5702-74-9

Basic information

• Product Name: 4-ISOPROPYLACETANILIDE
• Synonyms: 4-ISOPROPYLACETANILIDE;N-(4-ISOPROPYL-PHENYL)-ACETAMIDE;N1-(4-ISOPROPYLPHENYL)ACETAMIDE
• CAS NO: 5702-74-9
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.24
• Mol File: 5702-74-9.mol
• Article Data: 31

Chemical Properties

• Melting Point: 101-103°C
• Boiling Point: 323.7°Cat760mmHg
• Flash Point: 191.1°C
• Appearance: /
• Density: 1.026g/cm³
• Vapor Pressure: 3.11E-09mmHg at 25°C
• Refractive Index: 1.552
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-ISOPROPYLACETANILIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ISOPROPYLACETANILIDE(5702-74-9)
• EPA Substance Registry System: 4-ISOPROPYLACETANILIDE(5702-74-9)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22
• Safety Statements: 22-36/37/39
• Hazardous Substances Data: 5702-74-9(Hazardous Substances Data)

Usage

General Description

4-ISOPROPYLACETANILIDE, also known as 4-isopropylacetanilide or para-Isopropylacetanilide, is an organic compound with the chemical formula C11H15NO. It is a white, crystalline solid that is commonly used as an intermediate in the production of pharmaceuticals, particularly as an intermediate in the synthesis of the analgesic and antipyretic drug, acetaminophen (paracetamol). 4-ISOPROPYLACETANILIDE is also used in the cosmetic and personal care industry as an ingredient in hair and skin care products. The compound is known to have analgesic and anti-inflammatory properties, making it a valuable ingredient in various medicinal and cosmetic applications.

InChI:InChI=1/C16H18N2O3/c1-11-14(16(19)17-10-13-8-5-9-20-13)15(18-21-11)12-6-3-2-4-7-12/h2-4,6-7,13H,5,8-10H2,1H3,(H,17,19)

Upstream product

• 1817-47-6 4-nitrocumene 
• 10387-40-3 potassium thioacetate 
• 99-88-7 4-Isopropylaniline 
• 123-54-6 acetylacetone 
• 4218-48-8 1-ethyl-4-isopropylbenzene 
• 75-36-5 acetyl chloride 
• 67-64-1 acetone 
• 2033-24-1 cycl-isopropylidene malonate 
• 507-09-5 tiolacetic acid 
• 108-24-7 acetic anhydride 
• 215456-39-6 (-)-cryptone oxime 
• 127-09-3 sodium acetate 
• 2089-31-8 1-(4-isopropylphenyl)ethan-1-one oxime 
• 108-05-4 vinyl acetate 

Downstream Products

• 874947-55-4 N-Acetyl-N,N-di(4-isopropylphenyl)amine 
• 400858-42-6 butyl(4-isopropylphenyl)amine 
• 76842-12-1 N-(2-chloro-4-isopropylphenyl)acetamide 
• 895239-75-5 (E)-3-(3-isopropylphenyl)acrylaldehyde 
• 457928-84-6 (S)-3-(3-isopropylphenyl)butanal 
• 1401456-89-0 2-acetylamino-5-isopropylbenzoic acid ethyl ester 

Relevant articles and documents

Copper-promoted difunctionalization of unactivated alkenes with silanes

An efficient copper-catalyzed cascade difunctionalization of N-allyl anilines toward the synthesis of silylated indolines using commercially available silanes has been reported. This strategy provides a new avenue for the synthesis of a diverse array of i

An organocatalytic C-C bond cleavage approach: A metal-free and peroxide-free facile method for the synthesis of amide derivatives

A facile organocatalytic approach has been devised towards the synthesis of amide derivatives using 1,3-dicarbonyls as easily available acyl-sources under peroxide-free reaction conditions. This transformation was accomplished by the cleavage of the C-C bond in the presence of TEMPO as an organocatalyst and excludes the use of transition-metals and harsh reaction conditions. A broad range of substrates with diverse functional groups were well tolerated and delivered the products in high yields.

An Electrochemical Beckmann Rearrangement: Traditional Reaction via Modern Radical Mechanism

Abstract: Electrosynthesis as a potential means of introducing heteroatoms into the carbon framework is rarely studied. Herein, the electrochemical Beckmann rearrangement, i. e. the direct electrolysis of ketoximes to amides, is presented for the first time. Using a constant current as the driving force, the reaction can be easily carried out under neutral conditions at room temperature. Based on a series of mechanistic studies, a novel radical Beckmann rearrangement mechanism is proposed. This electrochemical Beckmann rearrangement does not follow the trans-migration rule of the classical Beckmann rearrangement.