587-79-1

Basic information

• Product Name: 4-FLUORODIPHENYLMETHANE
• Synonyms: 4-FluorodiphenylmethaneDISC 05/09/02 see # 9194;1-Benzyl-4-fluorobenzene;4-FLUORODIPHENYLMETHANE;4-Fluorodiphenylmethane 99%;4-Fluorodiphenylmethane99%
• CAS NO: 587-79-1
• Molecular Formula: C₁₃H₁₁F
• Molecular Weight: 186.22
• Mol File: 587-79-1.mol
• Article Data: 85

Chemical Properties

• Boiling Point: 94°C 1mm
• Appearance: /
• Density: 1
• Refractive Index: 1.5540 to 1.5580
• CAS DataBase Reference: 4-FLUORODIPHENYLMETHANE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUORODIPHENYLMETHANE(587-79-1)
• EPA Substance Registry System: 4-FLUORODIPHENYLMETHANE(587-79-1)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 587-79-1(Hazardous Substances Data)

Usage

General Description

4-Fluorodiphenylmethane is a chemical compound with the molecular formula C13H11F. It is a white crystalline powder that is insoluble in water but soluble in organic solvents. 4-FLUORODIPHENYLMETHANE is used in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It is also used as a building block in organic chemistry to create a variety of different compounds. While it has potential uses in various industries, 4-fluorodiphenylmethane should be handled with care and in accordance with proper safety precautions due to its potential health hazards if mishandled.

Upstream product

• 352-11-4 1-chloromethyl-4-fluorobenzene 
• 71-43-2 benzene 
• 345-83-5 4-fluorobenzophenone 
• 149099-27-4 4-fluorobenzhydrol 
• 462-06-6 fluorobenzene 
• 100-44-7 benzyl chloride 
• 352-34-1 4-fluoro-1-iodobenzene 
• 100-39-0 benzyl bromide 
• 108-86-1 bromobenzene 
• 3831-29-6 4-fluorobenzyl iodide 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 459-57-4 4-fluorobenzaldehyde 
• 185246-53-1 2-(4-fluorophenyl)-1,3-dioxane 
• 101-81-5 Diphenylmethane 

Downstream Products

• 1026466-52-3 1-[4-(4-fluorobenzyl)phenyl]ethan-1-one 
• 101-81-5 Diphenylmethane 
• 106147-65-3 4-[2-(4-Fluoro-phenyl)-2-phenyl-ethyl]-1H-imidazole 
• 1058345-45-1 2,2,2-trichloroethyl 4-fluorobenzhydrylcarbamate 
• 345-83-5 4-fluorobenzophenone 
• 1169764-45-7 methyl 5-((4-fluorophenyl)(phenyl)methyl)-2-methoxybenzoate 
• 1237743-72-4 1-(3-(4-fluorophenyl)-3-phenylprop-1-ynyl)benzene 
• 1326231-75-7 1-((4-fluorophenyl)(phenyl)methyl)-1H-benzo[d]imidazole 
• 1393444-68-2 (4-tert-butylphenyl)(4-fluorophenyl)phenylmethane 
• 153877-48-6 (phenyl)(p-fluorophenyl)methanol acetate 
• 1425513-32-1 1-(4-fluorophenyl)-6-((4-fluorophenyl)(phenyl)methyl)-2,3-diphenyl-1H-indene 
• 1425513-41-2 5-fluoro-6-((4-fluorophenyl)(phenyl)methyl)-1,2,3-triphenyl-1H-indene 
• 1443984-99-3 C₂₃H₁₇F 
• 1443985-00-9 C₂₀H₁₄FN 

Relevant articles and documents

Nickel-Catalyzed Electrochemical C(sp3)?C(sp2) Cross-Coupling Reactions of Benzyl Trifluoroborate and Organic Halides**

Reported here is the redox neutral electrochemical C(sp2)?C(sp3) cross-coupling reaction of bench-stable aryl halides or β-bromostyrene (electrophiles) and benzylic trifluoroborates (nucleophiles) using nonprecious, bench-stable NiCl2?glyme/polypyridine catalysts in an undivided cell configuration under ambient conditions. The broad reaction scope and good yields of the Ni-catalyzed electrochemical coupling reactions were confirmed by 50 examples of aryl/β-styrenyl chloride/bromide and benzylic trifluoroborates. Potential applications were demonstrated by electrosynthesis and late-stage functionalization of pharmaceuticals and natural amino acid modification, and three reactions were run on gram-scale in a flow-cell electrolyzer. The electrochemical C?C cross-coupling reactions proceed through an unconventional radical transmetalation mechanism. This method is highly productive and expected to find wide-spread applications in organic synthesis.

Potassium trimethylsilanolate enables rapid, homogeneous suzuki-miyaura cross-coupling of boronic esters

Herein, a mild and operationally simple method for the Suzuki-Miyaura cross-coupling of boronic esters is described. Central to this advance is the use of the organic-soluble base, potassium trimethylsilanolate, which allows for a homogeneous, anhydrous cross-coupling. The coupling proceeds at a rapid rate, often furnishing products in quantitative yield in less than 5 min. By applying this method, a >10-fold decrease in reaction time was observed for three published reactions which required >48 h to reach satisfactory conversion.

Phosphonic acid mediated practical dehalogenation and benzylation with benzyl halides

For the first time, by using H3PO3/I2 system, various benzyl chlorides, bromides and iodides were dehalogenated successfully. In the presence of H3PO3, benzyl halides underwent electrophilic substitution reactions with electron-rich arenes, leading to a broad range of diarylmethanes in good yields. These transformations feature green, cheap reducing reagents and metal-free conditions. A possible mechanism was proposed.