57381-43-8 Usage
Description
Methyl 2,5-dibromobenzoate is an aromatic ester derived from 2,5-dibromobenzoic acid through a process of esterification with methanol. Methyl 2,5-dibromobenzoate has the unique property of undergoing Ni(0)-catalyzed polymerization, which allows it to form soluble polyphenylenes. These characteristics make it a versatile compound with potential applications in various industries.
Uses
Used in Chemical Synthesis:
Methyl 2,5-dibromobenzoate is used as a key intermediate in the synthesis of various organic compounds. Its ability to undergo Ni(0)-catalyzed polymerization makes it a valuable building block for creating complex molecular structures with potential applications in materials science and pharmaceuticals.
Used in Materials Science:
In the field of materials science, Methyl 2,5-dibromobenzoate is used as a monomer for the production of soluble polyphenylenes. These polymers exhibit unique properties, such as high thermal stability and excellent electrical conductivity, making them suitable for applications in electronic devices, sensors, and other advanced materials.
Used in Pharmaceutical Industry:
Methyl 2,5-dibromobenzoate is used as a starting material for the development of new pharmaceutical compounds. Its unique chemical structure and reactivity make it a promising candidate for the synthesis of novel drugs with potential therapeutic applications.
Used in Environmental Applications:
Methyl 2,5-dibromobenzoate can be utilized in the development of environmentally friendly materials and processes. For example, its polymerization properties can be harnessed to create biodegradable plastics or to develop new methods for the removal of pollutants from the environment.
Check Digit Verification of cas no
The CAS Registry Mumber 57381-43-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,3,8 and 1 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 57381-43:
(7*5)+(6*7)+(5*3)+(4*8)+(3*1)+(2*4)+(1*3)=138
138 % 10 = 8
So 57381-43-8 is a valid CAS Registry Number.
57381-43-8Relevant articles and documents
SAR Studies on Aromatic Acylhydrazone-Based Inhibitors of Fungal Sphingolipid Synthesis as Next-Generation Antifungal Agents
Del Poeta, Maurizio,Haranahalli, Krupanandan,Lazzarini, Cristina,Mallamo, John,McCarthy, J. Brian,Ojima, Iwao,Pathiranage, Senuri,Sun, Yi,Zambito, Julia
, (2019/09/06)
Recently, the fungal sphingolipid glucosylceramide (GlcCer) synthesis has emerged as a highly promising new target for drug discovery of next-generation antifungal agents, and we found two aromatic acylhydrazones as effective inhibitors of GlcCer synthesis based on HTP screening. In the present work, we have designed libraries of new aromatic acylhydrazones, evaluated their antifungal activities (MIC80 and time-kill profile) against C. neoformans, and performed an extensive SAR study, which led to the identification of five promising lead compounds, exhibiting excellent fungicidal activities with very large selectivity index. Moreover, two compounds demonstrated broad spectrum antifungal activity against six other clinically relevant fungal strains. These five lead compounds were examined for their synergism/cooperativity with five clinical drugs against seven fungal strains, and very encouraging results were obtained; e.g., the combination of all five lead compounds with voriconazole exhibited either synergistic or additive effect to all seven fungal strains.
Facile preparation of 6-(Aminomethyl)isoindolin-1-one realizing complete reduction of double aromatic cyano groups
Bi, Lei,Fu, Chenchao,Yao, Lei
, p. 6655 - 6657 (2015/02/19)
6-(Aminomethyl)isoindolin-1-one is a key intermediate enroute to many investigational therapeutic agents. The need for it prompts a concise synthesis, which includes; (1) cyanation without using costly transition metal catalysts; (2) complete hydrogenation of the resulting dicyanide. This synthetic route emphasizes high atom-efficiency and simple operation. 5-(Aminomethyl)isoindolin-1-one, a structural analogue, is synthesized via this route as well.
