55934-22-0

Basic information

• Product Name: 2,4-DICHLORO-7-METHOXY QUINOLINE
• Synonyms: 2,4-DICHLORO-7-METHOXY QUINOLINE
• CAS NO: 55934-22-0
• Molecular Formula: C₁₀H₇Cl₂NO
• Molecular Weight: 228.077
• Mol File: 55934-22-0.mol
• Article Data: 9

Chemical Properties

• Melting Point: 132-133 °C(Solv: ethanol (64-17-5))
• Boiling Point: 327.9 °C at 760 mmHg
• Flash Point: 152.1 °C
• Appearance: /
• Density: 1.384 g/cm³
• Vapor Pressure: 0.000374mmHg at 25°C
• Refractive Index: 1.63
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -0.79±0.50(Predicted)
• CAS DataBase Reference: 2,4-DICHLORO-7-METHOXY QUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DICHLORO-7-METHOXY QUINOLINE(55934-22-0)
• EPA Substance Registry System: 2,4-DICHLORO-7-METHOXY QUINOLINE(55934-22-0)

Safety Data

• Hazardous Substances Data: 55934-22-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,4-Dichloro-7-methoxy quinoline is used as an intermediate in the synthesis of various pharmaceuticals for its unique chemical properties and structural diversity. It plays a crucial role in the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, 2,4-Dichloro-7-methoxy quinoline is utilized as a key component in the production of certain agrochemicals. Its unique properties contribute to the effectiveness and performance of these products in agricultural applications.
Used in Organic Materials:
2,4-Dichloro-7-methoxy quinoline is employed in the development of organic materials due to its chemical properties and structural characteristics. It serves as a building block in the creation of new compounds with potential applications in various fields.
Used in Chemical Research:
As a valuable building block in chemical research, 2,4-Dichloro-7-methoxy quinoline is used for the development of new compounds with a range of potential applications. Its unique properties and structural diversity make it a promising candidate for further exploration and innovation in the field of chemistry.

InChI:InChI=1/C10H7Cl2NO/c1-14-6-2-3-7-8(11)5-10(12)13-9(7)4-6/h2-5H,1H3

Upstream product

• 141-82-2 malonic acid 
• 536-90-3 m-Anisidine 
• 27037-34-9 4-hydroxy-7-methoxy-2-oxo-1,2-dihydroquinoline 
• 855765-21-8 4-hydroxy-5-methoxyquinoline-2(1H)-one 
• 68050-20-4 4-chloro-7-methoxy-quinolin-2-ylamine 
• 99071-95-1 2-amino-7-methoxy-quinolin-4-ol 
• 99074-22-3 4-chloro-7-methoxy-quinolin-2-ol 

Downstream Products

• 1409964-05-1 4-chloro-2-(4-isopropoxyphenyl)-7-methoxyquinoline 

Relevant articles and documents

Hepatitis C virus inhibitors

Hepatitis C virus inhibitors having the general formula (I) are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

5-Methoxyquinoline derivatives as a new class of EZH2 inhibitors

A series of quinoline derivatives was synthesized and biologically evaluated as Enhancer of Zeste Homologue 2 (EZH2) inhibitors. Structure-activity relationship (SAR) studies led to the discovery of 5-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinolin-4-amine (5k), which displayed an IC50 value of 1.2 μM against EZH2, decreased global H3K27me3 level in cells and also showed good anti-viability activities against two tumor cell lines. Due to the low molecular weight and the fact that no quinoline derivative has been reported as an EZH2 inhibitor, this compound could serve as a lead compound for further optimization.

Syntheses and fluorescent properties of 6-methoxy-2-oxoquinoline-3,4- dicarbonitriles and 6,7-dimethoxy-2-oxoquinoline-3,4-dicarbonitriles

4-Chlorocarbostyrils 3, 12, 17, 24, 26 with methoxy substituents in 6, 7, or 6,7-position react with potassium cyanide in a p-toluenesulfinate mediated reaction either to the highly fluorescent and stable 2-oxoquinoline-3,4- dicarbonitriles 6, 27, 29, 30 or at slightly lower temperatures to 4-monocarbonitriles 5, 13, 18. 4-Chlorocarbostyril 3 and lithium p-toluenesulfinate gave pure 4-toluenesulfonylquinolone 4, which reacted with potassium cyanide either to monocarbonitrile 5 or dicarbonitrile 6, depending on the reaction conditions. 4-Trifluoromethylquinolones 9 and 19 were prepared for fluorescence comparison from the appropriate methoxyaniline and 4,4,4-trifluoroacetoacetate. The fluorescence properties such as emission wavelengths and quantum yields of 6-methoxyderivatives 4, 5, 6, 9, 13 were studied and compared with those of 7-methoxy derivatives 18, 19 and 6,7-dimethoxyderivatives 27, 28, 29, 30. 6,7-Dimethoxy derivatives show best results, showing long-waved fluorescence spectra up to 520 nm and acceptable quantum yields up to 0.46 for 3,4-dicyano derivative 27 excited at 440 nm in acetonitrile.

Hepatitis C Virus Inhibitors

Hepatitis C virus inhibitors having the general formula (I) are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

STEREOSELECTIVE METHODS, CATALYSTS AND INTERMEDIATES FOR THE SYNTHESIS OF (-)-NUTLIN-3 AND RELATED COMPOUNDS

The present invention provides methods and intermediates are provided for the preparation of (?)-Nutlin-3. Methods and intermediates are also provided for the enantioselective addition of aryl nitromethanes to aldimines. Bis(amidine) catalysts for the use

PROCESS FOR PREPARING BROMO-SUBSTITUTED QUINOLINES

Disclosed are methods for the preparation of bromo-substituted quinolines of the formula (I) where R is aryl, heteroaryl, alkyl, alkenyl or alkynyl, which are useful as intermediates in the preparation of agents for the treatment of hepatitis C viral (HCV) infections: Formula (I).

HCV INHIBITORS

The present invention is directed to compounds that are antiviral agents. Specifically the compounds of the present invention inhibit replication of HCV and are therefore useful in treating hepatitis C infections. The present invention is also directed to pharmaceutical compositions comprising these compounds and processes for preparing them.

A convenient synthesis of 8,9,10,11-tetrahydrodibenzo[b,h] [1,6]naphthyridin-6(5H)ones

Substituted 8,9,10,11-tetrahydrodibenzo[b,h][1,6]naphthyridin-6(5H)ones (5) have been synthesized by the condensation of 4-amino-3-formylquinolin-2(1H)ones (4) with cyclohexanone in presence of acetic acid and sulphuric acid. The precusors have been obtained by the animation of 4-chloro-3-formylquinolin-2(1H)ones (3).

2,4-Dihalogenoquinolines. Synthesis, Orientation Effects and 1H and 13C NMR Spectral Studies

Isomer ratios for the syntheses of 2,4-dichloroquinolines from meta-substituted and 3,4-disubstituted anilines are reported, a synthesis of 2,4-dibromoquinoline 1b is also described.The structures of certain bromination products 17 and 1f obtained from 4-hydroxy-2-quinolone have been revised.A thorough study of the 1H and 13C NMR spectra of a series of 2,4-dihalogenoquinolines is presented and the effects of the halogen substituents on JCH couplings are highlighted.