54839-12-2

Basic information

• Product Name: 1-(4-chlorophenyl)-2-cyclopropylethanone
• Synonyms: 1-(4-chlorophenyl)-2-cyclopropylethanone;Ethanone, 1-(4-chlorophenyl)-2-cyclopropyl-;1-(4-chlorophenyl)-2-cyclopropylethanone(WXC05048)
• CAS NO: 54839-12-2
• Molecular Formula: C₁₁H₁₁ClO
• Molecular Weight: 194.65744
• Mol File: 54839-12-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 302.8 °C at 760 mmHg
• Flash Point: 154.2 °C
• Appearance: /
• Density: 1.2 g/cm³
• CAS DataBase Reference: 1-(4-chlorophenyl)-2-cyclopropylethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-chlorophenyl)-2-cyclopropylethanone(54839-12-2)
• EPA Substance Registry System: 1-(4-chlorophenyl)-2-cyclopropylethanone(54839-12-2)

Safety Data

• Hazardous Substances Data: 54839-12-2(Hazardous Substances Data)

Usage

General Description

1-(4-chlorophenyl)-2-cyclopropylethanone, also known as cicloprofen, is a chemical compound with the molecular formula C11H11ClO. It is a synthetic organic compound that belongs to the class of cyclopropyl ketones, which are known for their potential application as pharmaceutical agents. This specific compound has a cyclopropyl group and a chlorophenyl group attached to a ketone functional group. It is used primarily as a precursor in the synthesis of various pharmaceuticals and agrochemicals due to its potential as a pharmacophore for the development of new drugs. However, it is important to handle and use this chemical with caution and in accordance with proper safety protocols due to its potential health hazards and toxicity.

Upstream product

• 6542-60-5 2-cyclopropylacetonitrile 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 79-37-8 oxalyl dichloride 
• 67-68-5 dimethyl sulfoxide 

Downstream Products

• 123989-29-7 1-(p-chlorophenyl)-2-cyclopropyl-2-methylethan-1-one 

Relevant articles and documents

Discovery of the Oxadiazine FRM-024: A Potent CNS-Penetrant Gamma Secretase Modulator

The recent approval of aducanumab for Alzheimer's disease has heightened the interest in therapies targeting the amyloid hypothesis. Our research has focused on identification of novel compounds to improve amyloid processing by modulating gamma secretase activity, thereby addressing a significant biological deficit known to plague the familial form of the disease. Herein, we describe the design, synthesis, and optimization of new gamma secretase modulators (GSMs) based on previously reported oxadiazine 1. Potency improvements with a focus on predicted and measured properties afforded high-quality compounds further differentiated via robust Aβ42 reductions in both rodents and nonhuman primates. Extensive preclinical profiling, efficacy studies, and safety studies resulted in the nomination of FRM-024, (+)-cis-5-(4-chlorophenyl)-6-cyclopropyl-3-(6-methoxy-5-(4-methyl-1H-imidazole-1-yl)pyridin-2-yl)-5,6-dihydro-4H-1,2,4-oxadiazine, as a GSM preclinical candidate for familial Alzheimer's disease.

ANTIFUNGAL 1,2,4-TRIAZOLYL DERIVATIVES HAVING A 5- SULFUR SUBSTITUENT

The present invention relates to novel triazole compounds of the formulae (I) and (Il) as defined below, to agricultural and pharmaceutical compositions containing them and to their use as fungicides antiviral and anticancer agents.

α-phenyl- or benzyl-α-cyclopropylalkylene-1H-imidazole- and 1,2,4-triazole-1-ethanols and use against fungus

The invention provides novel α-aryl- or -aralkyl-α-(cycloalkyl-alkyl)-1H-azole-1-ethanols, in which the alkyl moiety linking the cycloalkyl group to the ethanol group is substituted or branched at the carbon atom adjacent to the C(OH) group, which are use