55279-30-6

Basic information

• Product Name: 3-AMINO-ISONICOTINIC ACID METHYL ESTER
• Synonyms: METHYL 3-AMINOPYRIDINE-4-CARBOXYLATE;METHYL 3-AMINOISONICOTINATE;AKOS 93360;3-AMINO-ISONICOTINIC ACID METHYL ESTER;3-AMINO-4-PYRIDINECARBOXYLIC ACID METHYL ESTER;3-AMINOPYRIDINE-4-CARBOXYLIC ACID METHYL ESTER;3-Amino-isonicotinic acid methyl ester ,98%;Tpc-py003
• CAS NO: 55279-30-6
• Molecular Formula: C₇H₈N₂O₂
• Molecular Weight: 152.15
• EINECS: 1592732-453-0
• Product Categories: pharmacetical;Esters;Pyridines;Pyridine
• Mol File: 55279-30-6.mol
• Article Data: 14

Chemical Properties

• Melting Point: 84-86
• Boiling Point: 292.5 ºC at 760 mmHg
• Flash Point: 130.7 ºC
• Appearance: /
• Density: 1.238 g/cm³
• Vapor Pressure: 0.00183mmHg at 25°C
• Refractive Index: 1.57
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 4.05±0.18(Predicted)
• CAS DataBase Reference: 3-AMINO-ISONICOTINIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-ISONICOTINIC ACID METHYL ESTER(55279-30-6)
• EPA Substance Registry System: 3-AMINO-ISONICOTINIC ACID METHYL ESTER(55279-30-6)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-36/38
• Safety Statements: 24/25
• Hazardous Substances Data: 55279-30-6(Hazardous Substances Data)

Usage

Chemical Properties

Yellow powder

Uses

3-Aminoisonicotinic Acid Methyl Ester is a useful synthetic intermediate. It is used in the synthesis of morpholinophenylquinazolines and related derivatives as PI3 kinase p110α inhibitors. It is also used to synthesize aryl tetrahydropyridine inhibitors of farnesyltransferase as antitumor agents.

InChI:InChI=1/C7H8N2O2/c1-11-7(10)5-2-3-9-4-6(5)8/h2-4H,8H2,1H3

Upstream product

• 179024-65-8 3-tert-butoxycarbonylaminoisonicotinic acid 
• 56700-70-0 3-(tert-butoxycarbonylamino)pyridine 
• 462-08-8 pyridin-3-ylamine 
• 7579-20-6 3-Aminopyridine-4-carboxylic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 67-56-1 methanol 
• 103698-10-8 methyl 3-nitropyridine-4-carboxylate 
• 55-22-1 pyridine-4-carboxylic acid 
• 4664-01-1 3,4-pyridinedicarboximide 
• 158062-71-6 4-trifluoromethyl-3-pyridinecarboxamide 
• 158063-66-2 4-(trifluoromethyl)nicotinic acid 
• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 

Downstream Products

• 188677-49-8 methyl 3-iodo-4-pyridinecarboxylate 
• 883107-62-8 2,6-dichloro-3-amino-4-pyridinecarboxylic acid methyl ester 
• 1352037-95-6 3-phenyl-2-(pyridin-4-yl)-1,7-naphthyridine 
• 55279-29-3 3-amino-pyridine-4-carbaldehyde 
• 58484-01-8 3-amino-2,6-dichloroisonicotinic acid 
• 153716-51-9 3-(1-pyrrolyl)-pyridine-4-carboxylic acid 
• 570397-03-4 4-(1-methoxycarbonyl-3-methylsulfanyl-propylcarbamoyl)-5-o-tolyl-3,6-dihydro-2H-pyridine-1-carboxylic acid 3-cyclohexyl-1-thiazol-5-yl-propyl ester 
• 355008-64-9 2-{[1-(benzyl-thiazol-5-ylmethyl-carbamoyl)-5-o-tolyl-1,2,3,6-tetrahydro-pyridine-4-carbonyl]-amino}-4-methylsulfanyl-butyric acid methyl ester 
• 355008-59-2 4-(1-methoxycarbonyl-3-methylsulfanyl-propylcarbamoyl)-5-o-tolyl-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 355008-58-1 1-(1',1'-dimethylethoxycarbonyl)-3-(2-methylphenyl)-1,2,5,6-tetrahydroisonicotinic acid 
• 355008-56-9 1-benzyl-3-(2-methylphenyl)-1,2,5,6-tetrahydroisonicotinic acid, methyl ester 
• 355008-55-8 methyl 3-(o-tolyl)isonicotinate 
• 371948-82-2 3-(4-oxo-3,4-dihydropyrido[3,4-d]pyrimidin-2-yl)phenyl acetate 
• 371948-60-6 3-(3-methoxy-benzoylamino)-isonicotinamide 

Relevant articles and documents

Synthesis method of 3-amino methyl isonicotinate

The invention discloses a synthesis method of 3-amino methyl isonicotinate, wherein the synthesis method comprises the steps: by taking 4-trifluoromethyl nicotinic acid as an initial raw material, sequentially carrying out acylation condensation series connection, Hofmann degradation, hydrolysis and esterification reaction to obtain the 3-amino methyl isonicotinate. The synthesis method has the advantages of mild reaction conditions, high yield, low cost, easily available raw materials, and realization of industrial production, the thionyl chloride reaction liquid can be repeatedly used, the utilization rate of the raw materials is improved, the resource waste is reduced, the pollution is reduced, the production cost of the whole process is furthest reduced, and the application value is extremely high.

Method for rapidly and efficiently synthesizing 3-aminoisonicotinic acid methyl ester (by machine translation)

Of the method for rapidly and efficiently synthesizing 3 - aminoisonicotinic acid methyl ester, through nitration, reduction, to obtain the 3 -aminoisonicotinic acid methyl ester, disclosed by the invention can be repeatedly utilized 3 - to improve the utilization rate, of the raw material and reduce the resource waste, to the maximum reduction . of the whole process . The method comprises the following steps: synthesizing,aminoisonicotinic acid methyl ester in a high, total yield; and reducing resource waste. (by machine translation)

Hofmann-type rearrangement of imides by in situ generation of imide-hypervalent iodines(III) from iodoarenes

The Hofmann-type rearrangement of aromatic and aliphatic imides using a hypervalent iodine(III) reagent generated in situ from PhI, m-CPBA, and TsOH·H2O proceeded in the presence of a base in alcohol to provide anthranilic acid derivatives and amino acid derivatives in high yields, respectively. This reaction proceeds through a tandem reaction via alcoholysis followed by a Hofmann rearrangement promoted by the formation of an imide-λ3-iodane intermediate.