57139-25-0

Basic information

• Product Name: N-methoxy-2-methylbenzamide
• Synonyms: N-methoxy-2-methylbenzamide
• CAS NO: 57139-25-0
• Molecular Weight: 165.192
• Mol File: 57139-25-0.mol
• Article Data: 22

Chemical Properties

• CAS DataBase Reference: N-methoxy-2-methylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-methoxy-2-methylbenzamide(57139-25-0)
• EPA Substance Registry System: N-methoxy-2-methylbenzamide(57139-25-0)

Safety Data

• Hazardous Substances Data: 57139-25-0(Hazardous Substances Data)

Upstream product

• 2446-51-7 N-methoxybenzamide 
• 74-88-4 methyl iodide 
• 67-62-9 O-Methylhydroxylamin 
• 933-88-0 ortho-toluoyl chloride 
• 118-90-1 ortho-methylbenzoic acid 
• 593-56-6 N-methoxylamine hydrochloride 
• 98-88-4 benzoyl chloride 

Downstream Products

• 1268451-41-7 (E)-2-methyl-6-styrylbenzamide 
• 491-30-5 1-isoquinolone 
• 132-90-1 3-n-butyl-1(2H)-isoquinolinone 
• 59524-94-6 4-ethoxy-2-(o-tolyl)quinazoline 

Relevant articles and documents

Isoindolinone synthesis through Rh/Cu-catalyzed oxidative C-H/N-H annulation of N -methoxy benzamides with saturated ketones

The synthesis of isoindolinones from N-methoxy benzamides and saturated ketones via a bimetallic tandem catalytic annulation has been accomplished. The reaction is catalyzed by a Rh/Cu-cocatalytic system and proceeds via the combination of Cu-catalyzed de

Three-Component Synthesis of Isoquinoline Derivatives by a Relay Catalysis with a Single Rhodium(III) Catalyst

A rhodium(III)-catalyzed one-pot three-component reaction of N-methoxybenzamide, α-diazoester, and alkyne was developed, providing an alternative way to synthesize isoquinoline derivatives. Mechanistically, it is a relay catalysis, and the reaction occurred via successive O-alkylation and C-H activation processes, both of which were promoted by the same catalyst.

Selective mono-alkylation of N-methoxybenzamides

We report our latest discovery of norbornene derivative modulated highly mono-selective ortho-C-H activation alkylation reactions on arenes bearing simple mono-dentate coordinating groups. The reaction features the use of readily available benzamides and alkyl halides. During the study, we prepared 30 mono-alkylated aryl amides in good yields with good mono-selectivity. We have also demonstrated that structurally rigid alkenes such as norbornene and its derivatives are a good class of ligand and could be used for future direct C-H functionalizations. The utilization of norbornene type ligands for assistance in C-H activation processes has opened a new window for future molecular design using direct C-H functionalization strategies.