56290-53-0

Basic information

• Product Name: 1-(2-METHOXY-PHENYL)-BUTANE-1,3-DIONE
• Synonyms: 1-(2-METHOXY-PHENYL)-BUTANE-1,3-DIONE;1-(2-Methoxyphenyl)-1,3-butanedione
• CAS NO: 56290-53-0
• Molecular Formula: C₁₁H₁₂O₃
• Molecular Weight: 192.21
• Mol File: 56290-53-0.mol
• Article Data: 7

Chemical Properties

• Melting Point: 37 °C
• Boiling Point: 302.9°C at 760 mmHg
• Flash Point: 131.943°C
• Appearance: /
• Density: 1.098g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.509
• PKA: 9.08±0.23(Predicted)
• CAS DataBase Reference: 1-(2-METHOXY-PHENYL)-BUTANE-1,3-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-METHOXY-PHENYL)-BUTANE-1,3-DIONE(56290-53-0)
• EPA Substance Registry System: 1-(2-METHOXY-PHENYL)-BUTANE-1,3-DIONE(56290-53-0)

Safety Data

• Hazardous Substances Data: 56290-53-0(Hazardous Substances Data)

Usage

Description

1-(2-METHOXY-PHENYL)-BUTANE-1,3-DIONE, also known as dibenzoylmethane, is a chemical compound with the molecular formula C12H14O3. It is a diketone that is widely recognized for its ability to absorb and filter ultraviolet (UV) radiation, making it a valuable ingredient in the cosmetic and pharmaceutical industries.

Uses

Used in Cosmetic Industry:
1-(2-METHOXY-PHENYL)-BUTANE-1,3-DIONE is used as a UV filter for its ability to absorb and filter UV radiation, providing sun protection in sunscreen and other personal care products.
Used in Pharmaceutical Industry:
1-(2-METHOXY-PHENYL)-BUTANE-1,3-DIONE is used as an ingredient in pharmaceutical products due to its potential antioxidant and anti-inflammatory properties, which are currently being studied for their health effects and efficacy.

InChI:InChI=1/C11H12O3/c1-8(12)7-10(13)9-5-3-4-6-11(9)14-2/h3-6H,7H2,1-2H3

Upstream product

• 579-74-8 2-Methoxyacetophenone 
• 141-78-6 ethyl acetate 
• 578-57-4 2-bromoanisole 
• 529-28-2 4-iodoanisol 
• 201230-82-2 carbon monoxide 
• 67-64-1 acetone 
• 21615-34-9 2-Methoxybenzoyl chloride 
• 606-45-1 2-methoxybenzoic acid methyl ester 

Downstream Products

• 81450-25-1 2-hydroxy-2'-carboxydeoxybenzoin 
• 143882-36-4 3-(2-hydroxy-phenyl)-2H-isoquinolin-1-one 
• 143882-37-5 2-Ethyl-3-(2-hydroxyphenyl)isoquinolin-1(2H)-one 
• 143882-38-6 3-(2-Hydroxyphenyl)-2-phenylisoquinolin-1(2H)-one 
• 1733-52-4 1-(diphenylphosphinoyl)propan-2-one 
• 56945-03-0 2-(1,3-dithiolan-2-ylidene)-1-(2-methoxyphenyl)ethanone 
• 5751-48-4 2-methylchromone 
• 1210068-78-2 C₂₃H₂₂O₁₀ 
• 1210068-92-0 C₂₃H₂₂O₁₀ 
• 1135793-47-3 3-[(2,2-dimethoxyethyl)amino]-1-(2-methoxyphenyl)but-2-en-1-one 

Relevant articles and documents

I2-Promoted [3+2] Cyclization of 1,3-Diketones with Potassium Thiocyanate: a Route to Thiazol-2(3H)-One Derivatives

An I2-promoted strategy has been developed for the synthesis of thiazol-2(3H)-one derivatives from 1,3-diketones with potassium thiocyanate. This [3+2] cyclization reaction involves C?S and C?N bond formation and exhibits good functional group tolerance. A series of thiazol-2(3H)-one derivatives are obtained in moderate to good yields. (Figure presented.).

Discovery and structure-activity relationships study of novel thieno[2,3-b]pyridine analogues as hepatitis C virus inhibitors

Current treatment for hepatitis C is barely satisfactory, there is an urgent need to develop novel agents for combating hepatitis C virus infection. This study discovered a new class of thieno[2,3-b]pyridine derivatives as HCV inhibitors. First, a hit compound characterized by a thienopyridine core was identified in a cell-based screening of our privileged small molecule library. And then, structure activity relationship study of the hit compound led to the discovery of several potent compounds without obvious cytotoxicity in vitro (12c, EC50 = 3.3 μM, SI >30.3, 12b, EC50 = 3.5 μM, SI >28.6, 10l, EC50 = 3.9 μM, SI >25.6, 12o, EC 50 = 4.5 μM, SI >22.2, respectively). Although the mechanism of them had not been clearly elucidated, our preliminary optimization of this class of compounds had provided us a start point to develop new anti-HCV agents.

Palladium-catalysed carbonylative α-arylation of acetone and acetophenones to 1,3-diketones

Three COmponent α-arylation: A carbonylative ketone α-arylation process employing acetone for the first time, as well as acetophenones, is described (see scheme). The reaction tolerates a range of (hetero)aryl iodides and several functionalised aryl ketone coupling partners. Only low pressures of molecular CO are applied and no additional solvent is necessary. Copyright