58711-02-7

Basic information

• Product Name: 2-Ethylphenylhydrazine hydrochloride
• Synonyms: 2-ETHYLPHENYLHYDRAZINE HCL;1-(2-ETHYLPHENYL)HYDRAZINE HYDROCHLORIDE;O-ETHYLPHENYLHYDRAZINE MONOHYDROCHLORIDE;TIMTEC-BB SBB003825;2-EthylPhenylHydrazineHcl98.5%;2-Ethlpenyloy drazine hydrochlorid;2-Ethylphenylhydrazine hydrochloride;2-Ethylphenylhydrazi
• CAS NO: 58711-02-7
• Molecular Formula: C₈H₁₂N₂*ClH
• Molecular Weight: 172.66
• Product Categories: Phenylhydrazine;Phenyls & Phenyl-Het
• Mol File: 58711-02-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 178 °C (dec.)(lit.)
• Boiling Point: 247.7°C at 760 mmHg
• Flash Point: 118.9°C
• Appearance: /
• Density: 1.056g/cm³
• Vapor Pressure: 0.0253mmHg at 25°C
• Refractive Index: 1.603
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 2-Ethylphenylhydrazine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Ethylphenylhydrazine hydrochloride(58711-02-7)
• EPA Substance Registry System: 2-Ethylphenylhydrazine hydrochloride(58711-02-7)

Safety Data

• Hazard Codes: Xn,N
• Statements: 22-36/37/38-43-50/53
• Safety Statements: 26-36/37-60-61
• RIDADR: UN 3077 9/PG 3
• WGK Germany: 3
• F: 1-10
• HazardClass: IRRITANT
• Hazardous Substances Data: 58711-02-7(Hazardous Substances Data)

Usage

Description

2-Ethylphenylhydrazine hydrochloride is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceuticals. It is a white crystalline solid with a chemical structure that features an ethyl group attached to a phenyl ring, which is connected to a hydrazine group. 2-Ethylphenylhydrazine hydrochloride is known for its reactivity and is used in the production of non-steroidal anti-inflammatory drugs (NSAIDs) due to its ability to selectively inhibit cyclooxygenase-2 (COX-2).

Uses

Used in Pharmaceutical Industry:
2-Ethylphenylhydrazine hydrochloride is used as a key starting material for the synthesis of Etodolac (E933100), a non-steroidal anti-inflammatory drug (NSAID). Etodolac is known for its selective inhibition of COX-2, which is an enzyme involved in the production of prostaglandins that cause inflammation and pain. By inhibiting COX-2, Etodolac exhibits anti-inflammatory and analgesic properties, making it an effective treatment for conditions such as arthritis and other inflammatory disorders.
Used in Research and Development:
In addition to its pharmaceutical applications, 2-Ethylphenylhydrazine hydrochloride is also utilized in research and development for the discovery and development of new COX-2 inhibitors and other related compounds. Its reactivity and structural features make it a valuable tool for exploring the structure-activity relationships of COX-2 inhibitors and for designing novel therapeutic agents with improved efficacy and reduced side effects.

InChI:InChI=1/C8H12N2/c1-2-7-5-3-4-6-8(7)10-9/h3-6,10H,2,9H2,1H3

Upstream product

• 578-54-1 ortho-ethylaniline 

Downstream Products

• 41340-36-7 7-ethyl-2-(1H-indol-3-yl)ethan-1-ol 
• 19275-56-0 8-ethyl-2,3,4,9-tetrahydrocarbazole 
• 866732-48-1 N’-(2-ethylphenyl)benzohydrazide 
• 1226954-31-9 C₁₂H₁₈N₂O 

Relevant articles and documents

Design, synthesis and biological evaluation of glutamic acid derivatives as anti-oxidant and anti-inflammatory agents

A series of glutamic acid derivatives was synthesized and evaluated for their antioxidant activity and stability. We found several potent and stable glutamic acid derivatives. Among them, compound 12b exhibited good in vitro activity, chemical stability and cytotoxicity. A prototype compound 12b showed an anti-inflammatory effect in LPS-stimulated RAW 264.7 cell lines and in a zebrafish model.

Synthesis, crystal structure and fungicidal activities of new type oxazolidinone-based strobilurin analogues

A series of oxazolidinone-based strobilurin analogues were efficiently synthesized by the reaction of 3-(2-bromomethylphenyl) oxazolidin-2-one with 1-substituted phenyl-2H-pyrazolin-3-one. Their structures were confirmed and characterized by 1H-NMR, 13C-NMR, elemental analysis, and mass spectroscopy. In addition, the crystal structure of the target compound 3-(2-((1-phenyl-2H-pyrazol-3-yloxy)methyl)phenyl) oxazolidin-2-one was determined by single crystal X-ray diffraction. The bioassay results of these compounds indicated that some of the oxazolidin-2-one derivatives containing N-substituted phenyl 2H-pyrazol ring exhibited potential in vivo fungicidal activities against M. grisea at the dosage of 1 g L-1.