57196-62-0

Basic information

• Product Name: 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride
• Synonyms: 6-Methoxy-1,2,3,4-tetrahydrois;1,2,3,4-tetrahydro-6-methoxyisoquinoline hydrochloride;Isoquinoline, 1,2,3,4-tetrahydro-6-Methoxy-, hydrochloride;6-Methoxy-1,2,3,4-tetraihydroisoquinoline hydrochloride;6-METHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE HCL;6-METHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE;ISOQUINOLINE 1,2,3,4-TETRAHYDRO-6-METHOXY HCL SALT;Isoquinoline,1,2,3,4-tetrahydro-6-methoxy-,hydrochloride(1:1)
• CAS NO: 57196-62-0
• Molecular Formula: C₁₀H₁₃NO*ClH
• Molecular Weight: 199.68
• EINECS: -0
• Product Categories: API intermediates
• Mol File: 57196-62-0.mol
• Article Data: 9

Chemical Properties

• Melting Point: 230-232.5°C
• Boiling Point: 283.6 °C at 760 mmHg
• Flash Point: 109.2 °C
• Appearance: /
• Vapor Pressure: 0.00313mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride(57196-62-0)
• EPA Substance Registry System: 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride(57196-62-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-51
• HazardClass: IRRITANT
• Hazardous Substances Data: 57196-62-0(Hazardous Substances Data)

Usage

Description

6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride is an organic compound belonging to the tetrahydroisoquinoline class, which are heterocyclic compounds consisting of a benzene ring attached to an isoquinoline. 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride features a methoxy functional group on the aromatic ring, and its molecular and structural characteristics significantly influence its specific use, toxicity, and biological activity. Many tetrahydroisoquinoline derivatives are known for their pharmaceutical properties and are utilized in the field of medicinal chemistry.

Uses

Used in Pharmaceutical Industry:
6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride is used as a pharmaceutical compound for its potential medicinal properties. Its synthesis and study are driven by the need to explore its therapeutic applications, which may include various health-related benefits due to its chemical structure and interactions with biological systems.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride is used as a research compound to investigate its chemical properties, potential interactions with biological targets, and possible applications in drug development. Its role in this context is to contribute to the understanding of tetrahydroisoquinoline derivatives and their potential as therapeutic agents.

InChI:InChI=1/C10H13NO.ClH/c1-12-10-3-2-9-7-11-5-4-8(9)6-10;/h2-3,6,11H,4-5,7H2,1H3;1H

Upstream product

• 14446-29-8 6-Methoxy-3,4-dihydroisoquinoline 
• 942150-85-8 bis(6-methoxy-N-1,2,3,4-tetrahydroisoquinolinyl)methane 
• 110339-54-3 N-[2-(3-methoxy-phenyl)-ethyl]-formamide 
• 50-00-0 formaldehyd 
• 55-81-2 4-Methoxyphenethylamine 
• 42923-77-3 6-methoxy-1,2,3,4-tetrahydro-isoquinoline 
• 2039-67-0 2-(3-methoxyphenyl)-1-ethanamine 
• 3179-09-7 1-methoxy-3-(2-nitrovinyl)benzene 
• 591-31-1 3-methoxy-benzaldehyde 

Downstream Products

• 59839-23-5 6-hydroxy-1,2,3,4-tetrahydroisoquinoline hydrobromide 
• 1429253-97-3 C₂₈H₂₆N₄O₂ 
• 1429253-99-5 C₂₃H₂₃N₃O₃ 
• 1429254-04-5 C₂₄H₂₅N₃O₃ 
• 42923-77-3 6-methoxy-1,2,3,4-tetrahydro-isoquinoline 
• 158984-83-9 N-tert-butoxycarbonyl-6-hydroxy-1,2,3,4-tetrahydroisoquinoline 
• 164148-88-3 6-benzyloxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 
• 630407-52-2 6-ethoxy-1,2,3,4-tetrahydro-isoquinoline 
• 252061-94-2 6-benzyloxy-1,2,3,4-tetrahydro-isoquinoline 
• 94085-74-2 6-hydroxy-2-(3-methoxybenzyl)-1,2,3,4-tetrahydroisoquinoline 
• 1064199-05-8 2-(3-methoxybenzyl)-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline 
• 860436-57-3 tert-butyl 6-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 1064200-01-6 2-(3,5-dimethoxybenzoyl)-6-hydroxy-1,2,3,4-tetrahydroisoquinoline 
• 1064205-99-7 2-(2-methoxybenzyl)-1,2,3,4-tetrahydroisoquinolin-6-ol 

Relevant articles and documents

Synthesis of 2-substituted tetrahydroisoquinolin-6-ols: Potential scaffolds for estrogen receptor modulation and/or microtubule degradation

6-Methoxytetrahydroisoquinoline hydrochloride was converted into four small libraries of substituted ureas, thioureas, sulfonamides and N-aryls, using the tetrahydroisoquinoline nitrogen as the scaffold-linking atom. Some of the compounds were evaluated for their ability to inhibit cell proliferation using the MCF7 (invasive ductal carcinoma) cell line.

PROCESS FOR THE PREPARATION OF SUBSTITUTED-1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES

The present invention is directed to a process for the synthesis of substituted-1,2,3,4-tetrahydroisoquinoline derivatives, useful as intermediates in the synthesis of pharmaceutical agents.

5-HT7 receptor antagonists

The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline substituted sulfonamide compounds of the formula I: to processes of preparation of such compounds, to pharm