55279-30-6

Basic information

• Product Name: 3-AMINO-ISONICOTINIC ACID METHYL ESTER
• Synonyms: METHYL 3-AMINOPYRIDINE-4-CARBOXYLATE;METHYL 3-AMINOISONICOTINATE;AKOS 93360;3-AMINO-ISONICOTINIC ACID METHYL ESTER;3-AMINO-4-PYRIDINECARBOXYLIC ACID METHYL ESTER;3-AMINOPYRIDINE-4-CARBOXYLIC ACID METHYL ESTER;3-Amino-isonicotinic acid methyl ester ,98%;Tpc-py003
• CAS NO: 55279-30-6
• Molecular Formula: C₇H₈N₂O₂
• Molecular Weight: 152.15
• EINECS: 1592732-453-0
• Product Categories: pharmacetical;Esters;Pyridines;Pyridine
• Mol File: 55279-30-6.mol
• Article Data: 14

Chemical Properties

• Melting Point: 84-86
• Boiling Point: 292.5 ºC at 760 mmHg
• Flash Point: 130.7 ºC
• Appearance: /
• Density: 1.238 g/cm³
• Vapor Pressure: 0.00183mmHg at 25°C
• Refractive Index: 1.57
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 4.05±0.18(Predicted)
• CAS DataBase Reference: 3-AMINO-ISONICOTINIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-ISONICOTINIC ACID METHYL ESTER(55279-30-6)
• EPA Substance Registry System: 3-AMINO-ISONICOTINIC ACID METHYL ESTER(55279-30-6)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-36/38
• Safety Statements: 24/25
• Hazardous Substances Data: 55279-30-6(Hazardous Substances Data)

Usage

Chemical Properties

Yellow powder

Uses

3-Aminoisonicotinic Acid Methyl Ester is a useful synthetic intermediate. It is used in the synthesis of morpholinophenylquinazolines and related derivatives as PI3 kinase p110α inhibitors. It is also used to synthesize aryl tetrahydropyridine inhibitors of farnesyltransferase as antitumor agents.

InChI:InChI=1/C7H8N2O2/c1-11-7(10)5-2-3-9-4-6(5)8/h2-4H,8H2,1H3

Upstream product

• 103698-10-8 methyl 3-nitropyridine-4-carboxylate 
• 67-56-1 methanol 
• 7579-20-6 3-Aminopyridine-4-carboxylic acid 
• 158062-71-6 4-trifluoromethyl-3-pyridinecarboxamide 
• 158063-66-2 4-(trifluoromethyl)nicotinic acid 
• 55-22-1 pyridine-4-carboxylic acid 
• 179024-65-8 3-tert-butoxycarbonylaminoisonicotinic acid 
• 56700-70-0 3-(tert-butoxycarbonylamino)pyridine 
• 462-08-8 pyridin-3-ylamine 
• 4664-01-1 3,4-pyridinedicarboximide 
• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 
• 18107-18-1 diazomethyl-trimethyl-silane 

Downstream Products

• 188677-49-8 methyl 3-iodo-4-pyridinecarboxylate 
• 883107-62-8 2,6-dichloro-3-amino-4-pyridinecarboxylic acid methyl ester 
• 1352037-95-6 3-phenyl-2-(pyridin-4-yl)-1,7-naphthyridine 
• 55279-29-3 3-amino-pyridine-4-carbaldehyde 
• 58484-01-8 3-amino-2,6-dichloroisonicotinic acid 
• 54920-76-2 [1,7]naphthyridine-2,4-diol 

Relevant articles and documents

Synthesis method of 3-amino methyl isonicotinate

The invention discloses a synthesis method of 3-amino methyl isonicotinate, wherein the synthesis method comprises the steps: by taking 4-trifluoromethyl nicotinic acid as an initial raw material, sequentially carrying out acylation condensation series connection, Hofmann degradation, hydrolysis and esterification reaction to obtain the 3-amino methyl isonicotinate. The synthesis method has the advantages of mild reaction conditions, high yield, low cost, easily available raw materials, and realization of industrial production, the thionyl chloride reaction liquid can be repeatedly used, the utilization rate of the raw materials is improved, the resource waste is reduced, the pollution is reduced, the production cost of the whole process is furthest reduced, and the application value is extremely high.

