538-49-8

Basic information

• Product Name: 2-(2-Phenethenyl)pyridine
• Synonyms: (E)-2-Stilbazole;2-[(E)-2-Phenylvinyl]pyridine;2-[(E)-Styryl]pyridine;2-trans-Styrylpyridine
• CAS NO: 538-49-8
• Molecular Formula: C₁₃H₁₁N
• Molecular Weight: 181.23
• EINECS: 211-934-5
• Mol File: 538-49-8.mol
• Article Data: 138

Chemical Properties

• Melting Point: 91.5°C
• Boiling Point: 304.35°C (rough estimate)
• Flash Point: 127.2°C
• Appearance: /
• Density: 1.0147
• Vapor Pressure: 0.00196mmHg at 25°C
• Refractive Index: 1.6118 (estimate)
• CAS DataBase Reference: 2-(2-Phenethenyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-Phenethenyl)pyridine(538-49-8)
• EPA Substance Registry System: 2-(2-Phenethenyl)pyridine(538-49-8)

Safety Data

• Hazardous Substances Data: 538-49-8(Hazardous Substances Data)

Usage

Description

2-(2-Phenethenyl)pyridine, with the chemical formula C14H13N, is a colorless to light yellow liquid characterized by a strong, floral scent. This chemical compound serves as a versatile intermediate in organic synthesis, particularly for the preparation of pyridine derivatives, and is integral to the production of pharmaceuticals, flavoring agents, and fragrance ingredients.

Uses

Used in Pharmaceutical Industry:
2-(2-Phenethenyl)pyridine is utilized as an active pharmaceutical ingredient for the development of various medications, leveraging its unique chemical properties to enhance therapeutic effects and improve patient outcomes.
Used in Flavor and Fragrance Industry:
As a flavoring agent, 2-(2-Phenethenyl)pyridine is employed to impart distinctive, floral notes to food products, contributing to the overall sensory experience of consumption.
Used in Fragrance Industry:
In the realm of fragrances, 2-(2-Phenethenyl)pyridine serves as a key ingredient to create complex and appealing scents for perfumes, colognes, and other personal care products, capitalizing on its strong floral aroma.
Used in Organic Synthesis:
2-(2-Phenethenyl)pyridine is used as a crucial intermediate in organic synthesis, particularly for the preparation of pyridine derivatives, which are essential components in a wide range of chemical and pharmaceutical applications.
Safety Considerations:
While 2-(2-Phenethenyl)pyridine is relatively stable under normal conditions, it is important to handle and store it with care to avoid potential irritation to the skin, eyes, and respiratory system. Proper safety measures should be implemented during its use to minimize health risks.

InChI:InChI=1/C13H11N/c1-2-6-12(7-3-1)9-10-13-8-4-5-11-14-13/h1-11H/b10-9+

Upstream product

• 109-06-8 α-picoline 
• 100-52-7 benzaldehyde 
• 6294-62-8 2-stilbazole dibromide 
• 120240-99-5 2-pyridyl styryl sulfoxide 
• 38700-15-1 triphenyl-(2-pyridylmethyl)phosphonium chloride 
• 1121-60-4 pyridine-2-carbaldehyde 
• 109-09-1 2-chloropyridine 
• 100-42-5 styrene 
• 100-39-0 benzyl bromide 
• 1449-46-3 benzyltriphenylphosphonium bromide 
• 2294-74-8 1-phenyl-2-pyridin-2-yl-ethanol 
• 2637-34-5 pyridine-2-thione 
• 6783-05-7 trans-2-phenylvinylboronic acid 
• 109-04-6 2-bromo-pyridine 

Downstream Products

• 1121-60-4 pyridine-2-carbaldehyde 
• 13474-48-1 1-phenyl-2-pyridin-2-yl-ethane-1,2-dione 
• 17152-06-6 2-(benzo[b]selenophen-2-yl)pyridine 
• 132363-97-4 2-(2-phenylethyl)piperidine 
• 70779-18-9 6-benzhydryl-3,3,4-triphenyl-5-pyridin-2-yl-3,4-dihydro-pyran-2-one 
• 60601-60-7 2-(2-cyclohexylethyl)-piperidine hydrochloride 
• 98-98-6 2-Picolinic acid 
• 65-85-0 benzoic acid 
• 100-52-7 benzaldehyde 
• 6294-62-8 2-stilbazole dibromide 
• 13141-42-9 2-(2-phenylethynyl)pyridine 
• 2116-62-3 2-(2-phenylethyl)pyridine 
• 1627500-41-7 C₂₂H₁₆F₅NO 
• 2294-74-8 (-)-1-phenyl-2-(α-pyridyl)ethanol 

Relevant articles and documents

X-ray crystal structure of 2-styrylpyridine

We have crystallized the 2-styrylpyridine from the condensation reaction between the 2-methylpyridine with benzaldehyde in the formation of the model compound 2-styrylpyridine. The X-ray structure and NMR are currently reported. The main features of the structure is that it shows a localization of the double bonds rather than a delocalization of π electrons in an aromatic fashion.

A new insight into the push-pull effect of substituents via the stilbene-like model compounds

In this paper, authors report on 1-pyridyl-2-arylethenes, 1-furyl-2-arylethylenes, 1,2-diphenylpropylenes and substituted cinnamyl anilines as stilbene-like model compounds to investigate the factors dominating the push-pull effect of substituents via usi

Preparation method of alkyl/alkenyl substituted nitrogen-containing heterocyclic compound

The invention belongs to the technical field of organic synthesis, and particularly discloses a preparation method of an alkyl/alkenyl substituted nitrogen-containing heterocyclic compound, which comprises the following steps: (1) adding a 2-methyl nitrogen-containing heterocyclic compound, primary alcohol, alkali and an additive into an organic solvent, performing stirring reaction for 24 hours, and then cooling the product to room temperature; and (2) concentrating, separating and purifying the reaction liquid obtained in the step (1). The simple and effective method for preparing the alkyl/alkenyl substituted nitrogen-containing heterocyclic compound under the metal-free and ligand-free conditions is realized, the 2-methyl nitrogen-containing heterocyclic compound and the primary alcohol which are economical and easy to obtain are used as raw materials, and the alkyl/alkenyl substituted nitrogen-containing heterocyclic compound is prepared under the synergistic promotion of alkali and additives; and methyl alkylation and alkenylation reaction are carried out to generate the corresponding alkyl/alkenyl substituted nitrogen-containing heterocyclic compound. The product has high application value and can be used in the fields of spices, medicines, materials, organic synthesis and the like. The method is wide in application range, simple in process, green, simple, high in yield and suitable for popularization and application.