5638-76-6 Usage
Description
2-(2-METHYLAMINOETHYL)PYRIDINE is an organic compound with the chemical structure featuring a pyridine ring and a 2-(methylaminoethyl) side chain. It is known for its unique chemical properties and potential applications in various industries.
Uses
Used in Pharmaceutical Industry:
2-(2-METHYLAMINOETHYL)PYRIDINE is used as an intermediate compound for the synthesis of various pharmaceuticals. Its unique chemical structure allows it to be a key component in the development of new drugs targeting specific receptors or enzymes.
Used in Chemical Research:
In the field of chemical research, 2-(2-METHYLAMINOETHYL)PYRIDINE serves as a valuable building block for the creation of novel molecules with potential applications in various fields, such as materials science, medicinal chemistry, and biochemistry.
Used in Material Science:
2-(2-METHYLAMINOETHYL)PYRIDINE can be utilized as a component in the development of new materials with specific properties, such as improved conductivity, stability, or reactivity. Its incorporation into polymers or other materials can lead to enhanced performance in various applications.
Used in Analytical Chemistry:
As a compound with distinct chemical properties, 2-(2-METHYLAMINOETHYL)PYRIDINE can be employed as a reference material or standard in analytical chemistry for the calibration of instruments or the development of new analytical methods.
Indications
Betahistine is indicated in treatment of Meniere's disease (vertigo, hearing loss and tinnitus); it is not effective in preventing vertigo attacks.
Mechanism of action
The precise mechanism of betahistine's actions is unclear; it has antagonistic actions on histamine H3 receptors, and is a weak agonist at H receptors. In animal studies, it inhibits generation of spikes in vestibular nuclei. Its vasodilator activity (similar to histamine's) presumably improves blood flow in the inner ear and brainstem.
Pharmacokinetics
After oral administration, betahistine is rapidly and completely absorbed, rapidly metabolised (to one major metabolite, 2-pyridylacetic acid) and 90% excreted within 24 hours. Plasma and urinary half-lives are about 3.5 hours.
Side effects
Common adverse reactions include headache, nausea and dyspepsia. More rarely, hypersensitivity reactions (rash, pruritis, bronchospasm) and hypotension may occur.
Drug interactions
Co-administration of betahistine and monoamine oxidase inhibitors type B reduces metabolism of betahistine. Theoretically, interactions might occur with concurrent antihistamines; however, no significant problems have been reported.
Dosage forms
Betahistine is provided as scored tablets, 16 mg. Dose is 8-16 mg taken three times daily. It should be taken with food to minimise risk of GIT upsets. Patients are warned that it may take several weeks for beneficial effects to be noticed.
Precautions
Betahistine should be used with caution in individuals with asthma, urticaria, phaeochromocytoma or hypersensitivity to any components of tablets. Betahistine is contraindicated in people with active or history of peptic ulcer. Betahistine is classified in Pregnancy Safety Category B2: insufficient data available; it is contraindicated in pregnancy and lactation, and in children under 18.
Check Digit Verification of cas no
The CAS Registry Mumber 5638-76-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,6,3 and 8 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 5638-76:
(6*5)+(5*6)+(4*3)+(3*8)+(2*7)+(1*6)=116
116 % 10 = 6
So 5638-76-6 is a valid CAS Registry Number.
InChI:InChI=1S/C8H12N2/c1-9-7-5-8-4-2-3-6-10-8/h2-4,6,9H,5,7H2,1H3
5638-76-6Relevant articles and documents
Preparation method of betahistine
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Paragraph 0046-0052; 0067-0176;, (2021/09/29)
The invention discloses a preparation method of betahistine. The preparation method comprises the following steps: in the continuous flow reactor, 2 - vinylpyridine and methylamine salt solution are reacted to obtain the betahistine, and the preparation method is sufficient. Therein, 2 - vinylpyridine is not diluted or diluted with solvent and fed. The residence time of the reaction is not less 0.6 min. The reaction temperature is 100 - 250 °C. prepared by the method of the invention, the conversion rate of the raw material is high, the selectivity and yield of the product are high, the solvent residue is low, and the reaction time is short.
Selective synthesis of mono- and di-methylated amines using methanol and sodium azide as C1 and N1 sources
Chakrabarti, Kaushik,Mishra, Anju,Panja, Dibyajyoti,Paul, Bhaskar,Kundu, Sabuj
supporting information, p. 3339 - 3345 (2018/07/29)
A Ru(ii) complex mediated synthesis of various N,N-dimethyl and N-monomethyl amines from organic azides using methanol as a methylating agent is reported. This methodology was successfully applied for a one-pot reaction of bromide derivatives and sodium azide in methanol. Notably, by controlling the reaction time several N-monomethylated and N,N-dimethylated amines were synthesized selectively. The practical applicability of this tandem process was revealed by preparative scale reactions with different organic azides and synthesis of an anti-vertigo drug betahistine. Several kinetic experiments and DFT studies were carried out to understand the mechanism of this transformation.
The catalytic effect of anion-exchanged supported ionic liquid on aza-Michael-type addition
Ghasemi, Mohammad Hadi,Kowsari, Elaheh
, p. 3691 - 3709 (2017/06/20)
Abstract: An effective synthesis of anion-exchanged supported ionic liquids using diatomaceous earth as solid support and its catalytic effect on the aza-Michael-type addition is described. Anionic polytungstophosphate and bisulfate ion are used in the anion-exchange step in catalyst design. In addition, the aza-Michael-type addition of various amines to 2- and 4-vinyl pyridine was examined in this article. The catalytic system can be separated from the reaction mixture and recycled in subsequent reactions. The structure of anion-exchanged supported ionic liquid on diatomaceous earth was studied by XRD, FT-IR, SEM, TGA and BET techniques. The structure of organic products was determined by 1HNMR, 13CNMR, FTIR, CHN and MASS spectroscopy. Graphical Abstract: [Figure not available: see fulltext.].
