACID FROM LACTIC ACID OR LACTIDE USING MOLTEN SALT CATALYSTS
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Page/Page column 42-54, (2018/09/28)
A method of making acrylic acid in liquid phase by contacting a feed stream containing lactic acid, lactide, or mixtures thereof with a molten salt catalyst comprising a protic ionic liquid (PIL), which contains a bromide anion (Br-), is provided.
Catalytic Bromination of Alkyl sp3C-H Bonds with KBr/Air under Visible Light
Zhao, Mengdi,Lu, Wenjun
supporting information, p. 5264 - 5267 (2018/09/12)
Alkyl sp3C-H bonds of cycloalkanes and functional branch/linear alkanes have been successfully brominated with KBr using air or O2 as an oxidant at room temperature to 40 °C. The reactions are carried out in the presence of catalytic NaNO2 in 37% HCl (aq)/solvent under visible light, combining aerobic oxidations and photochemical radical processes. For various alkane substrates, CF3CH2OH, CHCl3, or CH2Cl2 is employed as an organic solvent, respectively, to enhance the efficiency of bromination.
Preparation method of alkane brominated material
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Paragraph 0067-0068, (2018/09/08)
The invention relates to a preparation method of an alkane brominated material. The preparation method comprises the following steps: adding alkane, a bromine-containing compound or elemental bromine,a catalyst and acid into a solvent; adding the solvent into a light-transmission reaction container under air or oxygen atmosphere; sealing; performing stirring reaction under constant pressure and light illumination conditions; then analyzing a nuclear magnetic yield, and performing extraction, drying, filtration, distillation under reduced pressure and column separation to obtain the alkane brominated material. Compared with the prior art, the preparation method disclosed by the invention has the advantages that by using low-cost and safe bromic salt as a bromine source, the air as an oxidizing agent and a nitrogen-containing reagent as the catalyst, reaction is carried out under the conditions of constant temperature and constant pressure, so that energy conservation and economy are realized, and the preparation method is convenient and safe to operate and is environmentally friendly.
METHODS OF MAKING ACRYLIC ACID FROM LACTIC ACID OR ITS DERIVATIVES IN LIQUID PHASE
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Page/Page column 67, (2018/02/28)
Methods for making acrylic acid, acrylic acid derivatives, or mixtures thereof by contacting a feed stream containing lactic acid, lactic acid derivatives, or mixtures thereof with a molten salt catalyst comprising an ionic liquid (IL) and an acid in liquid phase are provided.
CATALYSTS FOR MAKING ACRYLIC ACID FROM LACTIC ACID OR ITS DERIVATIVES IN LIQUID PHASE
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Page/Page column 67, (2018/02/28)
Catalysts for the dehydration of lactic acid, lactic acid derivatives, or mixtures thereof to acrylic acid, acrylic acid derivatives, or mixtures thereof in liquid phase comprising an ionic liquid (IL) and an acid are provided.
A versatile and stereocontrolled total synthesis of dihydroxylated docosatrienes containing a conjugated E,E,Z-triene
Dayaker, Gandrath,Durand, Thierry,Balas, Laurence
supporting information, p. 2879 - 2887 (2014/03/21)
A versatile strategy featuring a Colvin rearrangement, hydrozirconation, a Sonogashira cross-coupling reaction and a Z-selective Wittig olefination, was successfully developed for the construction of a conjugated E,E,Z-triene subunit, flanked on both sides by two Z-allylic hydroxyl groups. This chemical pattern is found in many endogenous lipid metabolites such as maresin1 (MaR1), neuroprotectinD1 (NPD1), and its aspirin triggered-isomer AT-NPD1, which not only counter-regulate inflammation but also actively orchestrate (at nanomolar doses) the resolution and termination program of acute inflammation while promoting wound healing, return to homeostasis and neuroprotection. Unlike previous approaches, the advantages of the present strategy are obvious, as it allows us to modify the nonpolar tail, the carboxylated head or both ends of the molecule without repeating the whole synthetic sequence (about 26-34steps according to the literature). Thus, the first total syntheses of NPD1 methyl ester epimer (which can also be considered as an enantiomer of AT-NPD1) and its n-3 docosapentaenoic acid derived analogue were achieved from a highly functionalized and late advanced pivotal intermediate. This innovative route may be easily adapted to gain access to other dihydroxylated metabolites and analogues of polyunsaturated fatty acids containing a conjugated E,E,Z-triene subunit. Different epimers/diastereoisomers may be obtained by purchasing the suitable optically pure (S)- and/or (R)-1,2,4-butanetriol(s) as a chiral pool for both stereogenic centers. Modification is key: Two total syntheses of dihydroxylated and noncyclic metabolites of polyunsaturated fatty acids, that is, NPD1 methyl ester epimer and its n-3 docosapentaenoic acid (DPA)-derived analogue, were achieved from a highly functionalized and late advanced pivotal intermediate (see scheme).
Synthesis of [3-13C]-, [4-13C]- and [11- 13C]-porphobilinogen
Dawadi, Prativa B. S.,Schulten, Els A. M.,Lugtenburg, Johan
experimental part, p. 341 - 349 (2011/07/08)
[4-13C]-porphobilinogen 1a, [3-13C]-porphobilinogen 1b and [11-13C]-porphobilinogen 1c are prepared from [1- 13C]-3-(tetrahydropyran-20-yloxy)-propionaldehyde 2a, methyl [4- 13C]-4-nitrobutyrate 3b and [1-13C]-isocyanoacetonitrile 5c, respectively. The building blocks 2, 3 and 5 can be prepared efficiently in any isotopomeric form. Via base-catalyzed condensation of these building blocks porphobilinogen can be enriched with 13C and 15N stable isotopes at any position and combination of positions. Copyright
An efficient method for the synthesis of aliphatic acids using microwaves
Brǎtulescu, George
, p. 161 - 163 (2007/10/03)
Aliphatic acids are prepared by reaction of nitriles with phtalic acid by irradiation under microwaves in a domestic oven.
Montmorillonite clay: A novel reagent for the chemoselective hydrolysis of t-butyl esters
Yadav,Reddy, B. V. Subba,Rao, K. Sanjeeva,Harikishan
, p. 826 - 828 (2007/10/03)
A mild and highly selective hydrolysis of t-butyl esters has been achieved in high yields using montmorillonite KSF in refluxing acetonitrile. The method is compatible with a variety of protecting and functional groups such as BOC, Cbz, propargyl, allyl, benzyl, t-butyl ethers, allyl, methyl and benzyl esters present in the molecule.