Method for rapidly and efficiently synthesizing 3-aminoisonicotinic acid methyl ester (by machine translation)

Of the method for rapidly and efficiently synthesizing 3 - aminoisonicotinic acid methyl ester, through nitration, reduction, to obtain the 3 -aminoisonicotinic acid methyl ester, disclosed by the invention can be repeatedly utilized 3 - to improve the utilization rate, of the raw material and reduce the resource waste, to the maximum reduction . of the whole process . The method comprises the following steps: synthesizing,aminoisonicotinic acid methyl ester in a high, total yield; and reducing resource waste. (by machine translation)

High-yield synthesis method of methyl 3-aminoisonicotinate

The invention belongs to the field of chemical pharmacy, and particularly discloses a high-yield synthesis method of methyl 3-aminoisonicotinate. According to the high-yield synthesis method, 4-picolinic acid is used as a raw material and subjected to brominating, ammonifying and esterifying to obtain methyl 3-aminoisonicotinate. The high-yield synthesis method of methyl 3-aminoisonicotinate has the advantages of mild reaction conditions, high total yield, realization of repeated use of a 3-bromo-4-picolinic acid reaction waste filtrate, improvement of the utilization rate of the raw material,reduction of resource waste, maximum reduction of the production cost of the whole process, and extremely high application value.

Azaindole synthesis through dual activation catalysis with N-heterocyclic carbenes

A convergent, transition-metal-free synthesis of 2-aryl-azaindoles has been developed. The interception of a reactive aza-ortho-azaquinone methide intermediate by an acyl anion equivalent generated through carbene catalysis provides high yields, a wide substrate scope, and the synthesis of previously inaccessible azaindoles.

Hofmann-type rearrangement of imides by in situ generation of imide-hypervalent iodines(III) from iodoarenes

The Hofmann-type rearrangement of aromatic and aliphatic imides using a hypervalent iodine(III) reagent generated in situ from PhI, m-CPBA, and TsOH·H2O proceeded in the presence of a base in alcohol to provide anthranilic acid derivatives and amino acid derivatives in high yields, respectively. This reaction proceeds through a tandem reaction via alcoholysis followed by a Hofmann rearrangement promoted by the formation of an imide-λ3-iodane intermediate.

Synthesis of novel 1,7-naphthyridines by Friedlaender condensation of pyridine substrates

The general ability of appropriate pyridyl compounds (aldehyde or ketone) to undergo Friedlaender condensation to give different 1,7-naphthyridines has been demonstrated. 2,4-Disubstituted 1,7-naphthyridine 8 was prepared from 3-amino-4-acetylpyridine (6) and ketone 4 (82%). The Friedlaender self-condensation of pyridyl substrate 6 is reported, as well. The dimer product, 2-(3-aminopyridin-4-yl)-4-methyl-1,7-naphthyridine (7), was obtained in 97% yield. 2-Aryl-and 2,3-diaryl-1,7-naphthyridines (16-18) were prepared from 3-aminoisonicotinaldehyde (13) and arylketones 4, 14, and 15 (28-71%). The key substrates 6 and 13 are readily available via the improved pyridine nitration method. Copyright

Iminooxazolidine Derivatives and Their Use

The present application relates to novel iminooxazolidine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular thromboembolic disorders.

HETEROCYCLIC HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME

A hydrazide compound represented by the formula (I), an N-oxide thereof or suitable salt thereof: has excellent pesticidal activity.

BICYCLIC PYRIMIDIN-4-(3H)-ONES AND ANALOGUES AND DERIVATIVES THEREOF WHICH MODULATE THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1)

Compounds of formula (I); which are useful as therapeutic compounds, particularly in the treatment of pain and other conditions ameliorated by the modulation of the function of the vanilloid-1 receptor (VR1).