557-61-9Relevant articles and documents
Synthesis of long-chain fatty acid derivatives as a novel anti-Alzheimer's agent
Zhang, Hong-Yan,Yamakawa, Yu-Ichiro,Matsuya, Yuji,Toyooka, Naoki,Tohda, Chihiro,Awale, Suresh,Li, Feng,Kadota, Shigetoshi,Tezuka, Yasuhiro
, p. 604 - 608 (2014/01/23)
In order to develop new drugs for Alzheimer's disease, we prepared 17 fatty acid derivatives with different chain lengths and different numbers and positions of double bonds by using Wittig reaction and stereospecific hydrogenation of triple bonds as key reactions. Among them, (4Z,15Z)- octadecadienoic acid (10) and (23Z,34Z)-heptatriacontadienoic acid (16) showed the most potent neurite outgrowth activities on Aβ(25-35)-treated rat cortical neurons, which activities were comparable to that of a positive control, NGF. Both fatty acids 10 and 16 possess two (Z)-double bonds at the n-3 and n-14 positions, which might be important for the neurite outgrowth activity.
PROCESS FOR THE PREPARATION OF ALIPHATIC PRIMARY ALCOHOLS AND RELATED INTERMEDIATES IN SUCH PROCESS
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Page/Page column 13-14, (2010/11/08)
The invention relates to a new method prepare high-molecular-weight aliphatic linear, straight-chain primary alcohols having between 24 up to and including 32 carbon atoms, comprising the steps of : a. transforming the alcohol group of an α-functionalised-ω-hydroxy linear straight chain alkyl or alkene (i) into an alkoxy-metal complex (ii) b. optionally, followed by a transformation of the α-group into a nucleophilic group, c. followed by a coupling reaction of the component as formed on its α-position. The invention further relates to process for the preparation of such protected alcohols via an organometallic cross coupling reaction or a Wittig reaction and novel intermediates and starting compounds therefore.
PROCESS FOR THE PREPARATION OF ALIPHATIC PRIMARY ALCOHOLS AND RELATED INTERMEDIATES IN SUCH PROCESS
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Page/Page column 9; 13, (2010/02/11)
The invention relates to protected alcohol with formula (R1 - O-)mPG, wherein R1 represents a linear, straight-chain alkyl group having 26-30 C-atoms, m is 1 or 2, and PG, forming an ether group in combination with the -O- of the former primary alcohol, represents a protecting group chosen from the group of substituted methyl, substituted ethyl, substituted benzyl and (substituted) silyl groups with at least one substituent on the Si-atom being not a methyl group, in case m = 1; and a diol protecting group in case m = 2, with the proviso that PG is no saccharide. The invention further relates to process for the preparation of such protected alcohols via an organometallic cross coupling reaction.