57459-72-0

Basic information

• Product Name: HEPARIN MONOSULFATE SODIUM SALT
• Synonyms: Leparan;Sodium heparan sulfate;Sodium heparitin sulfate;HEPARITIN SULFATE;HEPARITIN SULFATE SODIUM-POTASSIUM SALT;HEPARITIN SULFATE SODIUM SALT;HEPARIN SULFATE BOVINE SODIUM SALT;HEPARIN SULFATE SODIUM SALT
• CAS NO: 57459-72-0
• Molecular Weight: 0
• EINECS: 232-939-9
• Mol File: 57459-72-0.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• Solubility: H2O: 1 mg/mL, clear, colorless
• CAS DataBase Reference: HEPARIN MONOSULFATE SODIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: HEPARIN MONOSULFATE SODIUM SALT(57459-72-0)
• EPA Substance Registry System: HEPARIN MONOSULFATE SODIUM SALT(57459-72-0)

Safety Data

• WGK Germany: 3
• F: 10
• Hazardous Substances Data: 57459-72-0(Hazardous Substances Data)

Usage

Description

HEPARIN MONOSULFATE SODIUM SALT is a sulfated polysaccharide derived from heparan sulfate, a naturally occurring glycosaminoglycan found in the extracellular matrix of animal tissues. It possesses anticoagulant properties and is known for its ability to modulate various biological processes.

Uses

Used in Pharmaceutical Industry:
HEPARIN MONOSULFATE SODIUM SALT is used as an antithrombotic agent for preventing blood clot formation and treating conditions related to abnormal blood clotting.
Used in Biomedical Research:
HEPARIN MONOSULFATE SODIUM SALT is used as a research tool for studying its effect on the proliferation of B cells, which helps in understanding the immune system and developing potential therapeutic strategies.
Used in Developmental Biology:
HEPARIN MONOSULFATE SODIUM SALT is used to monitor its role in eye development in E5 embryonic cells, providing insights into the molecular mechanisms underlying organogenesis and potential applications in regenerative medicine.
Used in Cell Biology:
HEPARIN MONOSULFATE SODIUM SALT is used to study its binding with exosome fibronectin in human trabecular meshwork cells using dot blot, which can contribute to the understanding of cell-cell interactions and the development of targeted therapies for various diseases.
Chemical Properties:
HEPARIN MONOSULFATE SODIUM SALT is also available in fractionated forms with lower molecular weights and different Anti-IIa activities, allowing for customization based on specific application requirements and research objectives.

Biochem/physiol Actions

Heparan sulphate (HS), a ubiquitous glycosaminoglycan, is a polymer of D-glucuronic acid or L-iduronic acid and D-glucosamine (GlcA) sugars. It is synthesized in the cis-Golgi as heparan. In Golgi, final heparan sulphate is synthesized in by the action of enzymes N- and O-HS-sulphotransferases and HS epimerase. The mature HS has 50 to 200 disaccharide units. It is part of the extracellular matrix (ECM) and plays a key role in the oncogenic pathway. Deregulation of heparin sulfate metabolism is implicated in cancer progression. HS is associated with the onset of infectious diseases and inflammatory conditions. HS interaction with Aβ fibrils contributes to the pathophysiology of Alzheimer′s disease.