57147-21-4

Basic information

• Product Name: 2-Pyrrolidinone, 5-hydroxy-1-phenyl-
• CAS NO: 57147-21-4
• Molecular Formula: C10H11NO2
• Molecular Weight: 177.203
• Mol File: 57147-21-4.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-Pyrrolidinone, 5-hydroxy-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyrrolidinone, 5-hydroxy-1-phenyl-(57147-21-4)
• EPA Substance Registry System: 2-Pyrrolidinone, 5-hydroxy-1-phenyl-(57147-21-4)

Safety Data

• Hazardous Substances Data: 57147-21-4(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 102-14-7 N-phenyl-succinamic acid 
• 4641-57-0 1-phenylpyrrolidin-2-one 
• 146500-35-8 methyl 1-phenyl-5-oxo-2-pyrrolidinecarboxylate 
• 757248-55-8 1-phenyl-4-[1,2,3-triazol-5-ylcarbonyl]pyrrolidin-2-one 
• 757248-59-2 1-phenyl-5-[pyrazol-5-ylcarbonyl]pyrrolidin-2-one 
• 757248-80-9 1-phenyl-5-(tetrazol-5-ylacetyl)pyrrolidin-2-one 
• 757248-77-4 5-cyanoacetyl-1-phenylpyrrolidin-2-one 
• 55609-31-9 5-Ethoxy-1-phenyl-pyrrolidin-2-one 
• 83-25-0 N-phenylmaleimide 

Downstream Products

• 58804-56-1 1-phenyl-5-acetonyl-2-pyrrolidinone 
• 38015-73-5 1-phenyl-3a,4,5,11b-tetrahydrodipyrrolo[1,2-a:3',2'-c]quinoline-2,6-dione 
• 58966-86-2 5-anilino-1-phenyl-pyrrolidin-2-one 
• 88612-68-4 2-(5-oxo-1-phenylpyrrolidin-2-yl)acetic acid 
• 58804-59-4 1-phenyl-5-phenacyl-2-pyrrolidinone 
• 58804-70-9 1-phenyl-5-(nitromethyl)-2-pyrrolidinone 

Relevant articles and documents

Chemoselective Electrosynthesis Using Rapid Alternating Polarity

Challenges in the selective manipulation of functional groups (chemoselectivity) in organic synthesis have historically been overcome either by using reagents/catalysts that tunably interact with a substrate or through modification to shield undesired sites of reactivity (protecting groups). Although electrochemistry offers precise redox control to achieve unique chemoselectivity, this approach often becomes challenging in the presence of multiple redox-active functionalities. Historically, electrosynthesis has been performed almost solely by using direct current (DC). In contrast, applying alternating current (AC) has been known to change reaction outcomes considerably on an analytical scale but has rarely been strategically exploited for use in complex preparative organic synthesis. Here we show how a square waveform employed to deliver electric current - rapid alternating polarity (rAP) - enables control over reaction outcomes in the chemoselective reduction of carbonyl compounds, one of the most widely used reaction manifolds. The reactivity observed cannot be recapitulated using DC electrolysis or chemical reagents. The synthetic value brought by this new method for controlling chemoselectivity is vividly demonstrated in the context of classical reactivity problems such as chiral auxiliary removal and cutting-edge medicinal chemistry topics such as the synthesis of PROTACs.

Preparation method of hydroxyl lactam

The invention discloses a preparation method of hydroxyl lactam. The hydroxyl lactam is prepared from cyclic imide shown in a formula (II) through a homogeneous catalytic hydrogenation reaction, wherein R1, R2 and R3 are respectively and independently H,

Stereoselective cycloaddition of N-acyliminium ions with α,β-unsaturated ketones and esters

The [4+2] reactions of N-acyliminium ions, produced from 2-aryl-3-hydroxy-2,3-dihydroisoindol-1-onesor5-hydroxy-1-phenyl-2,5-dihydro/2,3,4,5-tetrahydropyrrol-2-ones in the presence of BF3OEt2, with α,β-unsaturated ketones or esters w