566-61-0 Usage
Description
16-Allopregnenen-3beta-ol-20-one, also known as Allopregnenolone, is a neuroactive steroid derived from the metabolism of Progesterone. It possesses the ability to act as a positive allosteric modulator of the GABAA receptor, which plays a crucial role in the central nervous system. This steroid is not only present in the blood but also found in the brain, where it contributes to various physiological and neurological functions.
Uses
Used in Pharmaceutical Industry:
16-Allopregnen-3beta-ol-20-one is used as a pharmaceutical compound for its neuroactive properties. It is particularly valuable in the development of treatments for neurological disorders and conditions related to the central nervous system. Its ability to modulate the GABAA receptor makes it a promising candidate for therapeutic applications in anxiety, depression, and other mood-related disorders.
Used in Research Applications:
In the field of scientific research, 16-Allopregnen-3beta-ol-20-one serves as an essential tool for studying the role of neurosteroids in the brain and their interaction with the GABAA receptor. This steroid is used to investigate the underlying mechanisms of various neurological and psychiatric conditions, as well as to develop novel therapeutic strategies targeting the GABAergic system.
Used in Drug Development:
16-Allopregnen-3beta-ol-20-one is utilized in the development of new drugs targeting the GABAA receptor, which is involved in the regulation of neuronal excitability and the modulation of anxiety, stress, and sleep. Its role as a positive allosteric modulator makes it a potential lead compound for the creation of medications aimed at treating conditions such as epilepsy, insomnia, and anxiety disorders.
Used in Hormone Replacement Therapy:
As a metabolite of Progesterone, 16-Allopregnenolone is also considered for use in hormone replacement therapy, particularly for individuals experiencing hormonal imbalances or those undergoing menopause. Its neuroactive properties may help alleviate symptoms associated with hormonal changes, such as mood swings, anxiety, and sleep disturbances.
Check Digit Verification of cas no
The CAS Registry Mumber 566-61-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,6 and 6 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 566-61:
(5*5)+(4*6)+(3*6)+(2*6)+(1*1)=80
80 % 10 = 0
So 566-61-0 is a valid CAS Registry Number.
InChI:InChI=1/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h6,14-16,18-19,23H,4-5,7-12H2,1-3H3/t14-,15-,16-,18-,19-,20-,21+/m0/s1
566-61-0Relevant articles and documents
Grignard reagent induced tandem semipinacol rearrangement/ketone addition reaction of 20S-hydroxy-5α-pregnane-16(17)-epoxide
Huang, Chun-Xi,Shi, Yong,Lin, Jing-Rong,Jin, Rong-Hua,Tian, Wei-Sheng
supporting information; experimental part, p. 4123 - 4125 (2011/09/19)
A Grignard reagent induced tandem semipinacol rearrangement/chelation- controlled ketone addition process, which converts 20S-hydroxy-5α- pregnane-16(17)-epoxide into an unusual C20-substituted 17S-pregnane-3S,16R,20S- triol, is described.
