56691-74-8

Basic information

• Product Name: Benzene, [[(2,6,6-trimethyl-1-cyclohexen-1-yl)methyl]sulfonyl]-
• Synonyms: 1-phenylsulfonylmethyl-2,6,6-trimethyl-1-cyclohexene
• CAS NO: 56691-74-8
• Molecular Formula: C16H22O2S
• Molecular Weight: 278.415
• Mol File: 56691-74-8.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzene, [[(2,6,6-trimethyl-1-cyclohexen-1-yl)methyl]sulfonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, [[(2,6,6-trimethyl-1-cyclohexen-1-yl)methyl]sulfonyl]-(56691-74-8)
• EPA Substance Registry System: Benzene, [[(2,6,6-trimethyl-1-cyclohexen-1-yl)methyl]sulfonyl]-(56691-74-8)

Safety Data

• Hazardous Substances Data: 56691-74-8(Hazardous Substances Data)

Usage

Description

Benzene, [[(2,6,6-trimethyl-1-cyclohexen-1-yl)methyl]sulfonyl]is a sulfonyl derivative of cyclohexene with a molecular formula of C14H20O2S. It features a benzene ring attached to a sulfonyl group, making it a versatile building block in organic synthesis.

Uses

Used in Pharmaceutical Industry:
Benzene, [[(2,6,6-trimethyl-1-cyclohexen-1-yl)methyl]sulfonyl]is used as a building block for the synthesis of pharmaceuticals due to its unique structure and properties, contributing to the development of new drugs.
Used in Agrochemical Industry:
This chemical compound is also utilized as a building block in the production of agrochemicals, playing a role in the synthesis of various agricultural products.
Used in Research and Industrial Processes:
Benzene, [[(2,6,6-trimethyl-1-cyclohexen-1-yl)methyl]sulfonyl]serves as a reagent in research and industrial processes, facilitating the development of new materials and compounds.
Used in the Development of New Materials:
Due to its unique structure, this chemical has potential applications in the development of innovative materials, expanding its utility beyond pharmaceuticals and agrochemicals.
It is crucial to handle Benzene, [[(2,6,6-trimethyl-1-cyclohexen-1-yl)methyl]sulfonyl]with care, as it may present health risks and environmental hazards if not properly managed.

Upstream product

• 56691-80-6 geranyl phenyl sulfone 
• 432-25-7 2,6,6-trimethylcyclohex-1-enecarbaldehyde 
• 56691-73-7 {[(2,6,6-trimethyl-1-cyclohexen-1-yl)methyl]thio}benzene 
• 472-20-8 β-cyclogeraniol 
• 79-77-6 (E)-β-ionone 
• 25996-10-5 (Z)-neryl bromide 
• 106-25-2 Nerol 
• 873-55-2 sodium benzenesulfonate 
• 6138-90-5 trans-geranyl bromide 
• 56881-52-8 (Z)-(3,7-dimethylocta-2,6-diene-1-sulfonyl)benzene 
• 59633-88-4 2-(bromomethyl)-1,3,3-trimethylcyclohex-1-ene 

Downstream Products

• 103905-01-7 1-acetoxy-8-hydroxy-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-9-(phenylsulfonyl)-2(E),6(E)-nonadiene 
• 1006607-15-3 (2E,6E)-9-benzenesulfonyl-9-(2,6,6-trimethylcyclohex-1-enyl)-3,7-dimethyl-1-(tetrahydro-2H-pyranyloxy)-2,6-nonadiene 
• 1006607-17-5 (2E,6E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)-1-(tetrahydro-2H-pyranyloxy)-2,6-nonadiene 
• 1086430-03-6 3-(2-(2,6,6-trimethylcyclohex-1-enyl)ethyl)furan 
• 150542-36-2 [(3E,7E)-5,9,9-Trimethoxy-3,7-dimethyl-1-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-3,7-diene-1-sulfonyl]-benzene 
• 150542-38-4 3,7-dimethyl-9-phenylsulfonyl-9-<2,6,6-trimethylcyclohex-1-enyl>nona-2,4,6-trienal 
• 105615-49-4 Acetic acid (2Z,6E)-9-benzenesulfonyl-8-hydroxy-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,6-dienyl ester 
• 90105-85-4 (2E,6E)-9-Benzenesulfonyl-8-hydroxy-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,6-dienoic acid methyl ester 
• 101822-24-6 {3-[2-Benzenesulfonyl-2-(2,6,6-trimethyl-cyclohex-1-enyl)-ethyl]-furan-2-yl}-trimethyl-silane 
• 85329-42-6 C₃₈H₄₆O₄S₃ 
• 134436-11-6 Trimethyl-(2,6,6-trimethyl-cyclohex-1-enylmethyl)-silane 
• 338389-09-6 1-(12-hydroxydodecyl-1-phenylsulfonyl)-2,6,6-trimethyl-1-cyclohexene 
• 514-62-5 ferruginol 
• 66408-58-0 3-(1-Benzenesulfonyl-3-oxo-butyl)-2,4,4-trimethyl-cyclohex-2-enone 

Relevant articles and documents

Enantioselective Synthesis Muqubilin and Negombatoperoxides B and C/D

Muqubilin, negombatoperoxide B, and negombatoperoxide C/D were synthesized through enantioselective routes, with the quaternary center derived from a peroxy chiral building block of known absolute configuration. The C-2/C-3 stereogenic centers were introduced by asymmetric aldol condensation, and the 1,2-dioxane ring was constructed via an intramolecular alkylation of a hydroperoxide with a mesylate. The synthetic samples showed physical and spectroscopic data consistent with those reported in the literature and thus verified the configurations of the natural products. A potentially more expeditious enantioselective entry to the 1,2-dioxane-aldol moiety (C-1 to C-6) of such cyclic peroxides was also briefly explored, where the C-2/C-3 stereogenic centers were installed through a [2+2] cycloaddition and the 1,2-dioxane ring was closed via an intramolecular alkylation coupled with an alkyl-oxygen cleavage of a β-lactone.

Synthesis, antimicrobial and antineoplastic activities for agelasine and agelasimine analogs with a β-cyclocitral derived substituent

Agelasines and agelasimines are antimicrobial and cytotoxic purine derivatives isolated from marine sponges (Agelas sp.). We have synthesized structurally simplified analogs of these natural products starting from β-cyclocitral. The novel compounds were found to be strong inhibitors of a wide variety of pathogenic microorganisms (incl. Mycobacterium tuberculosis) as well as cancer cell lines. The biological activities were generally in the same range as those previously found for the structurally more complex agelasines and agelasimines isolated in small amounts from natural sources. We also report for the first time that agelasine and agelasimine analogs inhibit growth of protozoa (Acanthamoeba castellanii and Acanthamoeba polyphaga). Acanthamoeba keratitis is an increasingly common and severe corneal infection, closely associated with contact lens wear.

Cyclohexenonic long-chain fatty alcohols as neuronal growth stimulators

Neurotrophic factors play an important role in the development and maintenance of neurons, thus providing a suitable therapeutic approach for the treatment of neurodegenerative diseases. However, their clinical use has revealed problematic because of a number of technical and biological disadvantages. Among the different strategies proposed to overcome such difficulties, the search for non-peptide substances with neurotrophic potential is giving promising results. Here we will expose major findings in this field, drawing special attention to cyclohexenonic long-chain fatty alcohols, a novel family of compounds that promote neuronal survival and neurite outgrowth.