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5721-37-9

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5721-37-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 5721-37-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,7,2 and 1 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 5721-37:
(6*5)+(5*7)+(4*2)+(3*1)+(2*3)+(1*7)=89
89 % 10 = 9
So 5721-37-9 is a valid CAS Registry Number.
InChI:InChI=1/C28H28BrNO6/c1-14(2)36-28(32)25-15(3)30-21-9-17(16-5-7-18(33-4)8-6-16)10-22(31)27(21)26(25)19-11-23-24(12-20(19)29)35-13-34-23/h5-8,11-12,14,17,26,30H,9-10,13H2,1-4H3

5721-37-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 9,10-Ethanoanthracene-9(10H)-propylamine

1.2 Other means of identification

Product number -
Other names Desmethylmaprotiline

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:5721-37-9 SDS

5721-37-9Downstream Products

5721-37-9Relevant articles and documents

Cytochrome P-450 enzymes contributing to demethylation of maprotiline in man

Brachtendorf, Lars,Jetter, Alexander,Beckurts, K. Tobias,Hoelscher, Arnulf H.,Fuhr, Uwe

, p. 144 - 149 (2007/10/03)

From case reports of patients treated with the tetracyclic antidepressant drug maprotiline, it appears that this drug is subject to polymorphic metabolism. Thus, we studied formation of the major maprotiline metabolite desmethylmaprotiline to identify the human cytochrome P-450 enzymes (CYP) involved. In incubations with human liver microsomes from two different donors, the substrate maprotiline was used at five different concentrations (5 to 500 μM). For selective inhibition of CYPs, quinidine (0.5-50 μM; CYP2D6), furafylline (0.3-30 μM; CYP1A2), ketoconazole (0.2-20 μM; CYP3A4), mephenytoin (20-200 μM; CYP2C19), chlorzoxazone (1-100 μM; CYP2E1), sulphaphenazole (0.2-100 μM; CYP2C9) and coumarin (0.2-100 μM; CYP2A6) were used. Desmethylmaprotiline concentrations were measured by HPLC, and enzyme kinetic parameters were estimated using extended Michaelis-Menten equations with non-linear regression. Relevant inhibition of the desmethylmaprotiline formation rate was observed in incubations with quinidine, furafylline and ketoconazole only. Formation rates of desmethylmaprotiline were consistent with a two enzyme model with a high (KM=71 and 84 μM) and a low (KM=531 and 426 μM) affinity site for maprotiline in the two samples, respectively. The high affinity site was competitively inhibited by quinidine (Ki,c 0.13 and 0.61 μM), the low-affinity site was non-competitively inhibited by furafylline (Ki,nc 0.11 and 1.3 μM). Thus it appears that CYP2D6 and CYP1A2 contribute to maprotiline demethylation. Based on the parameters obtained, for plasma concentrations of 1 μM 83% (mean) of desmethylmaprotiline formation in vivo is expected to be mediated by CYP2D6 while 17% only may be attributed to CYP1A2 activity.

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